Results 201 to 210 of about 1,522,567 (255)

The emergence of neuropsychiatric symptoms in preclinical Alzheimer's disease: An emotion regulation perspective. [PDF]

Neuron
Turnbull A, Gross JJ, Vankee-Lin F.
europepmc   +1 more source

The womb as the cradle of longevity: Perinatal origins of biological aging

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract The perinatal period is increasingly recognized as an important determinant of biological aging trajectories and disease susceptibility across the lifespan. This narrative review synthesizes current evidence linking intrauterine exposures to adult health outcomes across three biological dimensions: fetal programming, maternal influences, and ...
Sevim Ozge Ozdemir, Ebru Davutoglu
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Neuropsychiatric symptoms in sporadic Creutzfeldt-Jakob disease. [PDF]

Brain
Zitser J, Forner S, Wong K, Chengshi J, Neuhaus J, Martindale J, Raudabaugh BJ, Benisano K, Goodman-O'Leary K, Metcalf S, Kim MO, Hakimi M, Allen IE, Miller BL, Rosen HJ, Rankin KP, Geschwind MD.   +16 more
europepmc   +1 more source

Disrupted Brain Structure and Function in Alzheimer's Disease Patients With Behavioral and Psychological Symptoms

iNew Medicine, EarlyView.
ABSTRACT Objective Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in Alzheimer’s disease (AD), but the underlying mechanisms are unclear. This study aims to elucidate the neuropathological mechanisms underlying BPSD by investigating gray matter volume (GMV) and brain connectivity in AD patients with and without BPSD ...
Xuerui Pang, Linbo Xie, Mengdan Chen, Yi Ji, Yibing Yan, Shanshan Zhou, Panpan Hu, Xingqi Wu, Kai Wang   +8 more
wiley   +1 more source

Seronegative Autoimmune Encephalitis Presenting With Severe Neuropsychiatric Symptoms in an Older Adult: A Case of Diagnostic Complexity. [PDF]

Case Rep Psychiatry
Potts CE, Ali A, Issa J, Alizai U, May D.   +4 more
europepmc   +1 more source

Bidirectional Pathological Axis Between Alzheimer's Disease and Circadian Rhythm Disturbance: Mechanisms and Therapeutic Strategies

iNew Medicine, EarlyView.
This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin, Xianfeng Yu, Yayu Wang, Xiaohan Song, Yuehua Wang, Zhixin Wang, Wei Miao, Xudong Yang, Jiajia Zhu, Xiaoqun Zhu, Maria‐Trinidad Herrero   +10 more
wiley   +1 more source

The role of the endocannabinoid system in managing neuropsychiatric symptoms in Alzheimer's disease. [PDF]

Front Psychiatry
Rao JS, Alejandra Tangarife M, Venegas MM, Forero B, González Tamayo LL, Escobar-Gallego JP, Rodríguez-Soacha DA, Ferreiros A, Mukunda R.   +8 more
europepmc   +1 more source

Normative scores and clinical cut‐offs of the Cyclothymic–Hypersensitive Temperament Questionnaire in adolescence

JCPP Advances, EarlyView.
Abstract Background The Cyclothymic–Hypersensitive Temperament (CHT) is a multidimensional, transdiagnostic affective disposition characterized by mood instability, interpersonal sensitivity, heightened emotional reactivity and impulsive behaviors. The CHT Questionnaire (CHTQ) currently lacks of normative references and empirically derived thresholds ...
Anna Pezzella, Vincenzo Paolo Senese, Gabriele Masi, Annarita Milone, Giulia Mutti, Pietro Buono, Gianluca Sesso, Carmela Bravaccio, Raffaella Iuliano, Gennaro Catone, Simone Pisano   +10 more
wiley   +1 more source

The role of rare copy number variants in early‐onset depression

JCPP Advances, EarlyView.
Abstract Background Depression is a highly heterogeneous condition. Depression with an onset in childhood and early adolescence has a worse clinical course, is more heritable, and shows a lower genetic correlation with other depression subtypes, than does later‐onset depression.
Charlotte A. Dennison, Ida Sønderby, Miguel Garcia‐Argibay, Victoria Powell, Amy Shakeshaft, Lucy Riglin, Elliott Rees, Michael O’Donovan, Henrik Larsson, Ole Andreassen, Alexandra Havdahl, Joanna Martin, Anita Thapar   +12 more
wiley   +1 more source