Results 101 to 110 of about 339,661 (301)

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain [PDF]

, 2012
Background: Cytokines such as interleukin 6 (IL-6) have been implicated in dual functions in neuropsychiatric disorders. Little is known about the genetic predisposition to neurodegenerative and neuroproliferative properties of cytokine genes.
A Kitamura, AA Willette, AH Miller, AL Jefferson, AL Marsland, AL Sousa, American Psychiatric Association, Astrid V Rauch, AT Beck, B Balasubramaniam, B Viviani, Bernhard T Baune, BL Pierce, BT Baune, BT Baune, Carsten Konrad, CF Terry, Christina Uhlmann, CS Carlson, Dominik Grotegerd, E Brietzke, E Halperin, E Vermetten, Eva Birosova, F Faul, GM MacQueen, H Tilg, H-U Wittchen, Harald Kugel, I HapMap, I Hickie, I Morales, J Ashburner, J Hannestad, J McAfoose, J Oh, JA Wagner, JE Malberg, JM Gatt, JM Kim, Jochen Bauer, JP Godbout, K Kasai, K Pham, Katharina Domschke, KK Bowen, L Capuron, L Christiansen, L Vallieres, L Vitkovic, LD Ward, M Bonafe, M Murphy, M Pickering, M Yamada, MA Kahn, MA Munoz-Fernandez, MK Kang, ML Monje, MT Heneka, N Ohbayashi, N Pervaiz, N Raz, N Tzourio-Mazoyer, O Davidovich, O Islam, P Angelopoulos, P Oeth, P Videbech, Patricia Ohrmann, RA Gadient, RA Gadient, RM Thomas, S Campbell, S Eickhoff, S Ihara, S Ihara, S Lehrl, S Matsuda, S Toulmond, SA Loddick, SD Forman, Sonja Schöning, T Beblo, T Frodl, T Hama, T Hama, T Hirano, Thomas Suslow, U Dannlowski, Udo Dannlowski, V Tancredi, Volker Arolt, Walter Heindel, Y Akaneya, Y Dowlati, Y Kushima, Y Kushima, YP Peng, YY Wu   +99 more
core   +3 more sources

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Focusing on mitochondria in the brain: from biology to therapeutics

Translational Neurodegeneration
Mitochondria have multiple functions such as supplying energy, regulating the redox status, and producing proteins encoded by an independent genome. They are closely related to the physiology and pathology of many organs and tissues, among which the ...
Nanshan Song, Shuyuan Mei, Xiangxu Wang, Gang Hu, Ming Lu   +4 more
doaj   +1 more source

NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy [PDF]

, 2013
Alzheimer’s disease (AD) is a devastating neurodegenerative disease causing irreversible cognitive decline in the elderly. There is no disease-modifying therapy for this condition and the mechanisms underpinning neuronal dysfunction and neurodegeneration
Cowan, C.M., Mudher, A., Quraishe, S.
core   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson\u27s Disease. [PDF]

, 2019
While GM1 may interact with α-synuclein in vitro to inhibit aggregation, the ability of GM1 to protect against α-synuclein toxicity in vivo has not been investigated.
Aras, Radha, Brotchie, Jonathan M., Koprich, James B., Schneider, Jay S., Singh, Vikrant, Williams, Courtney K.   +5 more
core   +1 more source

Systemic infections after acute stroke [PDF]

, 2008
After an acute stroke, systemic infection can complicate the recovery process and lead to a worse clinical outcome, including a higher risk of mortality.
Damian Jenkinson, Englyst, Hamidon, Joseph Kwan, Kammersgaard, Kwan, Mike Vassallo, Nicola Englyst, Niel-Weise, Oconnor, V Hugh Perry, Werner   +11 more
core   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Neuroprotective impact of Ximenia americana aqueous bark extract on Diazepam-induced memory impairment in mice via its antioxidant potential

Notulae Scientia Biologicae
In traditional medicine, Ximenia americana (XA) is used to treat mental disorders, and headaches. The current study aimed to show the preventive and biochemical impacts of XA aqueou’s extract on diazepam-induced amnesia. Mice were randomized as follows:
Galba J. BEPPE, Roland Nhouma REBE, Man-Ikré MAÏTEMWA, Alice I. FOLEFACK, Bertrand P. BARGA, Nanou G. ALLAH-DOUM, Alain B. DONGMO   +6 more
doaj   +1 more source