Results 121 to 130 of about 184,954 (326)

Oxygen sensors and energy sensors act synergistically to achieve a graded alteration in gene expression: consequences for assessing the level of neuroprotection in response to stressors [PDF]

, 2004
M.C. Renshaw Gillian
openalex   +1 more source

Disease Progression in Multiple System Atrophy: The ASPIRE Multi‐Modal Biomarker Study

Annals of Neurology, EarlyView.
Objective The objective of this study was to characterize changes in candidate biomarkers in early multiple system atrophy (MSA) and identify baseline predictors of faster progression. Methods This 1‐year, multicenter, prospective study assessed clinical, neuroimaging (3T‐magnetic resonance imaging [MRI], dopamine transporter single‐photon emission ...
Margherita Fabbri, Natalia del Campo, Wassilios G. Meissner, Vanessa Rousseau, Agnès Sommet, Pierre Payoux, Pierre Gantet, Amel Drif, Hélène Catalá, Claire Thalamas, Christine Tranchant, Franck Durif, Ana Marques, Alexandre Eusebio, Luc Defebvre, Jean‐Christophe Corvol, Stéphane Thobois, Anthime Flaus, Anne‐Gaelle Corbille, Solène Frismand, Beverley Patterson, Alexandra Foubert‐Samier, Anne Pavy‐Le Traon, Germain Arribarat, Patrice Péran, Olivier Rascol, for the ASPIRE Study Group   +26 more
wiley   +1 more source

Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system

Communications Biology
Crosstalk between central nervous system (CNS) and systemic responses is important in many pathological conditions, including stroke, neurodegeneration, schizophrenia, epilepsy, etc.
Ester Licastro, Giuseppe Pignataro, Jeffrey J. Iliff, Yanxiao Xiang, Eng H. Lo, Kazuhide Hayakawa, Elga Esposito   +6 more
doaj   +1 more source

Poly-arginine peptide R18D reduces neuroinflammation and functional deficits following traumatic brain injury in the Long-Evans rat [PDF]

, 2019
We have previously demonstrated that the poly-arginine peptide R18 can improve histological and functional outcomes following traumatic brain injury (TBI) in the Sprague–Dawley rat.
Anderton, Ryan S, Chiu, Li Shan, Clark, Vince W, Cross, Jane L, Knuckey, Neville W, Meloni, Bruno P   +5 more
core   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

Effects of senescence on astrocyte to brain endothelial cell signaling

Neuroprotection
Background Aging affects almost all aspects of central nervous system (CNS) function, including the blood–brain barrier (BBB). Here, we use cell culture models to ask whether senescence, a cellular feature of aging, alters the BBB by modifying ...
Shuzhen Guo, Gen Hamanaka, Fang Zhang, Janice Lee, Ji Hyun Park, Wenlu Li, Ken Arai, Eng H. Lo   +7 more
doaj   +1 more source

Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6

Annals of Neurology, EarlyView.
Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang, Taylor L. Charron, Min Fu, Miranda Dunn, Deborah M. Jones, Praveen Kumar, Satoshi Ishishita, Allan‐Hermann Pool, Ashwinikumar Kulkarni, Genevieve Konopka, Vikram G. Shakkottai   +10 more
wiley   +1 more source

Prospective, Multicenter Evaluation of Transcarotid Artery Revascularization in Standard‐Risk Patients: 30‐Day Outcomes of the ROADSTER 3 Study

Annals of Neurology, EarlyView.
Objective To evaluate the real‐world safety and efficacy for standard surgical risk patients with extracranial internal carotid artery disease undergoing transcarotid artery revascularization. Methods ROADSTER 3 is a prospective, multicenter, single‐arm post‐approval study.
Jeffrey Jim, Meghan Dermody, Brian Peterson, Scott S. Berman, Nicolas J. Mouawad, Joseph Ricotta, Naveed Saqib, Peter Faries, Angela Martin, Joshua D. Adams, Uttam Tripathy, Daniel Calderon, David O'Connor, Rasesh Shah, Sumaira Macdonald, Marc L. Schermerhorn   +15 more
wiley   +1 more source

Exercise-Induced Neuroprotection and Recovery of Motor Function in Animal Models of Parkinson's Disease [PDF]

, 2019
Ewelina Pałasz, Wiktor Niewiadomski, Anna Gąsiorowska, Adrianna Wysocka, Anna Stępniewska, Grażyna Niewiadomska   +5 more
openalex   +1 more source

Brain-derived CCR5 Contributes to Neuroprotection and Brain Repair after Experimental Stroke

, 2021
Suning Ping, Xuecheng Qiu, Michele Kyle, Li‐Ru Zhao   +3 more
openalex   +1 more source