Results 91 to 100 of about 140,096 (282)

Examining changes in serum levels of Irisin and Brain-Derived Neurotrophic Factor in inactive middle-aged men in two phases of training and detraining [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām
Introduction:  Resistance training increases irisin and brain-derived neurotrophic factor secretion, impacting myogenic regulatory factors and muscle function, but maintaining these adaptations remains a challenging challenge.
Rezvan Afahar, Masoud Rahmati, Rahim Mirnasuri   +2 more
doaj  

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

Serum glial cell line-derived neurotrophic factor (GDNF) a potential biomarker of executive function in Parkinson’s disease [PDF]

, 2023
Shuyan Tong, Rui-Wen Wang, Qian Li, Yi Liu, Xiaoyan Yao, Deqin Geng, Dianshuai Gao, Chao Ren   +7 more
openalex   +1 more source

Iron Oxide Nanozyme as Reactive Oxygen and Nitrogen Species Scavenger to Regulate Microglial Homeostasis in Stroke

Advanced Science, EarlyView.
6 nm iron oxide nanoparticles (IONP6) exhibit enzyme‐like activities that scavenge reactive oxygen and nitrogen species (RONS), including nitric oxide (NO). In stroke models, IONP6 promotes microglial polarization toward the M2 phenotype, reduces neuroinflammation, and improves neurological outcomes, offering a promising drug‐free approach to mitigate ...
Yilin Qi, Chunxiao Wang, Yuqing Miao, Jiamin Li, Zengyu Xun, Di Sun, Fei Xu, Minrui Liu, Heping Wang, Galong Li, Xuyi Chen, Haiming Fan, Xue Xue   +12 more
wiley   +1 more source

A Biomimetic Norepinephrine‐Loaded Aligned Mineralized Collagen Scaffold for Coordinated Neurovascular, Osteogenic, and Immunomodulatory Repair of Critical‐Sized Bone Defects

Advanced Science, EarlyView.
Inspired by the composition and structure of native bone tissue and its complex interplay of biological signals, a norepinephrine‐loaded biomimetic mineralized electrocompacted collagen scaffold (NE‐MEC) is developed capable of simultaneously supporting osteogenesis, neural repair, angiogenesis, and immune modulation.
Zhengyun Ren, Zhaojun Wu, Anhang Wu, Hui Zhang, Jiachen Lu, Jiahao Zhang, Jie Weng, Jinhua Zhang, Song Chen, Huan Tan, Tailin Guo   +10 more
wiley   +1 more source

A painless nerve growth factor variant uncouples nociceptive and neurotrophic TrkA signaling [PDF]

Shailesh Kumar, Harry Jung, Gerard Walker, Jaimin K Rana, Rui Fu, Hong Minh Triet, Francesca Malerba, Jyotsna Kumar, Vikas Navratna, Wonhyeuk Jung, Sean Miller, Lukas M. Kruckenhauser, Simona Capsoni, Brian P. Hafler, Antonino Cattaneo, Yamuna Krishnan, Shyamal Mosalaganti, Moitrayee Bhattacharyya   +17 more
openalex   +1 more source

Advancing the Tendinopathy Triad: Comment on “Tendinopathy: The Interplay Between Mechanical Stress, Inflammation, and Vascularity”

Advanced Science, EarlyView.
Abstract Building upon the integrative framework of tendinopathy proposed by Gehwolf et al.—which elegantly connects mechanical stress, inflammation, and vascularity—this commentary extends the discussion by introducing novel mechanistic insights and future research directions that move beyond the established triad. A paradigm shift is proposed ...
DuJiang Yang, Jiexiang Yang, Shuang Wang, GuoYou Wang   +3 more
wiley   +1 more source

Anxiolytic- and Antidepressant-Like Effects of Fish Oil-Enriched Diet in Brain-Derived Neurotrophic Factor Deficient Mice [PDF]

, 2018
Juliane Zemdegs, Quentin Rainer, Cindy P. Grossmann, Delphine Rousseau‐Ralliard, Alain Grynberg, Eliane Beraldi Ribeiro, Bruno P. Guiard   +6 more
openalex   +1 more source

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source

Psychiatric disorders and brain-derived neurotrophic factor test: A summary on clinical reports

Journal of the Scientific Society
Brain-derived neurotrophic factor is a neurotrophin that is related to canonical nerve growth factor (BDNF). The protein BDNF is produced by the human nervous system.
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit   +1 more
doaj   +1 more source