Results 181 to 190 of about 218,532 (303)

White Matter Dysfunction and Neurotransmitter Basis Underlying the Freezing of Gait in Parkinson's Disease

iNew Medicine, EarlyView.
In the freezing of gait in Parkinson's disease, white matter shows decreased local activity but increased functional connectivity. These distinct dysfunctions are uniquely associated with specific neurotransmitter systems (GABA, dopamine, etc.), mapping a new neurochemical basis for this debilitating symptom. ABSTRACT Freezing of gait (FOG) is a severe
Pingping Liu, Jinmei Sun, Lili Hu, Xin Chen, Jinying Han, Liuzhenxiong Yu, Siyu Fan, Rong Ye, Kai Wang, Gong‐Jun Ji, Panpan Hu   +10 more
wiley   +1 more source

Cognitive and behavioural predictors of survival in Alzheimer disease:results from a sample of treated patients in a tertiary-referral memory clinic [PDF]

, 2012
Agüero-Torres, Andersen, Brandt, Brookmeyer, Buchner, Cox, Cummings, Doody, Ferri, Folstein, Gambassi, General Register Office for Scotland, Helmer, Hicks, Hötte, Inouye, ISD Scotland, Kaplan, Knopman, Landi, Larson, Lawton, Lezak, Luchsinger, Martyn, McGurn, McKhann, Mental Welfare Commission for Scotland, Mielke, Miller, Morgan, Musicco, Nelson, Newcomer, Rait, Reisberg, Richards, Robbins, Scarmeas, Scarmeas, Schneider, Sinforiani, Solfrizzi, SPSS Inc, Starr, Starr, Starr, Starr, Stern, Stern, Stern, Stern, Thomas, Tsai, Tun, Van Dijk, Wang, Whalley, Whitmer, Wolfson   +59 more
core   +1 more source

Disrupted Brain Structure and Function in Alzheimer's Disease Patients With Behavioral and Psychological Symptoms

iNew Medicine, EarlyView.
ABSTRACT Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in Alzheimer's disease (AD), but the underlying mechanisms are unclear. This study aims to elucidate the neuropathological mechanisms underlying BPSD by investigating gray matter volume (GMV) and brain connectivity in AD patients with and without BPSD.
Xuerui Pang, Linbo Xie, Mengdan Chen, Yi Ji, Yibing Yan, Shanshan Zhou, Panpan Hu, Xingqi Wu, Kai Wang   +8 more
wiley   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib. [PDF]

Ann Clin Transl Neurol
Jones A, Bonomi S, Stockerl-Goldstein KE, Bateman RJ.   +3 more
europepmc   +1 more source

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source

Fatigue and neuropsychiatric symptoms in Parkinson's disease: a narrative review. [PDF]

Front Neurol
Bojtos L, Rodríguez-Antigüedad J, Pagonabarraga J, Martínez-Horta S, Kulisevsky J.   +4 more
europepmc   +1 more source

The We‐Relationship as a Key to Addressing Dementia‐Related Ambiguous Loss

Journal of Applied Philosophy, EarlyView.
ABSTRACT Pauline Boss describes the challenges faced by people caring for family members with dementia in terms of ambiguous loss – a condition in which the physical presence of the person with dementia coexists with their psychological absence. This article proposes the concept of we‐relationship as a key to addressing dementia‐related ambiguous loss.
Takuya Niikawa, Xue Li
wiley   +1 more source

Neuropsychiatric symptoms in preclinical and clinically manifest dementia: clusters and their health determinants. [PDF]

Alzheimers Dement
Guazzarini AG, Galaris E, Boccardi V, Mancinetti F, Ruggiero C, Muehlboeck JS, Mecocci P, Westman E, Marseglia A.   +8 more
europepmc   +1 more source

Neurodevelopmental variations cascading from age 10 months to 3 years leading to attention‐deficit hyperactivity disorder/autism traits at age 9 in a general population

JCPP Advances, EarlyView.
Associations of neurodevelopmental measures (Z‐scores of gross motor, visual reception, fine motor, receptive language, expressive language) at ages 10, 14, 18, 24, 32, and 40 months with (a) attention‐deficit/hyperactivity disorder trait, (b) autism spectrum disorder trait, (c) developmental coordination disorder trait, and (d) intellectual ...
Kenji J. Tsuchiya, Nagahide Takahashi, Yoko Nomura, Jeffrey H. Newcorn, Shigenobu Toda, Yuuka Ishikawa‐Omori, Akemi Okumura, Mohammad Shafiur Rahman, Toshiki Iwabuchi, Taeko Harada, Ikue Hirata, Chikako Nakayasu, Yuko Amma, Haruka Suzuki, Tomoko Nishimura   +14 more
wiley   +1 more source