Results 51 to 60 of about 270,958 (352)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Neurotoxicity of Sri Lankan Krait (Bungarus ceylonicus) and Common Krait (Bungarus caeruleus) Venoms and Their Neutralisation by Commercial Antivenoms In Vitro

Toxins
The common krait (Bungarus caeruleus) and the endemic Sri Lankan krait (B. ceylonicus) are two species of krait responsible for envenomings in Sri Lanka that result in progressive neuromuscular paralysis. We characterised the in vitro neurotoxicity of B.
Jithmi Galappaththige, Geoffrey K. Isbister, Kalana Maduwage, Wayne C. Hodgson, Anjana Silva   +4 more
doaj   +1 more source

Central neurotoxicity of immunomodulatory drugs in multiple myeloma

Hematology Reports, 2015
Immunomodulatory drugs (IMiDs) currently used in the treatment of multiple myeloma, are thalidomide, lenalidomide and pomalidomide. One of the most common side effects of thalidomide is neurotoxicity, predominantly in the form of peripheral neuropathy ...
Urmeel H. Patel, Muhammad A. Mir, Jeffrey K. Sivik, Divisha Raheja, Manoj K. Pandey, Giampaolo Talamo   +5 more
doaj   +1 more source

Paclitaxel, but Not Cisplatin, Affects Satellite Glial Cells in Dorsal Root Ganglia of Rats with Chemotherapy-Induced Peripheral Neurotoxicity

Toxics, 2023
Chemotherapy-induced peripheral neurotoxicity is one of the most common dose-limiting toxicities of several widely used anticancer drugs such as platinum derivatives (cisplatin) and taxanes (paclitaxel).
Eleonora Pozzi, Elisa Ballarini, Virginia Rodriguez-Menendez, Annalisa Canta, Alessia Chiorazzi, Laura Monza, Mario Bossi, Paola Alberti, Alessio Malacrida, Cristina Meregalli, Arianna Scuteri, Guido Cavaletti, Valentina Alda Carozzi   +12 more
doaj   +1 more source

Comparative Analysis Of Zebrafish And Planarian Model Systems For Developmental Neurotoxicity Screens Using An 87-Compound Library [PDF]

, 2019
There is a clear need to establish and validate new methodologies to more quickly and efficiently screen chemicals for potential toxic effects, particularly on development. The emergence of alternative animal systems for rapid toxicology screens presents
Collins, Eva-Maria S., Hagstrom, D., Tanguay, R., Truong, L., Zhang, S.   +4 more
core   +1 more source

Minimal clinically important difference of the EORTC QLQ-CIPN20 for worsening peripheral neuropathy in patients receiving neurotoxic chemotherapy. [PDF]

, 2019
Context/objectivesThis is the first study to determine the minimal clinically important difference (MCID) of the European Organisation of Research and Treatment of Cancer Quality of Life Questionnaire-CIPN twenty-item scale (EORTC QLQ-CIPN20), a ...
Ang, Emily, Au, Joseph SK, Bandla, Aishwarya, Chan, Alexandre, Chan, Choi Wan, Cheng, Hui Lin, Farrell, Carole, Leung, Kwun To, Li, Yu Chung, Loh, Kiley WJ, Lopez, Violeta, Molassiotis, Alex, Ng, Chiu Chin, Suen, Lorna, Sundar, Raghav, Wong, Kam-Hung, Yeo, Fiona, Yorke, Janelle   +17 more
core   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Methotrexate-induced acute neurotoxicity in patients with osteosarcoma: a case report

Journal of Medical Case Reports
Background Methotrexate is commonly used to treat osteosarcoma and acute lymphoblastic leukemia. Methotrexate can rarely cause neurotoxicity with a wide range of presentations including seizure, hemiparesis, dysarthria, dysphagia, and more.
Olivia L. Makos, Nicole A. Shonka, Kealy M. Marth, Shawna L. Stricker, Mark Keiper, Makayla E. Schissel   +5 more
doaj   +1 more source

Patient‐reported tolerability of veliparib combined with cisplatin and etoposide for treatment of extensive stage small cell lung cancer: Neurotoxicity and adherence data from the ECOG ACRIN cancer research group E2511 phase II randomized trial

Cancer Medicine, 2020
Objectives The ECOG‐ACRIN Cancer Research Group trial E2511 recently demonstrated a potential benefit for the addition of veliparib to cisplatin‐etoposide (CE) in patients with extensive stage small cell lung cancer (ES‐SCLC) in a phase II randomized ...
Laurie E. Steffen McLouth, Fengmin Zhao, Taofeek K. Owonikoko, Josephine L. Feliciano, Nisha A. Mohindra, Suzanne E. Dahlberg, James L. Wade III, Gordan Srkalovic, Bradley W. Lash, Joseph W. Leach, Ticiana A. Leal, Charu Aggarwal, David Cella, Suresh S. Ramalingam, Lynne I. Wagner   +14 more
doaj   +1 more source

Diesel Exhaust Activates & Primes Microglia: Air Pollution, Neuroinflammation, & Regulation of Dopaminergic Neurotoxicity [PDF]

, 2011
BACKGROUND: Air pollution is linked to central nervous system disease, but the mechanisms responsible are poorly understood. OBJECTIVES: Here, we sought to address the brain-region-specific effects of diesel exhaust (DE) and key cellular mechanisms ...
Block, Michelle L, Duke, Laura, Johnson, Jo Anne, Kodavanti, Prasada, Kodavanti, Urmila, Levesque, Shannon, Lull, Melinda E., Stadler, Krisztian, Surace, Michael J., Taetzsch, Thomas, Wagner, Alison   +10 more
core   +1 more source