Results 1 to 10 of about 113,556 (387)

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors

Science, 2023
Decreased dendritic spine density in the cortex is a hallmark of several neuropsychiatric diseases, and the ability to promote cortical neuron growth has been hypothesized to underlie the rapid and sustained therapeutic effects of psychedelics ...
Maxemiliano V. Vargas, Lee E. Dunlap, Chunyang Dong, Samuel J Carter, R. Tombari, Shekib A. Jami, Lindsay P. Cameron, Seona D. Patel, Joseph J. Hennessey, H. N. Saeger, J. McCorvy, J. A. Gray, L. Tian, D. E. Olson   +13 more
semanticscholar   +1 more source

Exploring the Role of Neuroplasticity in Development, Aging, and Neurodegeneration

Brain Science, 2023
Neuroplasticity refers to the ability of the brain to reorganize and modify its neural connections in response to environmental stimuli, experience, learning, injury, and disease processes.
P. Marzola, T. Melzer, E. Pavesi, J. Gil-Mohapel, P. Brocardo   +4 more
semanticscholar   +1 more source

Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications

Molecular Psychiatry, 2022
Major depressive disorder (MDD) was previously hypothesized to be a disease of monoamine deficiency in which low levels of monoamines in the synaptic cleft were believed to underlie depressive symptoms.
Alexandria N. Tartt, Madeline B Mariani, R. Hen, J. Mann, M. Boldrini   +4 more
semanticscholar   +1 more source

The nuclear lamina is a hub for the nuclear function of Jacob

Molecular Brain, 2021
Jacob is a synapto-nuclear messenger protein that couples NMDAR activity to CREB-dependent gene expression. In this study, we investigated the nuclear distribution of Jacob and report a prominent targeting to the nuclear envelope that requires NMDAR ...
Sebastian Samer, Rajeev Raman, Gregor Laube, Michael R. Kreutz, Anna Karpova   +4 more
doaj   +1 more source

Innovative Approaches and Therapies to Enhance Neuroplasticity and Promote Recovery in Patients With Neurological Disorders: A Narrative Review

Cureus, 2023
Brain rehabilitation and recovery for people with neurological disorders, such as stroke, traumatic brain injury (TBI), and neurodegenerative diseases, depend mainly on neuroplasticity, the brain's capacity to restructure and adapt.
J. Kumar, Tirath Patel, Fnu Sugandh, Jyotishna Dev, Umesh Kumar, Maham Adeeb, M. Kachhadia, P. Puri, Fnu Prachi, M. U. Zaman, Satesh Kumar, G. Varrassi, Abdul Rehman Shah Syed   +12 more
semanticscholar   +1 more source

Neddylation-dependent protein degradation is a nexus between synaptic insulin resistance, neuroinflammation and Alzheimer’s disease

Translational Neurodegeneration, 2022
Background The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Alzheimer's disease.
Alessandro Dario Confettura, Eleonora Cuboni, Mohamed Rafeet Ammar, Shaobo Jia, Guilherme M. Gomes, PingAn Yuanxiang, Rajeev Raman, Tingting Li, Katarzyna M. Grochowska, Robert Ahrends, Anna Karpova, Alexander Dityatev, Michael R. Kreutz   +12 more
doaj   +1 more source

Adaptive Neuroplasticity in Brain Injury Recovery: Strategies and Insights

Cureus, 2023
This review addresses the relationship between neuroplasticity and recovery from brain damage. Neuroplasticity's ability to adapt becomes crucial since brain injuries frequently result in severe impairments.
Vaishnavi Zotey, Amol Andhale, Tejas Shegekar, Anup Juganavar   +3 more
semanticscholar   +1 more source

Short high fat diet triggers reversible and region specific effects in DCX+ hippocampal immature neurons of adolescent male mice

Scientific Reports, 2021
Adolescence represents a crucial period for maturation of brain structures involved in cognition. Early in life unhealthy dietary patterns are associated with inferior cognitive outcomes at later ages; conversely, healthy diet is associated with better ...
Fausto Chiazza, Heather Bondi, Irene Masante, Federico Ugazio, Valeria Bortolotto, Pier Luigi Canonico, Mariagrazia Grilli   +6 more
doaj   +1 more source

Psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity

Chinese Medical Journal, 2023
Background: Posttraumatic stress disorder (PTSD) and depression are highly comorbid. Psilocybin exerts substantial therapeutic effects on depression by promoting neuroplasticity.
Yingjie Du, Yunfeng Li, Xiangting Zhao, Yishan Yao, Bin Wang, Liming Zhang, Guyan Wang   +6 more
semanticscholar   +1 more source

A Jacob/nsmf gene knockout does not protect against acute hypoxia- and NMDA-induced excitotoxic cell death

Molecular Brain, 2023
Jacob is a synapto-nuclear messenger protein that encodes and transduces the origin of synaptic and extrasynaptic NMDA receptor signals to the nucleus. The protein assembles a signalosome that differs in case of synaptic or extrasynaptic NMDAR activation.
Guilherme M. Gomes, Julia Bär, Anna Karpova, Michael R. Kreutz   +3 more
doaj   +1 more source