Results 161 to 170 of about 3,321,798 (216)

Using the neurotransmitter serotonin to target imaging agents to glioblastoma cells

Investigational New Drugs, 2012
The neurotransmitter serotonin is involved in numerous bodily functions via seven different serotonin receptor subfamilies. Serotonin plays a role in gastrointestinal functions like intestinal secretion or peristalsis and neuropsychiatric events like depression or migraine.
Sturzu, Alexander, Sheikh, Sumbla, Klose, Uwe, Echner, Hartmut, Kalbacher, Hubert, Deeg, Martin, Horger, Marius, Ernemann, Ulrike, Heckl, Stefan, Nägele, Thomas   +9 more
openaire   +4 more sources

A catecholamine neurotransmitter: epinephrine as a CO₂ wet scrubbing agent

Chemical Communications, 2019
Adrenaline can be used to capture CO2 when dissolved in DMSO.
Ala'a F. Eftaiha, Farah M. Mustafa, Fatima Alsoubani, Khaleel I. Assaf, Abdussalam K. Qaroush   +4 more
openaire   +3 more sources

Effect of antidepressant agents on β-adrenergic receptor and neurotransmitter regulatory systems

Pharmacology Biochemistry and Behavior, 1980
Abstract The effects of established and several novel antidepressant agents on brain monoamine oxidase A and B; high affinity synaptosomal uptake of norepinephrine, dopamine and serotonin; and β-adrenergic receptor kinetics evaluated by (3H)-dihydroalprenolol binding to cortical membranes are described.
Laurence R. Meyerson, Lawrence L. Martin, Helen H. Ong, Daniel B. Ellis   +3 more
openaire   +3 more sources

The GABA Paradox

Journal of Neurochemistry, 1999
Abstract : GABA, which is present in the brain in large amounts, is distributed among distinctly different cellular pools, possibly reflecting its multiple functions as metabolite, neurotransmitter, and neurotrophin. Its metabolic enzymes also exhibit heterogeneity, because glutamate decarboxylase exists in two isoforms with different subcellular ...
Helle S. Waagepetersen, Arne Schousboe, Ursula Sonnewald   +2 more
openaire   +3 more sources

Mesoporous, anisotropic nanostructures from bioinspired polymeric catecholamine neurotransmitters and their potential application as photoacoustic imaging agents

Journal of Materials Chemistry B, 2022
Different process parameters can be used to fabricate polydopamine, polynorepinephrine, and polyepinephrine nanospheres and mesoporous nanomaterials (golf balls and bowls) with structure-dependent performance as photoacoustic imaging agents.
Zhenzhen Lu, Shahinur Acter, Boon Mian Teo, Alexis I. Bishop, Rico F. Tabor, Mark Louis P. Vidallon   +5 more
openaire   +2 more sources

A validated LC-MS/MS method for neurotransmitter metabolite analysis in human cerebrospinal fluid using benzoyl chloride derivatization.

Bioanalysis, 2015
BACKGROUND Human cerebrospinal fluid (CSF) is often acquired in Phase I clinical trials to assess the CNS penetration of new pharmacological agents and to search for biomarkers associated with PD effects.
J. Cox, J. P. Butler, B. Lutzke, Barry Jones, John E. Buckholz, Raymond F. Biondolillo, Jayne A. Talbot, E. Chernet, K. Svensson, B. Ackermann   +9 more
semanticscholar   +1 more source

Neurotransmitter Interactions and Responsivity to Cholinomimetic Agents

1992
There is now overwhelming evidence for the involvement of forebrain cholinergic systems in Alzheimer’s disease and the cognitive processes that subserve learning and memory (Perry et al., 1978; Bigl et al., 1987; Koshimura et al., 1987; Doucette et al., 1986; Ichimiya et al., 1986; Saper et al., 1985;Whitehouse, 1986; McGeer et al., 1984; Mann et al ...
K. L. Davis, V. Haroutunian, A. C. Santucci   +2 more
openaire   +2 more sources

Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents.

Accounts of Chemical Research, 2012
Since the September 11, 2001, terrorist attacks in the United States, the specter of a chemical threat against civilian populations has renewed research interest in chemical warfare agents, their mechanisms of action, and treatments that reverse their ...
Guillaume Mercey, T. Verdelet, J. Renou, M. Kliachyna, R. Baati, F. Nachon, L. Jean, P. Renard   +7 more
semanticscholar   +1 more source

Modifications by Superoxide-Generating Agent, Neurotransmitters and Neuromodulators of Nitroxidergic Nerve Function in Monkey Cerebral Arteries

The Journal of Pharmacology and Experimental Therapeutics, 1998
Isolated monkey cerebral arteries denuded of the endothelium responded to transmural electrical stimulation (5 Hz for 40 sec) with relaxations that are mediated by nitric oxide (NO) synthesized from L-arginine. The relaxant response was slightly inhibited by duroquinone, a superoxide anion-generating agent.
T, Okamura, H, Fujioka, K, Ayajiki, N, Toda   +3 more
openaire   +2 more sources

Role of NO production in NMDA receptor-mediated neurotransmitter release in cerebral cortex.

Science, 1994
L-Glutamate and norepinephrine are examples of a major excitatory neurotransmitter and a neuromodulator in the cerebral cortex, respectively. Little is known of how chemical signaling between the anatomically distinct chemical pathways occurs.
PR Montague, CD Gancayco, MJ Winn, R. Marchase, M. Friedlander   +4 more
semanticscholar   +1 more source