Results 191 to 200 of about 17,164 (224)
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Structural and Functional Relation of Neuropilins
2002Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologues, Neuropilin-1 and -2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is divided into four domains, CUB (a1/a2) domain, FV/FVIII (b1/b2) domain, MAM (c) domain, and (d) domain that contains a transmembrane and a ...
Fumio, Nakamura, Yoshio, Goshima
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Neuropilin and Neuropilin Associated Molecules as New Molecular Targets in Pancreatic Adenocarcinoma
Anti-Cancer Agents in Medicinal Chemistry, 2011The Neuropilin receptors are increasingly recognized as receptors for vascular endothelial growth factors like VEGF-A and VEGF-C as well as other important growth factors like HGF and FGF in human vasculature and in tumor cells. More and more studies show an important role of Neuropilin in cancer biology suggesting that these transmembrane proteins ...
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Neuropilin-1 in the Immune System
2002The neuropilin-1 (NRP1) and neuropilin-2 (NRP2) receptors can bind the class 3 semaphorin subfamily and the heparin-binding forms of vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF). The functions of NRP1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they ...
Paul-Henri, Romeo +2 more
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Expression and mapping of duplicate neuropilin-1 and neuropilin-2 genes in developing zebrafish
Gene Expression Patterns, 2004Previously, we described the isolation and characterization of the first zebrafish neuropilin gene, which we now call nrp1a, and found its protein to be a mediator of vascular endothelial growth factor (VEGF)-dependent angiogenesis [Proc. Natl Acad. Sci. USA 99 (2002) 10470].
Diane E, Bovenkamp +8 more
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Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors
Nature Neuroscience, 1998Neuropilin-1 (NP-1) has been identified as a necessary component of a semaphorin D (SemD) receptor that repulses dorsal root ganglion (DRG) axons during development. SemA and SemE are related to SemD and bind to NP-1, but do not repulse DRG axons.
T, Takahashi +4 more
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Neuropilin 1 and Neuropilin 2: Cancer Progression and Biomarker Analysis
2017Neuropilins (NRP, human; Nrp, mouse) are a family of cell surface protein receptors originally named for their role in neuronal guidance during embryonic development. Over the past two decades, the expression, localization, regulation, and function of the NRP family have been intensely studied.
Xiaoran Li, Diane R. Bielenberg
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The Function of Neuropilin/L1 Complex
2002L1, a cell adhesion molecule of the Ig superfamily (IgCAM) plays a critical role in the formation of neuronal networks. This is reflected by the variety of clinical signs associated with the X-linked recessive neurological disorder that is caused by mutations in the L1 gene.
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The Function of Neuropilin/Plexin Complexes
2002Neuropilins bind the secreted class 3 semaphorins with high affinity but require a member of the plexin family to form receptors that are able to activate downstream signal transduction cascades. In this receptor complex neuropilins act as the ligand-binding subunit while plexins function as the signal-transducing subunit in the induction of ...
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Neuropilin invites reoviruses into neurons
Cell Host & MicrobeIn this issue of Cell Host & Microbe, Shang et al. identify murine neuropilin 1 as a host factor that binds reovirus particles, directing cell entry and contributing to viral dissemination and neurovirulence. This study highlights the reovirus model system to investigate host receptors and their significance in viral pathogenesis.
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