Results 281 to 290 of about 105,668 (383)

Targeting Ubiquitin‐Specific Protease 7 with Novel 5‐Amino‐Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation

ChemMedChem, EarlyView.
Ubiquitin‐specific protease 7 (USP‐7) is a novel target for anticancer therapy. To further extend the structure–activity relationships of the previously USP‐7 inhibitor STIRUR‐41, a library of 5‐aminopyrazoles is reported. 1d shows a potency comparable to lead compound STIRUR‐41 and promising in silico and in vitro pharmacokinetic properties ...
Matteo Lusardi, Elva Morretta, Andrea Spallarossa, Maria Chiara Monti, Camillo Rosano, Erika Iervasi, Marco Ponassi, Matteo Mori, Fiorella Meneghetti, Chiara Brullo   +9 more
wiley   +1 more source

Case Report: Combination of focal vibration therapy and botulinum toxin injections to treat equinus gait in a child with unilateral spastic cerebral palsy. [PDF]

Front Rehabil Sci
Boulay C, Coq JO, Sangeux M, Authier G, Ulian A, Pradines M, Baude M, Desnous B, Jouve JL, Parratte B, Peltier E, Pesenti S, Gracies JM.   +12 more
europepmc   +1 more source

EPR kinetic studies of superoxide radicals generated during the autoxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium, a bioactivated intermediate of parkinsonian-inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

, 1992
Lun‐Yi Zang, H. P. Misra
openalex   +1 more source

Manganese Neurotoxicity and Familial Disorders of Manganese Transport

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Manganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is required for normal biochemical and physiological processes, manganese excess can lead to significant toxicity, particularly to the ...
Sidney M. Gospe Jr.
wiley   +1 more source

Neuroprotective Activity of Oligomeric Stilbenes from Alpha Grape Stems in In Vitro Models of Parkinson's Disease. [PDF]

Int J Mol Sci
Pislyagin EA, Tarbeeva DV, Yurchenko EA, Menchinskaya ES, Gorpenchenko TY, Pokhilo ND, Kalinovskiy AI, Aminin DL, Fedoreyev SA.   +8 more
europepmc   +1 more source

Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions

Cancer Nexus, EarlyView.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature and complex pathophysiology. Recent breakthroughs in molecular profiling revealed intricate genetic alterations driving tumor progression, necessitating an updated perspective on the ...
Abhimanyu Thakur, Anne Dijkstra
wiley   +1 more source

Recombinant expression of receptor binding domains of all eight subtypes of botulinum neurotoxin type A for generation of antitoxins with broad reactivity. [PDF]

F1000Res
Quynh Pham N, Mai TT, Dang TBA, Huong Tran L, Mai Vu Q, Trong Nguyen C, Thi Phuong Tran A, Dang TNM, Tran VA, Huy Tran T, Tran VK, Quang Le H.   +11 more
europepmc   +1 more source

Low‐Energy Electron‐Induced Dissociation of the Radiosensitizing Agent Sanazole

ChemPlusChem, EarlyView.
Employing mass spectrometry supported by quantum chemical calculations, electron attachment to gas‐phase and microhydrated sanazole, a hypoxic radiosensitizer, is examined. The results suggest that hydration closes and/or slows down the dissociation process and indicates that the initial mechanism of action in a reductive cell environment may be ...
Farhad Izadi, Masoomeh Mahmoodi‐Darian, Thomas F.M. Luxford, Jaroslav Kočišek, Stephan Denifl, Milan Ončák   +5 more
wiley   +1 more source

Crippling konzo in DRC, three generations later [PDF]

, 2014
Banea Mayambu, Jean-Pierre, Diasolua Ngudi, Delphin, Lambein, Fernand   +2 more
core   +1 more source