Results 161 to 170 of about 218,532 (303)

The small molecule simufilam dose‐dependently attenuates the worsening of seizures in a mouse model of tuberous sclerosis complex

Epilepsia, EarlyView.
Abstract Objective Novel epilepsy treatments for patients with tuberous sclerosis complex (TSC) and focal cortical dysplasia type II (FCDII) are urgently needed. In these patients, mutations in the mechanistic target of rapamycin (mTOR) pathway genes lead to mTOR hyperactivity and focal cortical malformations that frequently cause intractable epilepsy ...
Branden Stansley, Md. Monirul Islam, Dean J. Aguiar, Zoë Fuchs, Mackenzie Catron, Stephen Morairty, Ying Yuan, Radleigh Santos, Jingguo Hou, Annelies de Kater, George B. Thornton, Angelique Bordey   +11 more
wiley   +1 more source

White Matter Hyperintensities and Neuropsychiatric Symptoms in Neurodegenerative Diseases. [PDF]

J Clin Neurol
Katakami S, Kanemoto H, Taomoto D, Satake Y, Suehiro T, Sato S, Yoshiyama K, Kashibayashi T, Takahashi R, Tagai K, Shinagawa S, Ishii K, Kazui H, Ikeda M.   +13 more
europepmc   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Neuropsychiatric Symptoms at Menopause

The Journal of South Asian Federation of Menopause Societies, 2015
PK Maheshwari, Prabhat Agrawal, Prashant Prakash, Anjana Pandey   +3 more
openaire   +1 more source

Real‐world effectiveness of highly purified cannabidiol in epilepsy associated with 15q11.2‐q13.1 duplication and deletion syndromes: A multicenter study

Epilepsia Open, EarlyView.
Abstract This multicenter retrospective study evaluated the effectiveness and safety of highly purified cannabidiol (CBD) in 22 patients with 15q11.2‐q13.1 duplication or deletion syndromes (15q‐DDS), including 12 with 15q duplication syndrome (dup15q) and 10 with Angelman syndrome (AS). Median (interquartile range [IQR]) age at CBD initiation was 14.5
Emanuele Cerulli Irelli, Adolfo Mazzeo, Marco Perulli, Georgia Ramantani, Domenica Battaglia, Irene Bagnasco, Erica Cognolato, Pasquale Striano, Susanna Negrin, Alberto Danieli, Paolo Bonanni, Francesca F. Operto, Carlo Di Bonaventura, Antonietta Coppola, Alessandro Orsini   +14 more
wiley   +1 more source

Trajectories of quality of life, anxiety and depressive symptomatology, and health‐related work productivity after first seizure events

Epilepsia Open, EarlyView.
Abstract Objective First seizure events are common and may exert an immediate and profound impact on people's lives. Less understood are their long‐term consequences. This prospective, longitudinal study aimed to measure and compare psychosocial and health‐related work productivity trajectories following first seizure events of various etiologies ...
Emma Foster, Zhibin Chen, Alison Conquest, David N. Vaughan, Chris Tailby, Patrick W. Carney, Wendyl D’Souza, Hue Mun Au Yong, John‐Paul Nicolo, Jacob Pellinen, Danny Liew, Terence J. O’Brien, Patrick Kwan, Zanfina Ademi   +13 more
wiley   +1 more source

Neuropsychiatric symptoms in sporadic Creutzfeldt-Jakob disease. [PDF]

Brain
Zitser J, Forner S, Wong K, Chengshi J, Neuhaus J, Martindale J, Raudabaugh BJ, Benisano K, Goodman-O'Leary K, Metcalf S, Kim MO, Hakimi M, Allen IE, Miller BL, Rosen HJ, Rankin KP, Geschwind MD.   +16 more
europepmc   +1 more source

Global disparities in the recognition, diagnosis, and management of seizures or epilepsy of autoimmune etiology

Epilepsia Open, EarlyView.
Abstract Objective Despite advancements in “autoimmune epilepsy,” more accurately referred to herein as seizures or epilepsy of autoimmune etiology, significant variability exists in its recognition, diagnosis, and management internationally. This study assessed clinicians' understanding, access to diagnostic tools, and treatment practices across ...
Emily Guarasci, Robyn Whitney, Adrian Budhram, Maryam Nabavi Nouri   +3 more
wiley   +1 more source

The role of the endocannabinoid system in managing neuropsychiatric symptoms in Alzheimer's disease. [PDF]

Front Psychiatry
Rao JS, Alejandra Tangarife M, Venegas MM, Forero B, González Tamayo LL, Escobar-Gallego JP, Rodríguez-Soacha DA, Ferreiros A, Mukunda R.   +8 more
europepmc   +1 more source