Results 111 to 120 of about 339,661 (301)

Potential Neuroprotective Treatment of Stroke: Targeting Excitotoxicity, Oxidative Stress, and Inflammation

Frontiers in Neuroscience, 2019
Stroke is a major cause of death and adult disability. However, therapeutic options remain limited. Numerous pathways underlie acute responses of brain tissue to stroke.
Qianwen Yang, Qianyi Huang, Zhiping Hu, Xiangqi Tang   +3 more
doaj   +1 more source

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments

Advanced Healthcare Materials, EarlyView.
Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise, Fucen Luo, Borislav Angelov, Yuru Deng, Angelina Angelova   +4 more
wiley   +1 more source

Metformin and Cognitive Performance in Patients With Type 2 Diabetes: An Umbrella Review

Neuropsychopharmacology Reports
Contradictory results for the association between metformin intake and changes in cognitive function have been reported. We attempted to overview systematic reviews and meta‐analyses showing the role of metformin, as mono or combination therapy, in ...
Athena Enderami, Behnam Shariati, Mehran Zarghami, Aily Aliasgharian, Mobin Ghazaiean, Hadi Darvishi‐Khezri   +5 more
doaj   +1 more source

Chronic cocaine enhances release of neuroprotective amino acid taurine: a microdialysis study [PDF]

, 2008
Cocaine inhibits high-affinity neurotransmitter uptake at the presynaptic nerve terminals to increase synaptic levels of dopamine, norepinephrine and serotonin^1^. This increase of synaptic dopamine may cause neurotoxicity^2,3^.
Eitan Freedman, Elena Yablonski-Alter, Eleonora Gashi, Mervan Agovic, Shailesh Banerjee, Theodore Lidsky   +5 more
core   +1 more source

Technical aspects of an impact acceleration traumatic brain injury rat model with potential suitability for both microdialysis and PtiO2 monitoring

, 2007
This report describes technical adaptations of a traumatic brain injury (TBI) model-largely inspired by Marmarou-in order to monitor microdialysis data and PtiO2 (brain tissue oxygen) before, during and after injury. We particularly focalize on our model
Bruno Palmier, Bullock, Emilie Carré, Emmanuel Cantais, Foda, Gentleman, Jean-Jacques Risso, Jean-Pierre Terrier, Kawaguchi, Marmarou, Michel Lonjon, Olivier Darbin, Paxinos, Piper, Povlishock, Schallert, Warner   +16 more
core   +1 more source

Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: a systematic review [PDF]

, 2009
Background Granulocyte-colony stimulating factor (G-CSF) shows promise as a treatment for stroke. This systematic review assesses G-CSF in experimental ischaemic stroke.
Alvarez-Dolado, Bath, Bath, Claire L. Gibson, Crain, Crossley, del Zoppo, Egger, England, Fisher, Gibson, Gibson, Gibson, Han, Hasselblatt, Hermann, Jendelova, Kawada, Kollmar, Komine-Kobayashi, Lan, Lee, Lees, Macleod, Matchett, Minnerup, Nagata, Philip M.W. Bath, Schabitz, Schneider, Schneider, Sehara, Sehara, Sena, Sevimli, Shuaib, Shyu, Shyu, Shyu, Six, Solaroglu, Solaroglu, Sprigg, Sprigg, Sykova, Taguchi, Timothy J. England, Toth, Vellenga, Wardlaw, Willmot, Yanqing, Zhao, Zhao, Zsebo, Zucali   +55 more
core   +2 more sources

Non‐Invasive Brain Targeted Delivery of Cannabidiol for Alleviating Neuroinflammatory Disease

Advanced Materials, EarlyView.
The glucose‐functionalized nanoparticles (GNPs) are developed for the brain‐targeted delivery of cannabidiol (CBD). GNPs bypass the blood‐brain barrier (BBB) via glucose transporter‐1 (GLUT‐1) and release CBD in response to reactive oxygen species (ROS).
Yibin Wang, Yundong Li, Xin Wang, Yaning Hou, Wei Deng, Meng Zheng, Yan Zou, Bingyang Shi   +7 more
wiley   +1 more source

Functional equivalence of stem cell and stem cell-derived extracellular vesicle transplantation to repair the irradiated brain. [PDF]

, 2020
Cranial radiotherapy, although beneficial for the treatment of brain tumors, inevitably leads to normal tissue damage that can induce unintended neurocognitive complications that are progressive and debilitating. Ionizing radiation exposure has also been
Acharya, Munjal M, Angulo, Maria C, Baulch, Janet E, Chmielewski, Nicole N, Giedzinski, Erich, Liang, Yaxuan, Limoli, Charles L, Lu, Celine, Lui, Tiffany, Martirosian, Vahan, Park, Audrey L, Ru, Ning, Smith, Sarah M, Tang, Sharon   +13 more
core  

The relevance of α-KLOTHO to the central nervous system: Some key questions [PDF]

, 2017
α-Klotho is well described as an anti-aging protein, with critical roles in kidney function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum.
Berwick, Daniel Charles, Cararo-Lopes, Marina Minto, Kawamoto, Elisa Mitiko, Mazucanti, Caio Henrique Yokoyama, Scavone, Cristoforo   +4 more
core   +1 more source

IL‐3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury

Advanced Science, EarlyView.
IL‐3 recruits PRDX1 through IL‐3R to modulate the inflammatory response of microglia via the KEAP1‐NRF2‐HO‐1/NF‐κB pathway to attenuate neuroinflammation in traumatic brain injury. ABSTRACT Microglia play a crucial role in the progression of neuroinflammation following traumatic brain injury (TBI). Interleukin‐3 (IL‐3), a significant regulatory factor,
Nana Huang, Qingchen Zhang, Yanrui Chen, Dapeng Yu, Ronghan Liu, Jianning Kang, Xiang Fang, Ying Zhang, Hong Bian, Yanxin Zhao, Yongcheng Yin, Ce Zhang, Yanfei Jia, Qingfa Chen, Yuepeng Fang, Shang Li, Fang Li, Zhengxin Jin, Bin Ning   +18 more
wiley   +1 more source