Results 111 to 120 of about 242,018 (356)

Negative myoclonus as a manifestation of cefepime neurotoxicity

Clinical Case Reports
Key Clinical Message Negative myoclonus may present in the early stages of cefepime neurotoxicity. Cefepime neurotoxicity typically presents as reduced consciousness, myoclonus, and seizures; however, negative myoclonus is uncommon.
Daichi Umemoto, Hirokazu Kuroda, Hiroaki Nishioka   +2 more
doaj   +1 more source

Short-course metronidazole-induced reversible acute neurotoxicity in a renal transplant recipient

Saudi Journal of Kidney Diseases and Transplantation, 2018
Neurotoxic manifestations due to chronic metronidazole intake are well known, but neurotoxicity due to short-term use of metronidazole is very rare. We present a case of acute neurotoxicity due to short course of injectable metronidazole given in usual ...
Pavitra Manu Dogra, Anil Kumar Bhatt, Sanjay Kumar Agarwal, Dipankar Bhowmik   +3 more
doaj   +1 more source

The competitive NMDA antagonist CPP protects substantia nigra neurons from MPTP-induced degeneration in primates [PDF]

, 1993
Degeneration of nigrostriatal dopaminergic neurons is the primary histopathological feature of Parkinson's disease. The neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a neurological syndrome in man and non-human primates very ...
Burg, M., Horowski, R., Kalveram, K. T., Lange, Klaus W., Löschmann, P. A., Riederer, Peter, Sofic, E., Wachtel, H.   +7 more
core   +1 more source

Massage‐Mimicking Nanosheets Mechanically Reorganize Inter‐organelle Contacts to Restore Mitochondrial Functions in Parkinson's Disease

Advanced Science, EarlyView.
Parkinson's disease (PD) progression is aggravated by disrupted inter‐organelle contacts, which are influenced by mechanical forces. NanoMassage, 200 nm PEGylated black phosphorus nanosheets, deliver targeted mechanical stimulation to neural cells.
Tianqi Li, Liwen Huang, Chenxiao Guo, Jing Ren, Xi Chen, Yachu Ke, Zengyu Xun, Wenzhuo Hu, Yilin Qi, Heping Wang, Zhongying Gong, Xing‐Jie Liang, Xue Xue   +12 more
wiley   +1 more source

Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity [PDF]

, 2003
Although the accumulation of the neurotoxic peptide {beta} amyloid ({beta}A) in the CNS is a hallmark of Alzheimer's disease, the mechanism of {beta}A neurotoxicity remains controversial.
Abramov, A.Y., Canevari, L., Duchen, M.R.   +2 more
core   +1 more source

A Facile Strategy to Restore the Optic Nerve Functionality Using an Injectable Conducting Hydrogel

Advanced Science, EarlyView.
An injectable conductive polymer hydrogel from poly (3,4‐ethylenedioxythiophene) (PEDOT) is developed to facilitate the recovery of electrophysiological function in injured optic nerve. The hydrogel can be injected directly at the injury site and spontaneously gel in place.
Changchun Yu, Yandi Zhou, Shuang Yao, Ziyi Wang, Sihao Ye, Rubing Qi, Hai Hu, Keke Liu, Yabo Wu, Tom Lawson, Lu Yan, Yong Liu, Wencan Wu   +12 more
wiley   +1 more source

Evidence of emerging BBB changes in mid‐age apolipoprotein E epsilon‐4 carriers

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
This study demonstrated a tendency towards BBB permeability in APOEε4 participants emerging from mid‐age, with quantitative differences observable on a number of the measures. Results from this study may help identify at‐risk populations at an early stage which will be crucial in facilitating the development of early interventions to change the ...
Nourah M. Alruwais, Jenifer M. Rusted, Naji Tabet, Nicholas G. Dowell   +3 more
wiley   +1 more source

Ganglioside-monosialic acid (GM1) prevents oxaliplatin-induced peripheral neurotoxicity in patients with gastrointestinal tumors

World Journal of Surgical Oncology, 2013
Background Oxaliplatin, an effective antineoplastic agent againstgastrointestinal tumors, can cause severe peripheral neurotoxicity, which seriously limits its clinical application.
Zhu Yanyun, Yang Junlan, Jiao Shunchang, Ji Tiefeng   +3 more
doaj   +1 more source

A Brainer on Neurotoxicity [PDF]

Frontiers in Toxicology, 2020
Ellen Fritsche, Helena T. Hogberg
openaire   +3 more sources

Oxytocin‐Mediate Modulation of Splenic Immunosuppression in Chronic Social Stress Through Neuroendocrine Pathways

Advanced Science, EarlyView.
Chronic social stress elevates oxytocin levels, leading to immunosuppression by enhancing regulatory T‐cell activity and promoting anti‐inflammatory macrophage polarization in the spleen. Blocking oxytocin signaling reverses these effects but worsens stress‐induced behavioral disorders and reduces survival rates. This highlights oxytocin's dual role in
Yi‐Shu Zhang, Hai‐Chao Chen, Jia‐Xin Cao, Si‐Wei Zhou, Yue‐Zhang Ma, Yu‐Hong Jing   +5 more
wiley   +1 more source