Results 111 to 120 of about 105,668 (383)

Closed Genome Sequence of Chryseobacterium piperi Strain CTMT/ATCC BAA-1782, a Gram-Negative Bacterium with Clostridial Neurotoxin-Like Coding Sequences

Genome Announcements, 2017
Clostridial neurotoxins, including botulinum and tetanus neurotoxins, are among the deadliest known bacterial toxins. Until recently, the horizontal mobility of this toxin gene family appeared to be limited to the genus Clostridium.
T. Wentz, T. Muruvanda, S. Lomonaco, Nagarajan Thirunavukkarasu, M. Hoffmann, M. Allard, David R. Hodge, S. Pillai, T. Hammack, E. Brown, S. Sharma   +10 more
semanticscholar   +1 more source

CO2‐Responsive Smart Wood Scaffold for Natural Organic Matter Removal without Secondary Pollution

Advanced Materials, EarlyView.
A CO2‐responsive smart wood scaffold is developed for sustainable water purification, achieving efficient natural organic matter (NOM) removal and microbial disinfection without secondary pollution. The CO2‐responsive polymer coating undergoes protonation upon CO2 exposure, enabling strong cation−π interactions with NOM.
Lin Yang, Yuanyuan Wang, Yongxiang Sun, Ruiquan Yu, Yifu Chu, Yuan Yao, Chenxu Liu, Ning Li, Lingyun Chen, Jifang Liu, Ziqian Zhao, Hongbo Zeng   +11 more
wiley   +1 more source

Gulf War Syndrome: A role for organophosphate induced plasticity of locus coeruleus neurons [PDF]

, 2011
Gulf War syndrome is a chronic multi-symptom illness that has affected about a quarter of the deployed veterans of the 1991 Gulf War. Exposure to prolonged low-level organophosphate insecticides and other toxic chemicals is now thought to be responsible.
Andrew L. Varnell, Donald C. Cooper, Jun-li Cao   +2 more
core   +3 more sources

Bioengineered Models of Nerve Regeneration

Advanced Materials Technologies, EarlyView.
Bioengineered nerve regeneration platforms ranging from patterned cell cultures and hydrogels to fibrous scaffolds and microfluidic systems are reviewed, highlighting the complex cellular and biochemical environments essential for nerve repair. Challenges associated with these platforms, such as balancing complexity with throughput and the need for ...
Madalynn Jade Thompson, John Paul Frampton   +1 more
wiley   +1 more source

CIB1 protects against MPTP-induced neurotoxicity through inhibiting ASK1. [PDF]

, 2017
Calcium and integrin binding protein 1 (CIB1) is a calcium-binding protein that was initially identified as a binding partner of platelet integrin αIIb. Although CIB1 has been shown to interact with multiple proteins, its biological function in the brain
Choi, Eui-Ju, Kang, Seongman, Kim, Yeonsil, Kim, Young Mok, Naik, Ulhas P., Parise, Leslie V., Sun, Woong, Yang, Hyun-Suk, Yoon, Kyoung Wan   +8 more
core   +4 more sources

Isolation and Functional Characterization of the Novel Clostridium botulinum Neurotoxin A8 Subtype

PLoS ONE, 2015
Botulism is a severe neurological disease caused by the complex family of botulinum neurotoxins (BoNT). Based on the different serotypes known today, a classification of serotype variants termed subtypes has been proposed according to sequence diversity ...
S. Kull, K. Schulz, J. Strotmeier, S. Kirchner, Tanja Schreiber, A. Bollenbach, P. W. Dabrowski, A. Nitsche, Suzanne R. Kalb, M. B. Dorner, J. Barr, A. Rummel, B. Dorner   +12 more
semanticscholar   +1 more source

Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering

Advanced Therapeutics, EarlyView.
This review covers the mechanical forces experienced by immune cells through cell–cell and cell–extracellular matrix interactions and how these forces influence their receptors and functions. These relationships between forces and cellular functions can be exploited using engineering techniques to modify the physical properties of materials for novel ...
Yu‐Chang Chen, Nghi M. Tran, Kyle H. Vining   +2 more
wiley   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Evaluation of a neurotoxin as an adjunctive treatment modality for the management of gummy smile

Indian Dermatology Online Journal, 2019
Introduction: Excessive gingival display while smiling mars facial aesthetics, this condition is referred to as “gummy smile” (GS). Available literature suggests that Botulinum toxin type A (BTX-A) is effective in the management of excessive gingival ...
Neha Gupta, Sarvraj Kohli
doaj   +1 more source