The European Zoological Journal, 2017 Hibernation is an amazing animal strategy to survive when the environmental temperature is very low and food resources are scarce. Successful hibernation requires a variety of complex biological adaptations, in which the brain plays a central regulatory ...
E. Roda +4 more
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Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures [PDF]
, 2019 The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-aminobutyric acid type A receptors (GABAARs) at the appropriate synaptic sites.
Andrews, Peter M. +11 more
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Neurexin directs partner-specific synaptic connectivity in C. elegans
eLife, 2018 In neural circuits, individual neurons often make projections onto multiple postsynaptic partners. Here, we investigate molecular mechanisms by which these divergent connections are generated, using dyadic synapses in C. elegans as a model.
Alison Philbrook +7 more
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Frontiers in Cellular Neuroscience, 2021 Neurotransmitter dynamics within neuronal synapses can be controlled by astrocytes and reflect key contributors to neuronal activity. In particular, Glutamate (Glu) released by activated neurons is predominantly removed from the synaptic space by ...
Bronac Flanagan +5 more
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Optical modulation of neurotransmission using calcium photocurrents through the ion channel LiGluR
Frontiers in Molecular Neuroscience, 2013 A wide range of light-activated molecules (photoswitches and phototriggers) have been used to the study of computational properties of an isolated neuron by acting pre and postsynaptically.
Mercè eIzquierdo-Serra +5 more
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Presynaptic Autophagy and the Connection With Neurotransmission
Frontiers in Cell and Developmental Biology, 2021 Autophagy is an evolutionary conserved catabolic pathway essential for the maintenance of cellular homeostasis. Defective proteins and organelles are engulfed by autophagosomal membranes which fuse with lysosomes for cargo degradation.
Marianna Decet +3 more
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Organic Cation Transporter 3 (OCT3) Is Localized to Intracellular and Surface Membranes in Select Glial and Neuronal Cells Within the Basolateral Amygdaloid Complex of Both Rats and Mice [PDF]
, 2016 Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin. OCT3 is expressed widely throughout the
Chan, June +3 more
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Activity-dependent modulation of neural circuit synaptic connectivity
Frontiers in Molecular Neuroscience, 2009 In many nervous systems, the establishment of neural circuits is known to proceed via a two-stage process; 1) early, activity-independent wiring to produce a rough map characterized by excessive synaptic connections, and 2) subsequent, use-dependent
Charles R Tessier, Kendal Broadie
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Involvement of Noradrenergic Neurotransmission in the Stress- but not Cocaine-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Role for β-2 Adrenergic Receptors [PDF]
, 2010 The responsiveness of central noradrenergic systems to stressors and cocaine poses norepinephrine as a potential common mechanism through which drug re-exposure and stressful stimuli promote relapse.
A Dzung Lê +86 more
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Glycolysis-Derived Compounds From Astrocytes That Modulate Synaptic Communication
Frontiers in Neuroscience, 2019 Based on the concept of the tripartite synapse, we have reviewed the role of glucose-derived compounds in glycolytic pathways in astroglial cells.
Carlos-Alberto Gonçalves +7 more
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