Results 31 to 40 of about 224,377 (390)
Optical Modulation of Neurotransmission [PDF]
Biophysical Journal, 2013 The computational properties of an isolated neuron have been analyzed in detail by postsynaptic activation with caged compounds. However, new tools are needed to manipulate neurotransmission at individual synapses in order to understand how a neuron integrates physiological stimuli received from presynaptic neurons within a circuit.
Dirk Trauner +3 more
openaire +2 more sources
The GABA-Withdrawal Syndrome: A Model of Local Status Epilepticus
Neural Plasticity, 2000 The GABA-withdrawal syndrome (GWS) is a model of local status epilepticus following the interruption of a chronic GABA infusion into the rat somatomotor cortex.
Carmen Silva-Barrat +2 more
doaj +1 more source
Optical modulation of neurotransmission using calcium photocurrents through the ion channel LiGluR
Frontiers in Molecular Neuroscience, 2013 A wide range of light-activated molecules (photoswitches and phototriggers) have been used to the study of computational properties of an isolated neuron by acting pre and postsynaptically.
Mercè eIzquierdo-Serra +5 more
doaj +1 more source
Activity-dependent modulation of neural circuit synaptic connectivity
Frontiers in Molecular Neuroscience, 2009 In many nervous systems, the establishment of neural circuits is known to proceed via a two-stage process; 1) early, activity-independent wiring to produce a rough map characterized by excessive synaptic connections, and 2) subsequent, use-dependent
Charles R Tessier, Kendal Broadie
doaj +1 more source
Organic Cation Transporter 3 (OCT3) Is Localized to Intracellular and Surface Membranes in Select Glial and Neuronal Cells Within the Basolateral Amygdaloid Complex of Both Rats and Mice [PDF]
, 2016 Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin. OCT3 is expressed widely throughout the
Chan, June +3 more
core +2 more sources
EMBO Molecular Medicine, 2018 Normal hearing and synaptic transmission at afferent auditory inner hair cell (IHC) synapses require otoferlin. Deafness DFNB9, caused by mutations in the OTOF gene encoding otoferlin, might be treated by transferring wild‐type otoferlin cDNA into IHCs ...
Hanan Al‐Moyed +5 more
doaj +1 more source
Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]
, 2014 Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean +3 more
core +2 more sources
Food-derived Acetylcholinesterase Inhibitors as Potential Agents against Alzheimer’s Disease
eFood, 2021 Acetylcholinesterase (AChE) is a critical enzyme involved in nerve functions and signal transmission within the brain. However, during aging, excessive AChE activity often leads to rapid and progressive depletion of acetylcholine (ACh), the major ...
Rotimi E. Aluko
doaj +1 more source
, 2014 Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust +15 more
core +2 more sources
Relationships between Mitochondrial Dysfunction and Neurotransmission Failure in Alzheimer’s Disease
Aging and Disease, 2020 Besides extracellular deposition of amyloid beta and formation of phosphorylated tau in the brains of patients with Alzheimer’s disease (AD), the pathogenesis of AD is also thought to involve mitochondrial dysfunctions and altered neurotransmission ...
Kan Yin Wong +5 more
semanticscholar +1 more source