Deciphering the skeletal interoceptive circuitry to control bone homeostasis
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu+7 more
wiley +1 more source
Genetic and molecular basis of abnormal BOLD signaling variability in patients with major depressive disorder after electroconvulsive therapy. [PDF]
Fan S+12 more
europepmc +1 more source
ABSTRACT This study explores the potential of Thymus ciliatus as a natural source of bioactive compounds by investigating its chemical composition and in vitro biological activities, including antioxidant, antimicrobial, antidiabetic, and anti‐Alzheimer properties.
Nadia Djermane+8 more
wiley +1 more source
Dietary <i>verbena officinalis</i> reduces feather-pecking duration in laying ducks by modulating cecal microbiota composition and hypothalamic neurotransmitter secretion. [PDF]
Liu A+5 more
europepmc +1 more source
Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition
ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi+7 more
wiley +1 more source
Disturbance of neurotransmitter metabolites in peripheral blood of schizophrenia patients treated with olanzapine: a preliminary targeted metabolomic study. [PDF]
Yin J, Gan Y, Jiang C, Wang J, Zhou Z.
europepmc +1 more source
ABSTRACT Benzodiazepines are widely used in the treatment of anxiety, but their use may be interrupted due to side effects. This study evaluated the indole alkaloids isocarapanaubine (indole alkaloid 1 [AIN1]) and 18‐β‐hydroxy‐3‐epi‐α‐yohimbine (indole alkaloid 2 [AIN2]), extracted from Rauvolfia ligustrina, in adult zebrafish.
Nádia Aguiar Portela Pinheiro+10 more
wiley +1 more source
Unraveling the Interplay Between Metabolism and Neurodevelopment in Health and Disease. [PDF]
He Y, Xie K, Yang K, Wang N, Zhang L.
europepmc +1 more source
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves+3 more
wiley +1 more source
Obesity-related alterations of intrinsic functional architecture: a resting-state fMRI study based on the human connectome project. [PDF]
Wang T+6 more
europepmc +1 more source