Results 61 to 70 of about 1,652,342 (214)

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Hyperpolarization of [1‐13C]Ketoisocaproate‐d2 by Reversible Exchange with Parahydrogen Enables Profiling of Branched‐Chain‐Amino‐Acid Metabolism in Cellulo and in Vivo

Advanced Science, EarlyView.
We report the fast generation of biocompatible solutions of highly 13C‐hyperpolarized (≈11%) partially‐deuterated ketoisocaproate within <6 min using spin‐lock‐induced crossing and reversible exchange with parahydrogen (SLIC‐SABRE). This enables rapid detection of branched‐chain‐amino‐acid transferase 1 (BCAT1) protein expression and investigation of ...
Stefan Petersen, Philipp R. Groß, Paul M. Schmidt, Henri de Maissin, Asitan Rittinger, Robert Willing, Adriana Sacristán‐Martín, Lisa Heß, Jule Koch, Sebastian Lucas, Maxim Zaitsev, Dominik von Elverfeldt, Martin Grashei, Franz Schilling, Jan‐Bernd Hövener, André F. Martins, Max von Delius, Thomas Reinheckel, Andreas B. Schmidt   +18 more
wiley   +1 more source

Influences for Gender Disparity in Academic Neuroradiology

, 2017
Background and Purpose: There has been extensive interest in promoting gender equality within radiology, a predominately male field. In this study, our aim was to quantify gender representation in neuroradiology faculty rankings and determine any related
S. Jalal, M. Castillo, K. Khurshid, P.C. Sanelli, Castillo, M., Ahmadi, M., Sanelli, P. C., Jalal, S., A. Norbash, S. Nicolaou, Chahal, T., Khurshid, K., T. Chahal, M. Ahmadi, F. Khosa, Nicolaou, S., Norbash, A., Khosa, F.   +17 more
core   +1 more source

Population differences in brain morphology and microstructure among Chinese, Malay, and Indian neonates [PDF]

, 2012
We studied a sample of 75 Chinese, 73 Malay, and 29 Indian healthy neonates taking part in a cohort study to examine potential differences in neonatal brain morphology and white matter microstructure as a function of ethnicity using both structural T2 ...
Keith M Godfrey, Abdul-Rahman, M.F., Anqi Qiu, Godfrey, K.M., Saw, S.-M., Muhammad Farid Abdul-Rahman, Peter D Gluckman, Rifkin-Graboi Anne, Kwek Kenneth, Chong, Y.-S., Kenneth Kwek, Michael J Meaney, Gluckman Peter D., Meaney Michael J., Abdul-Rahman Muhammad Farid, Qiu Anqi, Seang-Mei Saw, Bai Jordan, Gluckman, P.D., Rifkin-Graboi, A., Chong, Y.S., Kwek, K., Yap-Seng Chong, Fortier Marielle V., Jordan Bai, Qiu, A., Saw Seang-Mei, Godfrey Keith M., Fortier, M.V., Meaney, M.J., Anne Rifkin-Graboi, Chong Yap-Seng, Marielle V Fortier, Bai, J., Saw, S.M.   +34 more
core   +1 more source

Cerebral Small Vessel Disease in Immune‐Mediated Thrombotic Thrombocytopenic Purpura Patients During the Acute Phase and Disease Remission

American Journal of Hematology, EarlyView.
ABSTRACT Immune‐mediated thrombotic thrombocytopenic purpura (iTTP) is a life‐threatening thrombotic microangiopathy characterized by acute neurological manifestations and long‐term sequelae related to microvascular brain injury. Cerebral small vessel disease (cSVD), detectable on MRI through lacunes, microbleeds, white matter hyperintensities, and ...
Addolorata Truma, Francesco Maria Lo Russo, Giorgio Conte, Ilaria Mancini, Andrea Artoni, Juri Alessandro Giannotta, Barbara Ferrari, Pasquale Agosti, Maria Abbattista, Matteo Gagliardi, Eleonora Piccin, Marco Stroppi, Fabio Maria Triulzi, Flora Peyvandi   +13 more
wiley   +1 more source

Proof of principle for the clinical use of a CE-certified automatic imaging analysis tool in rare diseases studying hereditary spastic paraplegia type 4 (SPG4)

Scientific Reports, 2022
Usage of MR imaging biomarkers is limited to experts. Automatic quantitative reports provide access for clinicians to data analysis. Automated data analysis was tested for usability in a small cohort of patients with hereditary spastic paraplegia type 4 (
Tobias Lindig, Benjamin Bender, Eva Bürkle, Vinod Kumar, Ulrike Ernemann, Ludger Schöls, Tim W. Rattay   +6 more
doaj   +1 more source

Amyloid tracers detect multple binding sites in Alzheimer´s disease brain tissue. [PDF]

, 2013
Imaging fibrillar amyloid-β deposition in the human brain in vivo by positron emission tomography has improved our understanding of the time course of amyloid-β pathology in Alzheimer’s disease. The most widely used amyloid-β imaging tracer so far is 11C-
Nordberg, A,, Ni, Ruiqing, Marutle, Amelia, Gillberg, P-G, Marutle, A,, Bergfors, A, Nordberg, Agneta, Gillberg, Per-Göran, Bergfors, Assar, Ni, R,   +9 more
core   +1 more source

Brain Parcellation Repeatability and Reproducibility Using Conventional and Quantitative 3D MR Imaging

, 2023
BACKGROUND AND PURPOSE: Automatic brain parcellation is typically performed on dedicated MR imaging sequences, which require valuable examination time.
Tisell, Anders,, Lundberg, Peter,, P. Lundberg, A. Tisell, J.B.M. Warntjes, Warntjes, Marcel Jan Bertus,   +5 more
core   +1 more source

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source

Evaluating Biases and Quality Issues in Intermodality Image Translation Studies for Neuroradiology: A Systematic Review [PDF]

American Journal of Neuroradiology.
90779480, 立川, 裕之, 植田, 大樹, 29801, 29766, Tatekawa, Hiroyuki, 80303824, Walston, Shannon L., Miki, Yukio, Takita, Hirotaka, 29792, 90779505, 29784, 40712253, Ueda, Daiju, 三木, 幸雄, 田北, 大昂   +16 more
core   +2 more sources