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Presynaptic enzymatic neurotoxins
Journal of Neurochemistry, 2006AbstractBotulinum neurotoxins produced by anaerobic bacteria of the genus Clostridium are the most toxic proteins known, with mouse LD50 values in the 1–5 ng/kg range, and are solely responsible for the pathophysiology of botulism. These metalloproteinases enter peripheral cholinergic nerve terminals and cleave proteins of the neuroexocytosis apparatus,
ROSSETTO, ORNELLA +4 more
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Acta Psychiatrica Scandinavica, 1983
The role of toxic substances in causing central nervous system dysfunction is discussed with a focus on effects which are mediated indirectly through other organ systems which affect the brain. Neurochemical measurements of brain function, and the use of neuropharmacological probes of behavior are presented with the examples of lead poisoning, as a ...
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The role of toxic substances in causing central nervous system dysfunction is discussed with a focus on effects which are mediated indirectly through other organ systems which affect the brain. Neurochemical measurements of brain function, and the use of neuropharmacological probes of behavior are presented with the examples of lead poisoning, as a ...
openaire +2 more sources
Neurologic Clinics, 2000
The epidemiology, clinical features, pathology, and mechanisms of action of basal ganglia neurotoxins are reviewed. Manganese, cyanide, hydrogen sulfide, methanol, carbon monoxide, 3-nitropropionic acid, MPTP, and annonaceae alkaloids are discussed. The probable mechanism of action for almost all basal ganglia neurotoxins is inhibition of mitochondrial
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The epidemiology, clinical features, pathology, and mechanisms of action of basal ganglia neurotoxins are reviewed. Manganese, cyanide, hydrogen sulfide, methanol, carbon monoxide, 3-nitropropionic acid, MPTP, and annonaceae alkaloids are discussed. The probable mechanism of action for almost all basal ganglia neurotoxins is inhibition of mitochondrial
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6-Hydroxydopamine: a far from simple neurotoxin
Journal of neural transmission, 2020D. Varešlija +3 more
semanticscholar +1 more source