Results 291 to 300 of about 105,668 (383)

Continuous Intravenous Nimodipine Infusion With Ethanol as Carrier in Aneurysmal Subarachnoid Hemorrhage Does Not Result in Measurable Cerebral Ethanol Levels

Clinical Pharmacology &Therapeutics, EarlyView.
An unimpaired neurological evaluation is essential for detecting delayed cerebral ischemia (DCI) in aneurysmal subarachnoid hemorrhage (aSAH) patients. Nimodipine is currently the only drug approved for DCI prevention. Intravenous nimodipine infusion contains 23.7 vol% ethanol as an excipient, resulting in up to 45 g of ethanol being infused daily ...
Miriam M. Moser, Karl Rössler, Dorian Hirschmann, Leon Gramss, Walter Plöchl, Johannes Herta, Andrea Reinprecht, Markus Zeitlinger, Arthur Hosmann   +8 more
wiley   +1 more source

Botulism Type F: Foodborne or Adult Intestinal Colonization? [PDF]

Gastro Hep Adv
Pourshams I, Kumbham P, Ranga S, Calloway KN, Patil N, Waltenburg MA.   +5 more
europepmc   +1 more source

Characterization of the neurotoxin isolated from a Clostridium baratii strain implicated in infant botulism

, 1992
Juan Antonio Giménez‐Bastida, M A Giménez, Bibhuti R. DasGupta   +2 more
openalex   +1 more source

Role of Ion‐Pair and H‐Bonding in Colorimetric Detection of Insulin Fibrils with Picomolar Sensitivity

ChemPhotoChem, EarlyView.
Ultrasensitive detection (LOD=2 pM) of insulin amyloid fibril is achieved using a hemicyanine dye. A unique feature of amyloid induced dissociation of ion‐pair and solute‐solvent hydrogen bonding has been established to play a pivotal role for dual mode detection of amyloid fibrils.
Ayentika Sen, Aruna K. Mora, Soumitra Kundu, Sukhendu Nath   +3 more
wiley   +1 more source

cDNA deduced amino-acid sequences of two novel Kappa-neurotoxins fromBungarus multicinctus

, 1990
Jean-Marc Danse, Jean-Marie Gamier
openalex   +2 more sources

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Striatal Toe: Too Harmless to Treat? [PDF]

Toxins (Basel)
Jost WH, Berberovic E.
europepmc   +1 more source

Black widow spider α-latrotoxin: a presynaptic neurotoxin that shares structural homology with the glucagon-like peptide-1 family of insulin secretagogic hormones

, 1998
George G. Holz, Joel F. Habener
openalex   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source