Results 191 to 200 of about 224,377 (390)

Synthesis of Alpha‐Acyloxy‐(1,2,5‐Oxadiazole‐2‐Oxide) Carboxamides via Passerini Multicomponent Reaction. Evaluation of Nitric Oxide‐Releasing and Anti‐Proliferative Properties

open access: yesJournal of Heterocyclic Chemistry, EarlyView.
The Passerini multicomponent reaction was used to synthesize α‐acyloxy‐(1,2,5‐oxadiazole‐2‐oxide)carboxamides in good to excellent yields (67‐97%) under microwave heating. All compounds were able to release NO in solution, within the concentration range of 0.8–7.4 μM. Antiproliferative activity was investigated against LNCaP, MCF‐7, and SK‐MEL‐28 tumor
Nicolas S. Anjos   +7 more
wiley   +1 more source

Microplastics in Agricultural Soil: Fate, Impacts, and Bioremediation by Earthworms

open access: yesJournal of Plant Nutrition and Soil Science, EarlyView.
Microplastics enter the soil through various means, including the degradation of plastic film mulch, waste from cosmetics industries and municipalities, and the use of bioplastic seed coatings. These microplastics disrupt soil structure, microbial activity, enzyme function, and plant growth.
Sami ur Rehman   +5 more
wiley   +1 more source

STARDEV Study: Neurodevelopmental Trajectory and Long‐Term Outcomes of Patients with Startle Disease/Hyperekplexia

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Although initial clinical presentation of hyperekplexia/startle disease is well known, data regarding long‐term clinical outcomes is lacking. Objectives We provide a long‐term evaluation from clinical and pharmacological perspectives, focusing on neurodevelopmental trajectory. Methods Twenty‐eight patients from nine French hospitals
Diane Pina   +19 more
wiley   +1 more source

Electrophysiological Evidence for Impaired Central Pain Modulation in Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Our study demonstrates electrophysiological evidence of impaired central pain modulation in Parkinson's disease (PD) patients using laser‐evoked potential habituation and quantitative sensory testing. PD patients exhibited reduced habituation to painful stimuli, independent of reported pain or medication.
Dilara Kersebaum   +10 more
wiley   +1 more source

l-Serine links metabolism with neurotransmission

open access: yesProgress in neurobiology, 2020
M. Maugard   +3 more
semanticscholar   +1 more source

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