Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived fas ligand [PDF]
, 2005 Activated microglia may be detrimental to neuronal survival in a number of neurodegenerative diseases. Thus, strategies that reduce microglial neurotoxicity may have therapeutic benefit.
Jones, F +3 more
core
Nimesulide limits kainate-induced oxidative damage in the rat hippocampus [PDF]
, 2000 Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-
Ajamieh, Hussam +4 more
core +1 more source
Modeling Amyloid Beta Peptide Insertion into Lipid Bilayers [PDF]
, 2003 Inspired by recent suggestions that the Alzheimer's amyloid beta peptide (A beta) can insert into cell membranes and form harmful ion channels, we model insertion of the 40 and 42 residue forms of the peptide into cell membranes using a Monte Carlo code which is specific at the amino acid level.
arxiv +1 more source
Chronic cocaine enhances release of neuroprotective amino acid taurine: a microdialysis study [PDF]
, 2008 Cocaine inhibits high-affinity neurotransmitter uptake at the presynaptic nerve terminals to increase synaptic levels of dopamine, norepinephrine and serotonin^1^. This increase of synaptic dopamine may cause neurotoxicity^2,3^.
Eitan Freedman +5 more
core +1 more source
Lipid peroxidation and apoptotic response in rat brain areas induced by long-term administration of nandrolone: the mutual crosstalk between ROS and NF-kB [PDF]
, 2016 The aim of this study was to evaluate the played by oxidative stress in the apoptotic response in different brain areas of rats chronically treated with supra-physiological doses of nandrolone decanoate (ND).
Busardo', FRANCESCO PAOLO +9 more
core +2 more sources
Indian Journal of Clinical Biochemistry, 2015 The lead exposure is a public health concern, especially in early childhood as children are more at risk because of increased hand to mouth activity and absorb about half of an oral dose of water-soluble lead [1]. Childhood lead exposure is estimated to contribute to 600,000 new cases of children with intellectual disabilities every year with 99 % of ...
Shailja Chambial +2 more
openaire +3 more sources
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose An evaluation of the accuracy, safety, and efficiency of the Halcyon ring delivery system (RDS) for stereotactic radiosurgery (SRS) treatment to relatively small (1–3 cm) brain lesions. Methods After completing the extensive in‐house quality assurance checks including Winston–Lutz test and independent dose verification via MD Anderson ...
Kate Hazelwood +5 more
wiley +1 more source
Current View in Platinum Drug Mechanisms of Peripheral Neurotoxicity
Toxics, 2015 Peripheral neurotoxicity is the dose-limiting factor for clinical use of platinum derivatives, a class of anticancer drugs which includes cisplatin, carboplatin, and oxaliplatin.
Alessia Chiorazzi +2 more
doaj +1 more source
Diesel Exhaust Activates & Primes Microglia: Air Pollution, Neuroinflammation, & Regulation of Dopaminergic Neurotoxicity [PDF]
, 2011 BACKGROUND: Air pollution is linked to central nervous system disease, but the mechanisms responsible are poorly understood. OBJECTIVES: Here, we sought to address the brain-region-specific effects of diesel exhaust (DE) and key cellular mechanisms ...
Block, Michelle L +10 more
core +1 more source
A Novel Genetic Screen Identifies Modifiers of Age-Dependent Amyloid β Toxicity in the Drosophila Brain [PDF]
, 2017 The accumulation of amyloid β peptide (Aβ) in the brain of Alzheimer's disease (AD) patients begins many years before clinical onset. Such process has been proposed to be pathogenic through the toxicity of Aβ soluble oligomers leading to synaptic ...
Belfiori Carrasco, Lautaro Francisco +5 more
core +1 more source