Results 151 to 160 of about 281,069 (321)

Systemic Administration of Neurotransmitter‐Derived Lipidoids‐PROTACs‐DNA Nanocomplex Promotes Tau Clearance and Cognitive Recovery for Alzheimer's Disease Therapy (Adv. Healthcare Mater. 32/2024) [PDF]

Baofeng Gong, Weicong Zhang, Wei Cong, Yuankai Gu, Wenbo Ji, Tong Yin, Honglei Zhou, Honggang Hu, Jianhua Zhuang, Yi Luo, Yan Liu, Jie Gao, You Yin   +12 more
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

LOCALIZATION OF PARVALBUMIN-EXPRESSING NEURONAL SYSTEMS IN THE CNS OF POLYPTERIFORM FISHES AND THEIR RELATIONSHIP TO OTHER NEUROTRANSMITTER SYSTEMS.

, 2023
Adrián Chinarro, Jesús M. López, Daniel Lozano, Sara Jiménez, Ruth Morona, Víctor Ruiz, Ana Martínez, Nerea Moreno   +7 more
openalex   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Empowering exhausted T cells of Glioblastoma patients by Neurotransmitters and Neuropeptides: decreasing immune checkpoint inhibitors, and increasing CD3zeta, proliferation and Glioblastoma arrest. [PDF]

Cancer Immunol Immunother
Levite M, Ilouz N, Galun E, Shoshan Y.
europepmc   +1 more source

Initial Distance‐Dependent Mean Force Drives Synaptic Vesicle Motion Toward Fusion Sites in Stimulated Hippocampal Neurons

Advanced Science, EarlyView.
Synaptic vesicle (SV) motion and exocytosis dynamics in the presynaptic terminals of live neurons are intimately linked to synaptic transmission during neuronal activity. In this work, it is revealed that, during electrical stimulation, SVs located farther from their fusion sites exhibit greater straightness and experience larger mean forces directed ...
Gyunam Park, Ji‐Hyun Kim, Hunki Lee, Chungwon Park, Sidong Chen, Luke Bates, Jaeyoung Sung, Hyokeun Park   +7 more
wiley   +1 more source

A pilot study of the plasma and urinary neurotransmitters in Chinese children with autism spectrum disorder. [PDF]

BMC Psychiatry
Xin Y, Yang Y, Qian Q, Xia T, Zhang W, Dai T, Li R, Liu Z, Zhang C.   +8 more
europepmc   +1 more source

Neurotransmitter‐related functional connectivity alterations associated with cognitive decline in people with mild cognitive impairment and mild Alzheimer’s disease [PDF]

Annalena Venneri, Riccardo Manca
openalex   +1 more source

Hungry for Knowledge: Octopamine Signaling Regulates Hunger‐Enhanced Olfactory Learning

Advanced Science, EarlyView.
Researchers demonstrate that hunger state facilitates both aversive and appetitive olfactory learning. Two distinct octopamine signaling pathways are involved in aversive or appetitive memory formation in the hunger state. And, hunger state also facilitates the formation of both types of memories via an evolutionarily conserved norepinephrine (the ...
Huijuan Zhao, Guiyuan Shi, Ruixue Qin, Yinghao Sun, Wenbo Guo, Ruixia Shi, Minxian Peng, Jingxuan Yang, Jianjian Zhao, Qiuhan Liu, Jun Xiao, Ke Zhang, Qiang Liu, Wenxing Yang, He Liu   +14 more
wiley   +1 more source

Norepinephrine Involvment in Penile Detumescence [PDF]

, 1990
Diederichs, W., Lue, Tom F., Stief, Christian Georg, Tanagho, Emil A.   +3 more
core   +1 more source