Results 241 to 250 of about 169,266 (282)

Interaction between serotonin uptake inhibitors and alpha-2 adrenergic heteroreceptors in the rat hypothalamus.

Journal of Pharmacology and Experimental Therapeutics, 1990
The effectiveness of presynaptic receptor agonists to inhibit the electrically evoked release of [3H]monoamines from brain slices is attenuated in the presence of blockade of neuronal uptake for the serotonin (5-HT) and the norepinephrine (NE) systems ...
P. Blier, A. Galzin, Salomon Z. Langer
semanticscholar   +1 more source

Potency of Inhibitors for γ-Aminobutyric Acid Uptake by Mouse Brain Subcellular Particles at 0°

Molecular Pharmacology, 1975
Binding of γ-amino[14C]butyric acid by sucellular particles of mouse brain homogenates at 0° is apparently due to action of the specific transport system for GABA.
R. Olsen, J. Bayless, M. Ban
semanticscholar   +1 more source

CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS

2012
The present applications discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)-chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors. In other aspects the applications discloses the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
NEUROSEARCH AS, PETERS DAN, MUNRO GORDON, NIELSEN ELSEBET OESTERGAARD   +3 more
openaire   +1 more source

Trafficking-dependent and -independent pathways of neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase revealed in studies of insulin modulation of norepinephrine transport in SK-N-SH cells.

Journal of Pharmacology and Experimental Therapeutics, 2001
Presynaptic, cocaine- and antidepressant-sensitive norepinephrine (NE) transporters (NETs) dictate levels of extracellular NE after vesicular release. Recent studies suggest that G protein-coupled receptors linked to protein kinase C (PKC) down-regulate ...
S. Apparsundaram, U. Sung, Raymond D. Price, R. Blakely   +3 more
semanticscholar   +1 more source

A pharmacological review of competitive inhibitors and substrates of high-affinity, sodium-dependent glutamate transport in the central nervous system.

Current pharmaceutical design, 1999
The acidic amino acid L-glutamate acts as both a primary excitatory neurotransmitter and a potential neurotoxin within the mammalian central nervous system. Functionally juxtaposed between these neurophysiological and pathological actions are an assorted
R. Bridges, M. Kavanaugh, A. Chamberlin
semanticscholar   +1 more source

Mathematical model of dopamine autoreceptors and uptake inhibitors and their influence on tonic and phasic dopamine signaling.

Journal of Neurophysiology, 2013
J. Dreyer, J. Hounsgaard
semanticscholar   +1 more source

Synthesis and evaluation of N-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors.

Bioorganic & Medicinal Chemistry, 2013
G. Quandt, G. Höfner, K. Wanner
semanticscholar   +1 more source

Binding of [3H]-dopamine to human lymphocytes: possible relationship to neurotransmitter uptake sites.

Pharmacology, 1991
B. Faraj, Z. Olkowski, R. T. Jackson
semanticscholar   +1 more source

Common Anticonvulsants Inhibit Ca²⁺ Uptake and Amino Acid Neurotransmitter Release In Vitro

, 1987
J. M. Crowder, H. F. Bradford
openalex   +1 more source

Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3.

Journal of Medicinal Chemistry, 1994
T. G. M. Dhar, L. Borden, S. Tyagarajan, Kelli E. Smith, T. Branchek, R. Weinshank, C. Gluchowski   +6 more
semanticscholar   +1 more source