Results 1 to 10 of about 69,987 (253)
Targeting central immune signaling enhances the effects of methylphenidate in alleviating apathy-like behavior in 5xFAD mice [PDF]
Scientific ReportsBeyond cognitive impairment, Alzheimer’s disease (AD) is frequently accompanied by apathy, the most prevalent and burdensome neuropsychiatric symptom (NPS).
Raisa Monteiro +4 more
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Brain Stimulation, 2023 Background: Apathy is reported after subthalamic nucleus deep brain stimulation (STN DBS) and associated with a decreased quality of life in Parkinson's disease (PD) patients.
T.J.C. Zoon +7 more
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A data‐driven examination of apathy and depressive symptoms in dementia with independent replication
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023 Apathy is one of the most common neuropsychiatric symptoms (NPS) and is associated with poor clinical outcomes. Research that helps define the apathy phenotype is urgently needed, particularly for clinical and biomarker studies.
Miguel Vasconcelos Da Silva +6 more
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Dimensions of apathy in Parkinson's disease
Brain and Behavior, 2023 Introduction Apathy is one of the most common neuropsychiatric manifestations in Parkinson's disease (PD). Recent proposals consider apathy as a multidimensional construct, which can manifest in behavioral, cognitive, emotional, and/or social dimensions.
Nasya Thompson +4 more
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Associations, overlaps and dissociations between apathy and fatigue
Scientific Reports, 2022 Apathy and fatigue have a high prevalence in many pathological populations, but they are also present in healthy adults. The relationship between apathy and fatigue, which are both multidimensional, is still poorly understood. This study aims to describe
Lyne Daumas +6 more
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PLoS ONE, 2021 Apathy is defined as reduction of goal-directed behaviors and a common nuisance syndrome of neurodegenerative and psychiatric disease. The underlying mechanism of apathy implicates changes of the front-striatal circuit, but its precise alteration is ...
Chizuko Hamada +5 more
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Identifying and managing apathy in people with dementia living in nursing homes: a qualitative study
BMC Geriatrics, 2023 Background Although apathy is common in people with dementia and has profound negative effects, it is rarely diagnosed nor specifically treated in nursing homes.
Johanna M. H. Nijsten +5 more
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Translational Psychiatry, 2021 The purpose of this study is to investigate the complex connection between apathy and cognitive decline that remains unclear. A total of 1057 non-dementia elderly from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database received up to 13 ...
Lin Sun +4 more
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Frontiers in Psychology, 2021 Apathy is thought to be an important clinical feature of Parkinson’s disease (PD). However, its prevalence ranges greatly across studies because of differing definitions, assessment tools, and patient inclusion criteria.
Jennifer A. Foley +3 more
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Apathy and APOE in mild behavioral impairment, and risk for incident dementia
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Introduction Mild behavioral impairment (MBI) is a high‐risk state for incident dementia and comprises five core domains including affective dysregulation, impulse dyscontrol, social inappropriateness, psychotic symptoms, and apathy.
Daniella Vellone +5 more
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