Results 31 to 40 of about 3,535,923 (362)

Nitric oxide and synaptic function [PDF]

open access: yes, 1994
The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems.
Madison, Daniel V., Schuman, Erin M.
core   +1 more source

Mechanism of lily bulb and Rehmannia decoction in the treatment of lipopolysaccharide-induced depression-like rats based on metabolomics study and network pharmacology

open access: yesPharmaceutical Biology, 2022
Context Lily bulb and Rehmannia decoction (LBRD), consisting of Lilium henryi Baker (Liliaceae) and Rehmannia glutinosa (Gaertn) DC (Plantaginaceae), is a specialized traditional Chinese medicine formula for treating depression.
Xiansu Chi   +8 more
doaj   +1 more source

Blood platelet research in autism spectrum disorders: In search of biomarkers

open access: yesResearch and Practice in Thrombosis and Haemostasis, 2019
Autism spectrum disorder (ASD) is a clinically heterogeneous neurodevelopmental disorder that is caused by gene‐environment interactions. To improve its diagnosis and treatment, numerous efforts have been undertaken to identify reliable biomarkers for ...
Manisha Padmakumar   +3 more
doaj   +1 more source

Local and global spontaneous calcium events regulate neurite outgrowth and onset of GABAergic phenotype during neural precursor differentiation [PDF]

open access: yes, 2003
Neural stem cells can generate in vitro progenitors of the three main cell lineages found in the CNS. The signaling pathways underlying the acquisition of differentiated phenotypes in these cells are poorly understood.
Berridge, Michael J.   +5 more
core   +1 more source

Prototype chemical synapse chip for spatially patterned neurotransmitter stimulation of the retina ex vivo

open access: yesMicrosystems & Nanoengineering, 2017
Biomimetic stimulation of the retina with neurotransmitters, the natural agents of communication at chemical synapses, could be more effective than electrical stimulation for treating blindness from photoreceptor degenerative diseases.
Corey M. Rountree   +3 more
semanticscholar   +1 more source

Plants-Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms

open access: yesEvidence-Based Complementary and Alternative Medicine, 2017
Neuroprotection is the preservation of the structure and function of neurons from insults arising from cellular injuries induced by a variety of agents or neurodegenerative diseases (NDs).
T. Elufioye   +2 more
semanticscholar   +1 more source

Neurochemical Modulating Effect of Boswellia serrata Roxb. ex Colebr: A Preclinical Research

open access: yesPharmaceutical and Biomedical Research, 2022
Background: Boswellia serrata has been known for many decades and mentioned in the ancient Ayurvedic texts. Many previous studies have demonstrated its role in depression and anxiety in animal models.
Prabhakar Adake   +2 more
doaj  

Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders

open access: yesBehavioral Sciences, 2014
Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to modulate, dopaminergic and other neurotransmitter systems involved in the pathophysiology of various mental disorders.
Mona M Boules   +3 more
doaj   +1 more source

Fluoxetine: a case history of its discovery and preclinical development [PDF]

open access: yes, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N   +20 more
core   +2 more sources

Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents

open access: yesScientifica, 2018
Flavonoids are phenolic compounds found commonly in plants that protect them against the negative effects of environmental insults. These secondary metabolites have been widely studied in preclinical research because of their biological effects ...
León Jesús Germán-Ponciano   +3 more
semanticscholar   +1 more source

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