Results 171 to 180 of about 74,693 (295)

TRPM3 activation causes CGRP release in trigeminal neurons: Implications for migraine mechanisms

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Abstract Background The transient receptor potential melastatin 3 (TRPM3) ion channel has been implicated in sensory modulation and pain transmission and may contribute to migraine pathophysiology through calcitonin gene‐related peptide (CGRP) release in the trigeminovascular system. This study aimed to investigate TRPM3 activation and its role in CGRP
Philip V. Reducha   +9 more
wiley   +1 more source

Inhibitory effects of MK801 on activation of MAP kinase In adult rat hippocampus after Intracerebroventricular injections of glutamate, somatostatin and neuropeptide Y

open access: diamond, 1998
Kouji Fukushima   +6 more
openalex   +1 more source

Real‐world effectiveness and safety of galcanezumab for the treatment of migraine: A systematic review and meta‐analysis

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study aimed to summarize and pool real‐world evidence on the clinical effectiveness and safety of galcanezumab. Background Migraine is a disabling primary headache disorder. Several drugs that target calcitonin gene‐related peptide, such as galcanezumab, have recently been developed.
Jaime Fernández‐Bravo‐Rodrigo   +7 more
wiley   +1 more source

Toward high-efficiency, low-resource, and explainable neuropeptide prediction with MSKDNP. [PDF]

open access: yesBrief Bioinform
Xie P   +11 more
europepmc   +1 more source

A retrospective audit of the real‐world safety and effectiveness profile of eptinezumab for treatment‐resistant chronic migraine in Australia

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To describe the real‐world safety, tolerability, and effectiveness of eptinezumab for chronic migraine prevention in Australia. Background Eptinezumab is a relatively new medication for treatment‐resistant chronic migraine prevention.
Lakshini Gunasekera   +7 more
wiley   +1 more source

Amplifying and ameliorating light avoidance in mice with photoreceptor targeting and calcitonin gene‐related peptide sensitization

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective The aim of this study was to determine the photoreceptor basis of light avoidance in mice and assess the effect of CGRP sensitization on this behavior. Background Prior studies have suggested that photophobia is mediated by a subset of retinal ganglion cells (RGCs) that contain melanopsin, making them intrinsically photosensitive ...
Eric A. Kaiser   +3 more
wiley   +1 more source

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