Results 201 to 210 of about 20,490 (222)

Selective Estrogen Receptor Modulator LY353381.HCl-Mediated Neuroprotection and BCL-2 Expression After Experimental Stroke [PDF]

, 2001
Mark I. Rossberg, Nabil J. Alkayed, Hung D Joh, Stephanie J. Murphy, Richard J Trastman, Patricia D. Hurn   +5 more
openalex   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

A review of the putative antiseizure and antiepileptogenic mechanisms of action for soticlestat

Epilepsia, EarlyView.
Abstract Soticlestat (TAK‐935) is a potent and selective inhibitor of cholesterol 24‐hydroxylase (CYP46A1), an enzyme primarily expressed in the brain that catabolizes cholesterol to 24S‐hydroxycholesterol (24HC). In the ELEKTRA phase II clinical trial, soticlestat reduced seizure frequency in patients with developmental and epileptic encephalopathies,
Shinichi Kondo, Venkatesha Murthy, Mahnaz Asgharnejad, Arturo Benitez, Kosuke Nakashima, Nicole Hawkins, H. Steve White   +6 more
wiley   +1 more source

Voluntary running wheel activity reduces seizure burden and affords neuroprotection in a mouse model of acquired epilepsy

Epilepsia, EarlyView.
Abstract Objective Physical exercise may improve neurological deficits and neuronal damage after acute brain injuries and decrease established seizures. We investigated whether voluntary running wheel (RW) activity affects epileptogenesis in a mouse model of acquired epilepsy compared to sedentary mice.
Valentina Kebede, Rossella Di Sapia, Nicole Tonesi, Massimo Rizzi, Silvia Balosso, Daniele Spallaci, Ilaria Craparotta, Laura Pasetto, Valentina Bonetto, Gerardo Marsella, Luca Porcu, Giorgio Rosati, Alessandro Ieraci, Annamaria Vezzani   +13 more
wiley   +1 more source

Blocking the innate immune CD1d/NKT cell axis prevents the development of cortical hyperexcitability and posttraumatic epilepsy

Epilepsia, EarlyView.
Abstract Objective Posttraumatic epilepsy (PTE) that develops after a traumatic brain injury (TBI) cannot be prevented by current treatments. Although neuroinflammation is involved in epileptogenesis, a potential role for cellular immunity in this process is largely unknown.
Xingjie Ping, Wenhui Xiong, Raj Priya, Jianyun Liu, Season K. Wyatt‐Johnson, Randy R. Brutkiewicz, Xiaoming Jin   +6 more
wiley   +1 more source

Immunity and neuroinflammation in early stages of life and epilepsy

Epilepsia, EarlyView.
Abstract The immune system is crucial for the correct brain development, and recent findings also point toward central control of immune response. As the immune system is not fully developed at birth, the early years become an important window for infections and for the development of epilepsy.
Angelica Vega García, María Leonor López‐Meraz, Marco I. González, Luisa Rocha, Jose Eduardo Peixoto‐Santos, Esper Abrão Cavalheiro   +5 more
wiley   +1 more source

Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response

The FEBS Journal, EarlyView.
A targeted mass spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy. We demonstrated a broad shift in the circulating stress‐relevant plasma metabolome associated with stressful scruff handling that was ...
Erynn E. Johnson, James M. Ervasti
wiley   +1 more source

A non‐redundant role of EAAT3 for ATP synthesis mediated by GDH in dopaminergic neuronal cells: a new avenue for glutamate metabolism and protection in Parkinson's disease

The FEBS Journal, EarlyView.
Parkinson's disease (PD) is a severe brain disorder caused by the loss of dopaminergic neurons. This study found that activating the enzyme glutamate dehydrogenase (GDH), by using the GDH activator BCH, protects cells and improves their energy production. It also highlights the previously undescribed role of EAAT3 in GDH‐dependent protection against PD
Alessandra Preziuso, Tiziano Serfilippi, Marwa Toujani, Valentina Terenzi, Salvatore Amoroso, Simona Magi, Vincenzo Lariccia, Silvia Piccirillo   +7 more
wiley   +1 more source

Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44

The FEBS Journal, EarlyView.
Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser, Milena Lubisch, Emma Schröder, Luka Ressmann, Marie Nicolaus, Dustin Leusder, Sven Moyzio, Robert Peuss, Antonio Miranda‐Vizuete, Eva Liebau   +9 more
wiley   +1 more source

Reversing Microglial Polarisation by High Intensity Interval Training: A Novel Approach to Mitigate Inflammatory Responses in Osteoarthritis via Jak2/Stat3 Pathway

Immunology, EarlyView.
This study demonstrates that high‐intensity interval training (HIIT) effectively alleviates OA‐induced inflammation by promoting M1 to M2 microglial polarisation via the Jak2/Stat3 pathway. HIIT increases pain thresholds and down‐regulates the expression of pro‐inflammatory factors such as Tmem119, SP, Glu, c‐Fos, and IL‐6 in an OA rat model.
Xinwei Wang, Mingxia Gao, Peng Xia, Ziqi Ye, Fanghui Li, Xueping Li   +5 more
wiley   +1 more source