Results 71 to 80 of about 14,577 (176)
Lymphatic Endothelial Cells in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang +5 more
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2010 Background It is known that thiazolidinediones are involved in regulating the expression of various genes, including the vascular endothelial growth factor (VEGF) gene via peroxisome proliferator-activated receptor γ (PPARγ); VEGF is a prognostic ...
Yoshizaki Yumiko +6 more
doaj +1 more source
MedComm, Volume 7, Issue 8, August 2026.The study found that SARS‐CoV‐2 Omicron infection causes region‐specific inflammatory, immune, synaptic, and signaling disorders in the brain, and the predicted kinases and differentially expressed proteins may serve as potential targets for COVID‐19‐related drug discovery.
Qiaochu Wang +8 more
wiley +1 more source
A noncanonical role for Jagged1 in endothelial mechanotransduction
The FEBS Journal, Volume 293, Issue 15, Page 4604-4623, August 2026.The Notch signaling pathway plays a crucial role in regulating endothelial biology. Notch signaling is sensitive to hemodynamic forces and governs mechanically driven cardiovascular development, physiology, and remodeling. This study reveals a non‐canonical role for the Notch ligand Jagged1 in endothelial mechanotransduction.
Freddy Suarez Rodriguez +7 more
wiley +1 more source
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, Volume 293, Issue 16, Page 4789-4804, August 2026.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
Cancer Management and Research, 2019 Weifeng Pang,1 Mingcui Zhai,2 Yue Wang,3 Zhiqiang Li41Department of Internal Oncology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China; 2Department of Burn, Heilongjiang Province Hospital, Harbin ...
Pang W, Zhai M, Wang Y, Li Z
doaj
Frontiers in Oncology, 2019 Circulating proteins hold a potential benefit as biomarkers for precision medicine. Previously, we showed that systemic levels of neuropilin-1 (NRP-1) and its associated molecules correlated with poor-prognosis breast cancer. To further identify the role
Noura Al-Zeheimi +10 more
doaj +1 more source
Journal of Inflammation Research, 2020 Katarzyna Sznurkowska,1 Justyna Luty,2 Ewa Bryl,2 Jacek M Witkowski,3 Blanka Hermann-Okoniewska,4 Piotr Landowski,1 Marta Kosek,1 Agnieszka Szlagatys-Sidorkiewicz1 1Department of Pediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical ...
Sznurkowska K +7 more
doaj
Obstetrics and Gynecology International, 2009 While semaphorins and their receptors appear to play a role in tumor carcinogenesis, little is known about the role of semaphorin 3F (S3F) in epithelial ovarian cancer (EOC) development. Therefore, we sought to determine the clinical relationship between
Christina D. Drenberg +4 more
doaj +1 more source
Neuropilin-1 expression is associated with lymph node metastasis in breast cancer tissues
Cancer Management and Research, 2018 Mahnaz Seifi-Alan,1 Roshanak Shams,1 Mojgan Bandehpour,2 Reza Mirfakhraie,1 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Biotechnology, School of Advanced Technologies
Seifi-Alan M +4 more
doaj