Results 31 to 40 of about 3,321,798 (216)

Blood platelet research in autism spectrum disorders: In search of biomarkers

Research and Practice in Thrombosis and Haemostasis, 2019
Autism spectrum disorder (ASD) is a clinically heterogeneous neurodevelopmental disorder that is caused by gene‐environment interactions. To improve its diagnosis and treatment, numerous efforts have been undertaken to identify reliable biomarkers for ...
Manisha Padmakumar, Eveline Van Raes, Chris Van Geet, Kathleen Freson   +3 more
doaj   +1 more source

Mechanism of lily bulb and Rehmannia decoction in the treatment of lipopolysaccharide-induced depression-like rats based on metabolomics study and network pharmacology

Pharmaceutical Biology, 2022
Context Lily bulb and Rehmannia decoction (LBRD), consisting of Lilium henryi Baker (Liliaceae) and Rehmannia glutinosa (Gaertn) DC (Plantaginaceae), is a specialized traditional Chinese medicine formula for treating depression.
Xiansu Chi, Xiaoyan Xue, Jin Pan, Jiang Wu, Huishan Shi, Yong Wang, Yanting Lu, Zhe Zhang, Ke Ma   +8 more
doaj   +1 more source

Plants-Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms

Evidence-Based Complementary and Alternative Medicine, 2017
Neuroprotection is the preservation of the structure and function of neurons from insults arising from cellular injuries induced by a variety of agents or neurodegenerative diseases (NDs).
T. Elufioye, Tomayo I. Berida, S. Habtemariam   +2 more
semanticscholar   +1 more source

Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases

Antioxidants, 2021
Neurotransmitter depletion and mitochondrial dysfunction are among the multiple pathological events that lead to neurodegeneration. Following our previous studies related with the development of multitarget mitochondriotropic antioxidants, this study ...
Daniel Chavarria, Ophelie Da Silva, Sofia Benfeito, Sandra Barreiro, Jorge Garrido, Fernando Cagide, Pedro Soares, Fernando Remião, Xavier Brazzolotto, Florian Nachon, Paulo J. Oliveira, José Dias, Fernanda Borges   +12 more
doaj   +1 more source

Prototype chemical synapse chip for spatially patterned neurotransmitter stimulation of the retina ex vivo

Microsystems & Nanoengineering, 2017
Biomimetic stimulation of the retina with neurotransmitters, the natural agents of communication at chemical synapses, could be more effective than electrical stimulation for treating blindness from photoreceptor degenerative diseases.
Corey M. Rountree, A. Raghunathan, J. Troy, L. Saggere   +3 more
semanticscholar   +1 more source

Neurochemical Modulating Effect of Boswellia serrata Roxb. ex Colebr: A Preclinical Research

Pharmaceutical and Biomedical Research, 2022
Background: Boswellia serrata has been known for many decades and mentioned in the ancient Ayurvedic texts. Many previous studies have demonstrated its role in depression and anxiety in animal models.
Prabhakar Adake, Mahalaxmi S Petimani, Greeshma B Kotian   +2 more
doaj  

Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders

Behavioral Sciences, 2014
Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to modulate, dopaminergic and other neurotransmitter systems involved in the pathophysiology of various mental disorders.
Mona M Boules, Paul Fredrickson, Amber M Muehlmann, Elliott Richelson   +3 more
doaj   +1 more source

Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents

Scientifica, 2018
Flavonoids are phenolic compounds found commonly in plants that protect them against the negative effects of environmental insults. These secondary metabolites have been widely studied in preclinical research because of their biological effects ...
León Jesús Germán-Ponciano, Gilberto Uriel Rosas-Sánchez, E. Rivadeneyra-Domínguez, J. Rodríguez-Landa   +3 more
semanticscholar   +1 more source

Deconstructed Analogues of Bupropion Reveal Structural Requirements for Transporter Inhibition versus Substrate-Induced Neurotransmitter Release.

ACS Chemical Neuroscience, 2017
Bupropion (1), an α-aminophenone uptake inhibitor at plasma membrane transporters for dopamine (DAT) and norepinephrine (NET), is a widely prescribed antidepressant and smoking cessation aid.
Abdelrahman R Shalabi, D. Walther, M. Baumann, R. Glennon   +3 more
semanticscholar   +1 more source

Pathophysiology, Therapeutic Targets, and Future Therapeutic Alternatives in COPD: Focus on the Importance of the Cholinergic System

Biomolecules, 2023
Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by airway limitation and changes in airway structure. It has a high global burden of mortality and morbidity.
Felisbela Gomes, Shih-Lung Cheng
doaj   +1 more source