Results 71 to 80 of about 470,740 (429)

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

The specification of glycinergic neurons and the role of glycinergic transmission in development

Frontiers in Molecular Neuroscience, 2010
Glycine’s role as an inhibitory neurotransmitter in the adult vertebrate nervous system has been well characterized in a number of different model organisms.
Alexander V Chalphin, Margaret S Saha
doaj   +1 more source

d-Amino Acids and Classical Neurotransmitters in Healthy and Type 2 Diabetes-Affected Human Pancreatic Islets of Langerhans

Metabolites, 2022
The pancreatic islets of Langerhans are clusters of cells that function as endocrine units synthesizing and releasing insulin and a range of additional peptide hormones.
Cindy J. Lee, Jack H. Schnieders, Stanislav S. Rubakhin, Amit V. Patel, Chengyang Liu, Ali Naji, Jonathan V. Sweedler   +6 more
doaj   +1 more source

Estimating the synaptic current in a multi-conductance AMPA receptor model [PDF]

, 2010
A pre-synaptic neuron releases diffusing neurotransmitters such as glutamate that activate post-synaptic receptors. The amplitude of the post-synaptic current, mostly mediated by glutamatergic (AMPARs) receptors, is a fundamental signal that may generate an action potential.
arxiv   +1 more source

Cortical Excitability Before and After Long‐Term Perampanel Treatment for Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Antiseizure medications (ASMs), which may influence cortical excitability, are the mainstay of epilepsy treatment. Transcranial magnetic stimulation (TMS) helps evaluate cortical excitability. We assessed changes in TMS responses using serial TMS measurements in people treated with an adjunctive noncompetitive AMPA‐receptor ...
Robert M. Helling, Johannes P. van Dijk, Prisca R. Bauer, Roland D. Thijs, Josemir W. Sander, Machiel Zwarts, Gerhard H. Visser   +6 more
wiley   +1 more source

Reducing excitoxicity with glutamate transporter-1 to treat stroke

Brain Circulation, 2016
The neurotransmitter glutamate is released following ischemic brain damage, and its excitotoxic effects contribute greatly to the development of stroke. Because this release of glutamate occurs within minutes, therapeutic drugs targeting the restriction ...
Yun Wang, Brandon K Harvey
doaj   +1 more source

Exogenous melatonin confers cold tolerance in rapeseed (Brassica napus L.) seedlings by improving antioxidants and genes expression

Plant Signaling & Behavior, 2022
Rapeseed (Brassica napus L.) is an important oilseed crop globally. However, its growth and production are significantly influenced by cold stress. To reveal the protective role of exogenous melatonin (MEL) in cold tolerance, rapeseed seedlings were ...
Yan Lei, Huang He, Ali Raza, Zeng Liu, Ding Xiaoyu, Wang Guijuan, Lv Yan, Cheng Yong, Zou Xiling   +8 more
doaj   +1 more source

Tryptophan and Cortisol Modulate the Kynurenine and Serotonin Transcriptional Pathway in the Kidney of Oncorhynchus kisutch

Animals, 2023
Aquaculture fish are kept for long periods in sea cages or tanks. Consequently, accumulated stress causes the fish to present serious problems with critical economic losses.
Luis Vargas-Chacoff, Daniela Nualart, Carolina Vargas-Lagos, Francisco Dann, José Luis Muñoz, Juan Pablo Pontigo   +5 more
doaj   +1 more source

Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release [PDF]

, 2020
Release of neurotransmitters relies on submillisecond coupling of synaptic vesicle fusion to the triggering signal: AP-evoked presynaptic Ca2+ influx.
Bello, Oscar D., Coleman, Jeff, Kotzadimitriou, Dimitrios, Krishnakumar, Shyam S., Mendonça, Philipe R. F., Nicholson, Elizabeth, Rothman, James E., Tagliatti, Erica, Timofeeva, Yulia, Volynski, Kirill E.   +9 more
core   +3 more sources

Na+/K+-pump and neurotransmitter membrane receptors

Invertebrate Neuroscience, 2018
Na+/K+-pump is an electrogenic transmembrane ATPase located in the outer plasma membrane of cells. The Na+/K+-ATPase pumps 3 sodium ions out of cells while pumping 2 potassium ions into cells. Both cations move against their concentration gradients. This
A. S. Pivovarov, F. Calahorro, R. Walker
semanticscholar   +1 more source