Results 71 to 80 of about 12,549 (250)

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes [PDF]

, 2015
BACKGROUND: GABAA receptor subunit composition has a profound effect on the receptor's physiological and pharmacological properties. The receptor β subunit is widely recognised for its importance in receptor assembly, trafficking and post-translational ...
Smart, TG, Villumsen, IS, Wellendorph, P
core   +1 more source

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, EarlyView.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Pre‐anaesthetic risk assessment and management of dogs with myxomatous mitral valve disease: a spectrum of care narrative review

Journal of Small Animal Practice, EarlyView.
Myxomatous mitral valve disease, an acquired valvular degeneration, is the most common cardiac disorder in dogs, affecting approximately 10% of dogs in primary care veterinary practice. Dogs with myxomatous mitral valve disease frequently require anaesthesia for routine procedures.
I. Levinzon, L. Köster, E. Vettorato, A. H. Estrada   +3 more
wiley   +1 more source

A narrative review of potential neural repair poststroke: Decoction of Chinese angelica and peony in regulating microglia polarization through the neurosteroid pathway

Brain Circulation
Ischemic stroke is a major global health crisis, characterized by high morbidity and mortality rates. Although there have been significant advancements in treating the acute phase of this condition, there remains a pressing need for effective treatments ...
Linhui Qin, Peter Kamash, Yong Yang, Yuchuan Ding, Changhong Ren   +4 more
doaj   +1 more source

Lipidomics of human umbilical cord serum : identification of unique sterol sulfates [PDF]

, 2017
Aim: There are currently limited lipidomics data for human umbilical cord blood. Therefore, the lipidomes of cord sera from six newborns and sera from six nonpregnant females were compared.
Knip, Jan Mikael, Siljander, Heli Tuija Annika, Wood, Paul   +2 more
core   +1 more source

Menstrual cycle effects on sex differences in motor control during dynamic balance perturbations

Experimental Physiology, EarlyView.
Abstract This study investigated sex differences in neuromuscular responses during dynamic balance perturbations and isometric maximal voluntary contractions (IMVCs) by examining if menstrual cycle (MC) phase and the fluctuations in endogenous hormones influence the observation of sex differences.
Samuli Nevanperä, Ritva S. Mikkonen, Simon Walker, Jarmo M. Piirainen   +3 more
wiley   +1 more source

Alpha‐adrenergic mediated changes in blood pressure variability after hypoxia‐ischaemia in preterm fetal sheep

The Journal of Physiology, EarlyView.
Abstract figure legend Clinical detection of brain injury in preterm infantsremains a significant challenge. We investigated whether evolving brain injuryafter severe hypoxia‐ischaemia (HI) in chronically instrumented preterm fetalsheep is associated with dynamic changes in arterial blood pressure variability(BPV) and tested the hypothesis that post‐HI
Simerdeep K. Dhillon, Michael J. Beacom, Victoria J. King, Masahiro Nakao, Olivia J. Lear, Chrisopher A. Lear, Benjamin A. Lear, Joanne O. Davidson, Alistair J. Gunn, Laura Bennet   +9 more
wiley   +1 more source

Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders

Life
Pregnane neuroactive steroids, notably allopregnanolone and pregnenolone, exhibit efficacy in mitigating inflammatory signals triggered by toll-like receptor (TLR) activation, thus attenuating the production of inflammatory factors.
Irina Balan, Giorgia Boero, Samantha Lucenell Chéry, Minna H. McFarland, Alejandro G. Lopez, A. Leslie Morrow   +5 more
doaj   +1 more source