Chemical Biology &Drug Design, Volume 101, Issue 2, Page 340-349, February 2023., 2023 Non‐cytotoxic C2‐linked alkynyl oligo ethylene glycol adenosine conjugates are highly water soluble and stimulate adenosine receptor activity. Abstract A series of 12 novel polyethylene‐glycol(PEG)‐alkynyl C2‐adenosine(ADN) conjugates were synthesized using a robust Sonogashira coupling protocol and characterized by NMR spectroscopy and mass ...
Lindsay Ferguson +8 more
wiley +1 more source
Targeting C99 Mediated Metabolic Disruptions with Ketone Therapy in Alzheimer's Disease [PDF]
arXivThe role of ketone bodies in Alzheimers disease (AD) remains incompletely understood, particularly regarding their influence on amyloid pathology. While beta}hydroxybutyrate (BHB) has been implicated in neuroprotection, direct evidence for its effects on amyloid beta(Abeta) deposition, aggregation, or clearance is lacking. Furthermore, whether BHB acts
arxiv
Neuroprotection: role of the antiglaucomatous treatment [PDF]
, 1999 M Virno, Luigi Pannarale
openalex +1 more source
Journal of Translational MedicineTargeting drugs to the mitochondrial level shows great promise for acute and chronic treatment of traumatic brain injury (TBI) in both military and civilian sectors.
Jignesh D. Pandya +6 more
doaj +1 more source
Room F, 10/16/2000 9: 00 AM - 11: 00 AM (PS) Neuroprotection from Delayed Post-Ischemic Administration of a Metalloporphyrin Catalytic Antioxidant in the Rat [PDF]
, 2000 Georg B. Mackensen +4 more
openalex +1 more source
Targeting Connexin 43 in Retinal Astrocytes Promotes Neuronal Survival in Glaucomatous Injury
Glia, EarlyView.Astrocytes play an important role in glaucoma. These cells express Cx43, which can form gap junctions and hemichannels. This study shows that Cx43 deletion in astrocytes provides neuroprotection in glaucoma, possibly through hemichannel activation. ABSTRACT Astrocytes in the retina and optic nerve head play an important role in the pathogenesis of ...
Khulan Batsuuri +4 more
wiley +1 more source
The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations [PDF]
, 2000 Frank Striggow +5 more
openalex +1 more source
Neuroprotection mediated by changes in the endothelial actin cytoskeleton [PDF]
, 2000 Ulrich Laufs +14 more
openalex +1 more source
RNA-Protein Interaction Prediction Based on Deep Learning: A Comprehensive Survey [PDF]
arXivThe interaction between Ribonucleic Acids (RNAs) and proteins, also called RNA Protein Interaction (RPI), plays an important role in the life activities of organisms, including in various regulatory processes, such as gene splicing, gene localization, and disease pathogenesis.
arxiv
Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons [PDF]
, 2000 Kazuhiro Honda +6 more
openalex +1 more source