Results 51 to 60 of about 171,196 (309)

Etiological Profile and Clinical Outcomes Of Acute Neurotoxicity During Pediatric ALL Treatment in a Developing Country

Pakistan Armed Forces Medical Journal
  Objective: To determine the causes, clinical manifestations, and consequences of acute neurotoxicity in pediatric patients undergoing therapy for acute lymphoblastic leukemia (ALL). Study Design: A prospective longitudinal study.
Sundus Hashmani, Anushe Mohsin Feroze, Zohra Rafique, Syed Ahmer Hamid, Muhammad Rafie Raza, Muhammad Shamvil Ashraf   +5 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

The role of neuroimaging in neurotoxicity after chimeric antigen receptor T-cell therapy

Therapeutic Advances in Neurological Disorders
Chimeric antigen receptor T-cell (CAR-T) therapy has become an established treatment for several haematological malignancies in relapse and is being evaluated for new indications.
Arian Lasocki, Simon J. Harrison, Michael Dickinson, Tomas Kalincik   +3 more
doaj   +1 more source

Biomarkers of cytokine release syndrome and neurotoxicity related to CAR-T cell therapy

Biomarker Research, 2018
Severe cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T cell (CAR-T) therapy can be life-threatening in some cases, and management of those toxicities is still a great challenge for physicians.
Zhenguang Wang, Weidong Han
doaj   +1 more source

Patient‐reported tolerability of veliparib combined with cisplatin and etoposide for treatment of extensive stage small cell lung cancer: Neurotoxicity and adherence data from the ECOG ACRIN cancer research group E2511 phase II randomized trial

Cancer Medicine, 2020
Objectives The ECOG‐ACRIN Cancer Research Group trial E2511 recently demonstrated a potential benefit for the addition of veliparib to cisplatin‐etoposide (CE) in patients with extensive stage small cell lung cancer (ES‐SCLC) in a phase II randomized ...
Laurie E. Steffen McLouth, Fengmin Zhao, Taofeek K. Owonikoko, Josephine L. Feliciano, Nisha A. Mohindra, Suzanne E. Dahlberg, James L. Wade III, Gordan Srkalovic, Bradley W. Lash, Joseph W. Leach, Ticiana A. Leal, Charu Aggarwal, David Cella, Suresh S. Ramalingam, Lynne I. Wagner   +14 more
doaj   +1 more source

Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived fas ligand [PDF]

, 2005
Activated microglia may be detrimental to neuronal survival in a number of neurodegenerative diseases. Thus, strategies that reduce microglial neurotoxicity may have therapeutic benefit.
Taylor, DL, Pocock, JM, Jones, F, Kubota, ESFCS   +3 more
core  

Hypericum perforatum L. Nanoemulsion Mitigates Cisplatin-Induced Chemobrain via Reducing Neurobehavioral Alterations, Oxidative Stress, Neuroinflammation, and Apoptosis in Adult Rats

, 2023
Cisplatin (Cis) is a potent chemotherapeutic agent; however, it is linked with oxidative stress, inflammation, and apoptosis, which may harmfully affect the brain. Hypericum perforatum L.
Heba M. A. Khalil, Nancy S. Younis, Riham A. El-Shiekh, Mohamed I. Fahmy, Hanan M. A. El Henafy, Alaa F. Bakr, Islam A. Khalil   +6 more
core   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish

Frontiers in Genetics, 2021
Adverse outcomes that result from chemical toxicity are rarely caused by dysregulation of individual proteins; rather, they are often caused by system-level perturbations in networks of molecular events. To fully understand the mechanisms of toxicity, it
Roman A. Li, Roman A. Li, Marja Talikka, Sylvain Gubian, Colette vom Berg, Florian Martin, Manuel C. Peitsch, Julia Hoeng, Anze Zupanic, Anze Zupanic   +9 more
doaj   +1 more source

Epigenetics and Methylmercury-Induced Neurotoxicity, Evidence from Experimental Studies

, 2023
MeHg is an environmental neurotoxin that can adversely affect the development of the nervous system. The molecular integrity of chromatin in the nucleus is an important target of MeHg. Low levels of MeHg trigger epigenetic mechanisms that may be involved
Aaron Bowman, Santamaria, Abel, Alexey Tinkov, Michael Aschner, Joao B. T. Rocha, Rocha, Joao B. T., Alexey A. Tinkov, Joao Rocha, Aaron B. Bowman, Tinkov, Alexey A., Chen, Wen, Tao Ke, Aschner, Michael, Anatoly V. Skalny, Ke, Tao, Abel Santamaria, Wen Chen, Bowman, Aaron B., Anatoly Skalny, Skalny, Anatoly V.   +19 more
core   +1 more source