Results 321 to 330 of about 472,869 (430)

Senkyunolide I Improves Septicemia‐Induced Brain Dysfunction via Regulating Nrf2 and Astrocyte Activity.

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Senkyunolide I (Sen I) has a protective effect on the blood–brain barrier (BBB) in rats with sepsis‐associated encephalopathy (SAE). This study investigated whether Sen I regulates Nrf2 to ameliorate sepsis‐induced brain dysfunction (SIBD). Sixty rats were randomly assigned into Sham group, SAE group (Model group), SAE + Sen I group (72 mg/kg,
Haohao Cao, Tao Liu, Meixia Xu
wiley   +1 more source

A comparative exploration of monoamine neurotransmitter transport disorders: mechanisms, clinical manifestations, and therapeutic approaches. [PDF]

J Med Life
Al Sari RR, Thalib HI, Imad SS, Khan S, Haidar S, Al Zoabi BMK, Fadda SH, Fuadah S, Alwan HA, Alghobaishi A.   +9 more
europepmc   +1 more source

Is Aspartate an Excitatory Neurotransmitter?

Journal of Neuroscience, 2015
B. Herring, Katlin Silm, R. Edwards, R. Nicoll   +3 more
semanticscholar   +1 more source

Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects millions of individuals worldwide. Treatment strategies for AD vary depending on cognitive and behavioral symptoms, with cholinergic replacement therapy using acetylcholinesterase (AChE) inhibitors being one of the primary approaches.
Cansu Öztürk, Neslihan Balci, Osman Nuri Aslan, Erbay Kalay   +3 more
wiley   +1 more source

Disrupted intersubject variability architecture in structural and functional brain connectomes in major depressive disorder. [PDF]

Psychol Med
Fang K, Wen B, Liu L, Han S, Zhang W.
europepmc   +1 more source

Evidence for taurine as an inhibitory neurotransmitter in cerebellar stellate interneurons: selective antagonism by TAG (6-aminomethyl-3-methyl-4H,1,2,4-benzothiadiazine-1,1 -dioxide)

, 1983
Koichi Okamoto, Yutaka Sakai, Hideo Kimura   +2 more
openalex   +1 more source

Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala

Proceedings of the National Academy of Sciences of the United States of America, 2014
Jianyang Du, Leah R Reznikov, M. Price, Xiang-ming Zha, Yuan Lu, T. Moninger, J. Wemmie, M. Welsh   +7 more
semanticscholar   +1 more source

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia, Brahim Achour, Zubida M. Al‐Majdoub, Amin Rostami‐Hodjegan, Jill Barber   +4 more
wiley   +1 more source

<i>Lactiplantibacillus plantarum</i> GOLDGUT-HNU082 Alleviates CUMS-Induced Depressive-like Behaviors in Mice by Modulating the Gut Microbiota and Neurotransmitter Levels. [PDF]

Foods
Li W, Xu M, Liu Y, Zhang S, Wang J, Zhang Z, Xiao G, Wang R, Zhang J, Xue H.   +9 more
europepmc   +1 more source

Trends in gabapentinoid prescribing: A nationwide Danish drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Aims Pregabalin and gabapentin are increasingly used for pain and other conditions. Concerns exist about overuse as well as potential misuse and abuse. To guide rational prescribing practices, we provide detailed nationwide data on the use of gabapentinoids in Denmark.
Anton Pottegård, Lotte Rasmussen, Morten Olesen, Anne Mette Skov Sørensen, Zandra Nymand Ennis, Joseph Kane, Sarah Baxter, Blánaid Hicks   +7 more
wiley   +1 more source