Results 1 to 10 of about 50,047 (240)

In Vitro Biological Evaluation of Aprepitant Based ¹⁷⁷Lu-Radioconjugates

Pharmaceutics, 2022
Currently, the search for promising NK1R-positive tumor-targeting radiopharmaceuticals based on the structure of small molecular antagonists of neurokinin-1 receptor can be observed.
Paweł K. Halik, Przemysław Koźmiński, Joanna Matalińska, Piotr F. J. Lipiński, Aleksandra Misicka, Ewa Gniazdowska   +5 more
doaj   +1 more source

Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus

Molecules, 2020
In the present contribution, we analyze the influence that C-terminal extension of short opioid peptide sequences by organic fragments has on receptor affinity, in vivo analgesic activity, and antimelanoma properties.
Jolanta Dyniewicz, Piotr F. J. Lipiński, Piotr Kosson, Marta Bochyńska-Czyż, Joanna Matalińska, Aleksandra Misicka   +5 more
doaj   +1 more source

Neuropeptides [PDF]

WormBook, 2008
The role of neuropeptides in modulating behavior is slowly being elucidated. With the sequencing of the C. elegans genome, the extent of the neuropeptide genes in C. elegans can be determined. To date, 113 neuropeptide genes encoding over 250 distinct neuropeptides have been identified.
Chris, Li, Kyuhyung, Kim
openaire   +2 more sources

Can keratin scaffolds be used for creating three-dimensional cell cultures?

Open Medicine, 2020
Three-dimensional (3D) cell cultures were created with the use of fur keratin associated proteins (F-KAPs) as scaffolds. The procedure of preparation F-KAP involves combinations of chemical activation and enzymatic digestion.
Bochynska-Czyz Marta, Redkiewicz Patrycja, Kozlowska Hanna, Matalinska Joanna, Konop Marek, Kosson Piotr   +5 more
doaj   +1 more source

Neuropeptidomics: Mass Spectrometry-Based Identification and Quantitation of Neuropeptides [PDF]

Genomics & Informatics, 2016
Neuropeptides produced from prohormones by selective action of endopeptidases are vital signaling molecules, playing a critical role in a variety of physiological processes, such as addiction, depression, pain, and circadian rhythms.
Ji Eun Lee
doaj   +1 more source

Radiochemical Synthesis and Evaluation of Novel Radioconjugates of Neurokinin 1 Receptor Antagonist Aprepitant Dedicated for NK1R-Positive Tumors

Molecules, 2020
Aprepitant, a lipophilic and small molecular representative of neurokinin 1 receptor antagonists, is known for its anti-proliferative activity on numerous cancer cell lines that are sensitive to Substance P mitogen action.
Paweł K. Halik, Piotr F. J. Lipiński, Joanna Matalińska, Przemysław Koźmiński, Aleksandra Misicka, Ewa Gniazdowska   +5 more
doaj   +1 more source

LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism

Frontiers in Pharmacology, 2021
Apelin is a neuro-vasoactive peptide that plays a major role in the control of cardiovascular functions and water balance, but has an in-vivo half-life in the minute range, limiting its therapeutic use.
Adrien Flahault, Mathilde Keck, Pierre-Emmanuel Girault-Sotias, Lucie Esteoulle, Nadia De Mota, Dominique Bonnet, Catherine Llorens-Cortes   +6 more
doaj   +1 more source

Starfish smooth muscle relaxing activity of SALMFamide isotype peptide and its analog derived from starfish, Asterias rubens

Fisheries and Aquatic Sciences, 2022
An organism’s physiological processes and behaviors are regulated by neuropeptides and hormone peptides. The first neuropeptide identified from echinoderms is SALMFamide.
Anastasia Kubarova, Hye-Jin Go, Hye Young Oh, Nam Gyu Park   +3 more
doaj   +1 more source

Best Practices for Comprehensive Annotation of Neuropeptides of Gryllus bimaculatus

Insects, 2023
Genome annotation is critically important data that can support research. Draft genome annotations cover representative genes; however, they often do not include genes that are expressed only in limited tissues and stages, or genes with low expression ...
Takako Mochizuki, Mika Sakamoto, Yasuhiro Tanizawa, Hitomi Seike, Zhen Zhu, Yi Jun Zhou, Keisuke Fukumura, Shinji Nagata, Yasukazu Nakamura   +8 more
doaj   +1 more source

Neuropeptide W [PDF]

Frontiers in Endocrinology, 2012
Neuropeptide W (NPW), which was first isolated from the porcine hypothalamus, exists in two forms, consisting of 23 (NPW23) or 30 (NPW30) amino acids. These neuropeptides bind to one of two NPW receptors, either NPBWR1 (otherwise known as GPR7) or NPBWR2 (GPR8), which belong to the G protein-coupled receptor family.
Fumiko eTakenoya, Fumiko eTakenoya, Haruaki eKageyama, Haruaki eKageyama, Satoshi eHirako, Eiji eOta, Tetsuo eOgawa, Nobuhiro eWada, Tomoo eRyushi, Tomoo eRyushi, Seiji eShioda   +10 more
openaire   +3 more sources