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Annals of General Psychiatry, 2010 Neuropeptides comprise a diverse group of chemically distinct molecules, contained in and released from a range of sensory nerves. They are involved in the formation, transmission, modulation and perception of all types of pain (physiological, neuropathic and inflammatory). This fact is reflected on their wide distribution, from primary sensory neurons
Molyva Dimitra
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Insect Mating Behaviors: A Review of the Regulatory Role of Neuropeptides [PDF]
InsectsInsect mating behaviors are complex, diverse, and primarily regulated by neuropeptides and their receptors. Neuropeptides are peptide signaling molecules mainly secreted by insects’ central nervous system (CNS) to reach target organs.
Alfayo Ombuya, Jianyang Guo, Wanxue Liu
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The neuroscience of cancer: Focus on neuropeptidergic systems [PDF]
Acta Pharmaceutica Sinica BTumors are complex, highly heterogeneous diseases that place an enormous burden on the world's healthcare systems. Updating understanding of tumor initiation and progression is critical and the current breakthrough lies in cancer neuroscience, which ...
Zikai Dong, Yongfei Wang, Weilin Jin
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In Vitro Biological Evaluation of Aprepitant Based 177Lu-Radioconjugates
Pharmaceutics, 2022 Currently, the search for promising NK1R-positive tumor-targeting radiopharmaceuticals based on the structure of small molecular antagonists of neurokinin-1 receptor can be observed.
Paweł K. Halik +5 more
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Frontiers in Pharmacology, 2021 Apelin is a neuro-vasoactive peptide that plays a major role in the control of cardiovascular functions and water balance, but has an in-vivo half-life in the minute range, limiting its therapeutic use.
Adrien Flahault +6 more
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Molecules, 2020 In the present contribution, we analyze the influence that C-terminal extension of short opioid peptide sequences by organic fragments has on receptor affinity, in vivo analgesic activity, and antimelanoma properties.
Jolanta Dyniewicz +5 more
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Can keratin scaffolds be used for creating three-dimensional cell cultures?
Open Medicine, 2020 Three-dimensional (3D) cell cultures were created with the use of fur keratin associated proteins (F-KAPs) as scaffolds. The procedure of preparation F-KAP involves combinations of chemical activation and enzymatic digestion.
Bochynska-Czyz Marta +5 more
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WormBook, 2008 The role of neuropeptides in modulating behavior is slowly being elucidated. With the sequencing of the C. elegans genome, the extent of the neuropeptide genes in C. elegans can be determined. To date, 113 neuropeptide genes encoding over 250 distinct neuropeptides have been identified.
Chris, Li, Kyuhyung, Kim
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Neuropeptidomics: Mass Spectrometry-Based Identification and Quantitation of Neuropeptides [PDF]
Genomics & Informatics, 2016 Neuropeptides produced from prohormones by selective action of endopeptidases are vital signaling molecules, playing a critical role in a variety of physiological processes, such as addiction, depression, pain, and circadian rhythms.
Ji Eun Lee
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Molecules, 2020 Aprepitant, a lipophilic and small molecular representative of neurokinin 1 receptor antagonists, is known for its anti-proliferative activity on numerous cancer cell lines that are sensitive to Substance P mitogen action.
Paweł K. Halik +5 more
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