Results 151 to 160 of about 103,461 (277)

Critical role of the mast cell/tryptase/PAR2 axis in anastrozole‐induced pain

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anastrozole, an aromatase inhibitor, is used to treat postmenopausal women with hormone receptor‐positive breast cancer, but also induces musculoskeletal pain and can lead to therapeutic regimen suspension. Aromatase inhibitors promote the release of pro‐inflammatory substances from sensitised nerve fibres, which might ...
Maria Fernanda Pessano Fialho, Raquel Tonello, Evelyne Silva Brum, Gabriela Becker, Nigel W. Bunnett, Sara Marchesan Oliveira   +5 more
wiley   +1 more source

In silico structural and docking models of dipteran FXPRLamide neuropeptides support ligand-receptor coevolution and suggest mechanisms for ligand bias. [PDF]

PLoS One
Farris SM.
europepmc   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Role of Peptides in Skeletal Muscle Wasting: A Scoping Review. [PDF]

J Cachexia Sarcopenia Muscle
Naumovski P, De Spiegeleer B, Wakjira A, Van De Wiele C, Mouly V, Goljanek-Whysall K, da Costa KS, de Oliveira ECL, Wynendaele E, De Spiegeleer A.   +9 more
europepmc   +1 more source

Precision nutrition in weight loss and neuroendocrine control of people with obesity: The study protocol of a factorial randomised controlled trial (GenON Programme)

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Precision nutrition, guided by genetic testing, has emerged as a promising approach for managing obesity. However, robust clinical trials testing its effectiveness in real‐world dietary interventions remain scarce. The GenOn Programme aims to evaluate whether tailoring nutritional care based on genetic risk for obesity enhances weight ...
Karla P. Balbino, Ana Claudia P. Kravchychyn, Flávia G. Cândido, Mariana de Moura e Dias, Tiago Antônio de O. Mendes, Leandro Licursi de Oliveira, Luiza Carla V. Castro, Josefina Bressan, Ana Laura de la Garza, Fermín I. Milagro, María A. Zulet, Helen Hermana M. Hermsdorff   +11 more
wiley   +1 more source

Transcriptomics and Neuropeptidomics of the Cockroach <i>Rhyparobia maderae</i> to Characterize the Neuropeptide Landscape of the Cockroach's Circadian Clock. [PDF]

J Proteome Res
Neupert S, Shoaib SH, Schendzielorz J, Zolmon H, Hering L, Stengl M.   +5 more
europepmc   +1 more source

Diabetic kidney disease, biomarkers, and finerenone

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
wiley   +1 more source

Neuropeptides, Altruism, and Adverse Childhood Experiences: Investigating Biological and Behavioral Correlations in Medical Students. [PDF]

Brain Sci
Khong J, Bennett L, Felix Rivera J, Andrews N, Vuong V, Zapata D, Khong P, Ryznar R.   +7 more
europepmc   +1 more source

Gonadulin and Insulin‐Like Growth Factor Involved in Rhipicephalus microplus Reproduction

Entomologia Experimentalis et Applicata, EarlyView.
Insulin‐like growth factor (IGF2) in ovaries of Rhipicephalus microplus partially engorged females. Ovaries from females at different feeding stages were used to detect IGF2. ABSTRACT Gonadulin and insulin‐like growth factor (IGF) are neuropeptides synthesized by the central nervous system (CNS) of arthropods.
Jéssica Waldman, Lucas Teixeira de Castro, Vinícius Andrade‐Silva, Jéssica Andrade Paes, Luís Fernando Parizi, Maria Aparecida Juliano, Saulo Petinatti Pavarini, David Driemeier, Itabajara da Silva Vaz Jr.   +8 more
wiley   +1 more source