Results 51 to 60 of about 72,976 (300)

Neuronal circuitry for pain processing in the dorsal horn [PDF]

, 2010
Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception.
A Dhaka, A Ribeiro-da-Silva, A Ribeiro-da-Silva, AF Keller, AG Brown, AH Watson, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AJ Todd, AL Bailey, AM Taylor, Andrew J. Todd, AR Light, AW Hantman, AW Hantman, B Lynn, B Rexed, BA Graham, C Albuquerque, C Gauriau, C Gauriau, C Gauriau, C Torsney, CJ Woodbury, CJ Woodbury, CJ Woolf, D Andrew, D Lima, D Lima, D Lima, D Lima, D Schoffnegger, D Schoffnegger, D Uta, DI Hughes, DI Hughes, DI Hughes, DJ Cavanaugh, DJ Maxwell, DL Bennett, DS Bredt, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, E Polgár, ET Zhang, ET Zhang, G Kato, GG Nagy, GJ Bennett, GJ Michael, GT Whiteside, H Baba, H Bester, H Ikeda, H Ikeda, H Sakamoto, HJ Hu, HY Huang, I Decosterd, I Laing, J Sandkuhler, J Scholz, J Zheng, JA Coull, JA Esteban, JF Bernard, JH Hwang, JJ Azkue, JL Hylden, JM Castro-Lopes, K Abe, K Feil, K Noguchi, KA Moore, KM Al-Khater, KM Al-Khater, KS Al Ghamdi, L Almarestani, L Sivilotti, LE Lorenzo, M Antal, M Antal, M Gassner, M Larsson, M Malcangio, M Mori, M Naim, M Okamoto, M Randic, M Rethelyi, M Zoli, MB Plenderleith, MJ Eaton, MJ Perry, MJ Zylka, ML Nichols, MM Heinricher, MM Naim, MW Salter, NK Littlewood, P Boscan, P Brumovsky, P Shortland, PD Wall, PW Mantyh, PW Mantyh, Q Liu, R Burstein, R Ruscheweyh, R Ruscheweyh, RC Spike, RC Spike, RM Slugg, RP Seal, RR Ji, S Neumann, S Neumann, SA Prescott, SA Shehab, SF Santos, SH Kim, SN Lawson, SP Schneider, T Ibuki, T Kemp, T Kohno, T Yasaka, T Yasaka, TJ Grudt, TL Yaksh, TP Malan, VS Seybold, WD Snider, WD Willis, X Zhang, X Zhang, XH Yu, Y Lu, Y Lu, Y Lu, YG Tong, YQ Ding, Z Puskár, ZS Han   +159 more
core   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Structural basis of neuropeptide Y signaling through Y1 and Y2 receptors

MedComm
Neuropeptide Y (NPY), a 36‐amino‐acid peptide, functions as a neurotransmitter in both the central and peripheral nervous systems by activating the NPY receptor subfamily.
Siyuan Shen, Yue Deng, Chenglong Shen, Haidi Chen, Lin Cheng, Chao Wu, Chang Zhao, Zhiqian Yang, Hanlin Hou, Kexin Wang, Zhenhua Shao, Cheng Deng, Feng Ye, Wei Yan   +13 more
doaj   +1 more source

Y₁ and Y₂ receptors for neuropeptide Y [PDF]

FEBS Letters, 1989
By using monoiodinated radioligands of both intact neuropeptide Y (NPY) and of a long C‐terminal fragment, NPY13–36, two subtypes of binding sites, which differ in affinity and specificity, have been characterized. The Y1 type of binding site, characterized on a human neuroblastoma cell line, MC‐IXC, and a rat pheochromocytoma cell line, PC‐12, binds ...
Sheikh, Søren P., Håkanson, Rolf, Schwartz, Thue W.   +2 more
openaire   +2 more sources

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Sympathetic nervous system catecholamines and neuropeptide Y neurotransmitters are upregulated in human NAFLD and modulate the fibrogenic function of hepatic stellate cells. [PDF]

PLoS ONE, 2013
Sympathetic nervous system (SNS) signalling regulates murine hepatic fibrogenesis through effects on hepatic stellate cells (HSC), and obesity-related hypertension with SNS activation accelerates progression of non-alcoholic fatty liver disease (NAFLD ...
Barbara Sigala, Chad McKee, Junpei Soeda, Valerio Pazienza, Maelle Morgan, Ching-I Lin, Clare Selden, Sara Vander Borght, Gianluigi Mazzoccoli, Tania Roskams, Manlio Vinciguerra, Jude A Oben   +11 more
doaj   +1 more source

The Lymnaea Cardioexcitatory Peptide (LyCEP) Receptor: A G-Protein–Coupled Receptor for a Novel Member of the RFamide Neuropeptide Family [PDF]

, 1998
A novel G-protein–coupled receptor (GRL106) resembling neuropeptide Y and tachykinin receptors was cloned from the molluscLymnaea stagnalis. Application of a peptide extract from the Lymnaea brain to Xenopus oocytes expressing GRL106 activated a calcium ...
Burke, Julian F, Cox, Kingsley J A, Geraerts, Wijnand P M, Hermann, Petra M, Knol, Jaco C, Meyerhof, Wolfgang, Planta, Rudi J, Richter, Dietmar, Smit, August B, Tensen, Cornelius P, van der Schors, Roel C, van Heerikhuizen, Harm, van Minnen, Jan, Vreugdenhil, Erno   +13 more
core   +7 more sources

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

A role of corazonin receptor in larval-pupal transition and pupariation in the oriental fruit fly Bactrocera dorsalis (Hendel) (Diptera: Tephritidae) [PDF]

, 2017
Corazonin (Crz) is a neuropeptide hormone, but also a neuropeptide modulator that is internally released within the CNS, and it has a widespread distribution in insects with diverse physiological functions.
Chen, Er-Hu, Gui, Shun-Hua, Hou, Qiu-Li, Jiang, Hong-Bo, Li, Hui-Min, Smagghe, Guy, Wang, Jin-Jun, Wei, Dan-Dan   +7 more
core   +2 more sources

Sulfakinin Signaling Sense Circulating Fructose and Suppresses Food Consumption via Insulin‐Like Peptide in Bactrocera Dorsalis

Advanced Science, EarlyView.
This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li, Bao Dong, Zheng‐Lin Ren, Xue‐Guang Zhu, Quan Lei, Yoonseong Park, Jin‐Jun Wang, Hong‐Bo Jiang   +7 more
wiley   +1 more source