Results 211 to 220 of about 75,376 (234)

Neuropeptide Y Receptor Subtypes, Y1 and Y2

Annals of the New York Academy of Sciences, 1990
Heterogeneity among NPY (and PYY) receptors was first proposed on the basis of studies on sympathetic neuroeffector junctions, where NPY (and PYY) can exert three types of action: 1) a direct (e.g., vasoconstrictor) response; 2) a postjunctional potentiating effect on NE-evoked vasoconstriction; and 3) a prejunctional suppression of stimulated NE ...
C, Wahlestedt, L, Grundemar, R, Håkanson, M, Heilig, G H, Shen, Z, Zukowska-Grojec, D J, Reis   +6 more
openaire   +2 more sources

Novel non-peptidic neuropeptide Y Y 2 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2004
Through SAR studies of a piperidinylindoline cinnamide HTS lead, the first potent, non-peptide, low molecular weight selective Neuropeptide Y Y2 (NPY Y2) antagonists have been synthesized. The SAR studies around the piperidinyl, the indolinyl, and the cinnamyl moieties are discussed.
Jill A, Jablonowski, Wenying, Chai, Xiaobing, Li, Dale A, Rudolph, William V, Murray, Mark A, Youngman, Scott L, Dax, Diane, Nepomuceno, Pascal, Bonaventure, Timothy W, Lovenberg, Nicholas I, Carruthers   +10 more
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Effect of a selective neuropeptide Y Y2 receptor antagonist, BIIE0246 on neuropeptide Y release

European Journal of Pharmacology, 2000
We have examined the selective neuropeptide Y Y(2) receptor antagonist, (S)-N(2)-[[1-[2-[4-[(R,S)-5,11-dihydro-6(6h)-oxodibenz[b, e]azepin-11-yl]-1-piperazinyl]-2-oxoethyl]cyclopentyl]acetyl ]-N-[2-[1 ,2-dihydro-3,5(4H)-dioxo-1,2-diphenyl-3-H-1,2, 4-triazol-4-yl]ethyl]-argininamid (BIIE0246) on neuropeptide release from rat hypothalamic slices in vitro.
P J, King, G, Williams, H, Doods, P S, Widdowson   +3 more
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Neuropeptide Y receptor antagonists.

IDrugs : the investigational drugs journal, 2005
A review of the patent literature for neuropeptide Y (NPY) antagonists is presented for the period of January 2000 to March 2001. This review focuses on antagonists of the Y(1) and Y(5) receptor subtypes, which have been of primary interest as anti-obesity agents.
openaire   +1 more source

Neuropeptide Y (NPY) Y1 Receptor Antagonists

2001
Neuropeptide Y(NPY), a 36-residue peptide amide isolated originally from porcine brain, exhibits a wide spectrum of central and peripheral activities mediated by at least six receptor subtypes denoted as Y1, Y2, Y3, Y4, Y5 and Y6 [1]. Investigations to date have implicated NPY in the pathophysiology of a number of diseases including feeding disorders ...
V. C. Dhawan, D. E. Mullins, W. T. Chance, S. Sheriff, M. Guzzi, E. M. Parker, A. Balasubramaniam   +6 more
openaire   +1 more source

Neuropeptide Y receptors in pig spleen

Acta Physiologica Scandinavica, 1987
A, Härfstrand, J M, Lundberg, K, Fuxe
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Neuropeptide Y receptors

Trends in Pharmacological Sciences, 1993
openaire   +1 more source

Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues

Progress in Neurobiology, 1992
Y, Dumont, J C, Martel, A, Fournier, S, St-Pierre, R, Quirion   +4 more
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Neuropeptide Y receptors

Trends in Pharmacological Sciences, 1997
openaire   +1 more source

Neuropeptide Y receptors

Trends in Pharmacological Sciences, 2001
openaire   +1 more source