Results 21 to 30 of about 171,196 (309)

Amoxicillin-Induced Neurotoxicity: Contribution of a Healthcare Data Warehouse to the Determination of a Toxic Concentration Threshold

Antibiotics, 2023
Background: Amoxicillin (AMX)-induced neurotoxicity is well described and may be associated with AMX overexposure. No neurotoxic concentration threshold has been determined thus far.
Sébastien Lalanne, Guillaume Bouzillé, Camille Tron, Matthieu Revest, Elisabeth Polard, Eric Bellissant, Marie-Clémence Verdier, Florian Lemaitre   +7 more
doaj   +1 more source

MPTP Neurotoxicity: Actions, Mechanisms, and Animal Modeling of Parkinson’s Disease

, 2023
The study of neurotoxicity induced by MPTP led to drastically change the perspective on Parkinson’s disease. In fact, the selective neurotoxicity induced by MPTP rejuvenated PD research and generated a number of studies aimed at elucidating the ...
Ferrucci M., Fornai F.
core   +1 more source

A new approach on lithium-induced neurotoxicity using rat neuronal cortical culture: Involvement of oxidative stress and lysosomal/mitochondrial toxic Cross-Talk

Main Group Metal Chemistry, 2020
Lithium (Li) is a widely-used medication for the treatment of patients with bipolar disorder. Li causes different complications. One of the most important adverse effects of Li is neurotoxicity.
Yousefsani Bahareh Sadat, Askian Romina, Pourahmad Jalal   +2 more
doaj   +1 more source

PAC1 Receptor Mediates Electroacupuncture-Induced Neuro and Immune Protection During Cisplatin Chemotherapy

Frontiers in Immunology, 2021
Platinum-based chemotherapy is an effective treatment used in multiple tumor treatments, but produces severe side effects including neurotoxicity, anemia, and immunosuppression, which limits its anti-tumor efficacy and increases the risk of infections ...
Shanshan Li, Jin Huang, Yi Guo, Yi Guo, Yi Guo, Jiaqi Wang, Shanshan Lu, Bin Wang, Yinan Gong, Siru Qin, Suhong Zhao, Shenjun Wang, Shenjun Wang, Shenjun Wang, Yangyang Liu, Yangyang Liu, Yangyang Liu, Yuxin Fang, Yuxin Fang, Yuxin Fang, Yongming Guo, Yongming Guo, Yongming Guo, Zhifang Xu, Zhifang Xu, Zhifang Xu, Luis Ulloa   +26 more
doaj   +1 more source

Articaine and neurotoxicity – a review

British Dental Journal, 2017
The biochemical composition of articaine differs from other amide anaesthetics. The lipophilic part of articaine consists of a thiophene ring, whereas other amide anaesthetics contain a benzene ring. When used correctly, local anaesthetics are remarkably safe. However, all local anaesthetics are potentially neurotoxic.
Hopman, A.J.G., Baart, J.A., Brand, H.S.
openaire   +3 more sources

The Role of Ionic Homeostasis in Cisplatin-Induced Neurotoxicity: A Preliminary Study

Eurasian Journal of Medicine, 2019
Objective: The aim of the present study was to investigate the role of ionic homeostasis in cisplatin (cis-diamminedichloroplatinum (II), CDDP)-induced neurotoxicity. CDDP is a severely neurotoxic antineoplastic agent that causes neuronal excitotoxicity.
Cigdem Cengelli Unel, Kevser Erol
doaj   +1 more source

Phase III randomized, placebo‐controlled, double‐blind study of monosialotetrahexosylganglioside for the prevention of oxaliplatin‐induced peripheral neurotoxicity in stage II/III colorectal cancer

Cancer Medicine, 2020
Background Monosialotetrahexosylganglioside (GM1) is a neuroprotective glycosphingolipid that repairs nerves. Oxaliplatin‐based chemotherapy is neurotoxic.
De‐shen Wang, Zhi‐qiang Wang, Gong Chen, Jie‐wen Peng, Wei Wang, Yan‐hong Deng, Feng‐hua Wang, Jian‐wei Zhang, Han‐lin Liang, Fen Feng, Chuan‐bo Xie, Chao Ren, Ying Jin, Si‐mei Shi, Wen‐hua Fan, Zhen‐hai Lu, Pei‐rong Ding, Feng Wang, Rui‐hua Xu, Yu‐hong Li   +19 more
doaj   +1 more source

Paresthesia in dentistry: The ignored neurotoxicity of local anesthetics

Heliyon, 2023
Local anesthetics are frequently used by dentists to relieve localized discomfort of the patient and improve treatment conditions. The risk of paresthesia after local anesthesia is frequently encountered in dental clinics.
Yong-zhen Tan, Rong-jia Shi, Bo-wen Ke, Ya-ling Tang, Xin-hua Liang   +4 more
doaj   +1 more source

Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route

Molecular Therapy: Nucleic Acids, 2023
Antisense oligonucleotides (ASOs) are promising therapeutics for intractable central nervous system (CNS) diseases. For this clinical application, neurotoxicity is one of the critical limitations.
Chunyan Jia, Su Su Lei Mon, Ying Yang, Maho Katsuyama, Kie Yoshida-Tanaka, Tetsuya Nagata, Kotaro Yoshioka, Takanori Yokota   +7 more
doaj   +1 more source

Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome Neurotoxicity [PDF]

, 2015
U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 A mu M aminochrome increases GSTM2 expression by 2.1-fold (P < 0.001) at 3 h.
Segura-Aguilar, Juan, Segura Aguilar, Juan, Paris, Irmgard, Muñoz, Patricia, Urriola Cuevas, Carlos, Paris Pizarro, Irmgard, Cuevas, Carlos, Huenchuguala, Sandro, Villa, Mónica, Mannervik, Bengt, Mannervik, Bengt,   +10 more
core   +1 more source