Results 201 to 210 of about 223,804 (293)

Minocycline and bone marrow–derived mononuclear cells as potential therapeutics for hereditary retinal degenerations

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To assess in Royal College of Surgeons (RCS) rats if the combination of two previously documented neuroprotective strategies: minocycline administration and bone marrow–derived mononuclear cells (BM‐MNCs) intravitreal transplantation, offers enhanced neuroprotection compared with each treatment alone.
Alba Videla‐Ristol   +6 more
wiley   +1 more source

Microglial reactivity and nodule formation are associated with Synaptodendritic damage in the brains of people with HIV‐1

open access: yesBrain Pathology, EarlyView.
Despite effective ART, neurocognitive impairment persists in people with HIV. Brains from PWH present exacerbated microgliosis and formation of microglial nodules that are actively engaged in neuronal phagocytosis, resulting in neuronal injury and dendritic loss.
Roberta S. Dos Reis   +12 more
wiley   +1 more source

Optic nerve sheath meningioma exhibits neural niche‐associated transcriptomic features and rare copy number variation‐linked evolution

open access: yesBrain Pathology, EarlyView.
Optic nerve sheath meningiomas are typically NF2‐intact with few copy number alterations and are generally clinically indolent. Rare aggressive recurrences are associated with progressive accumulation of copy number variations, including CDKN2A/B homozygous deletion, 1q gain, and 14q loss.
Daisuke Sato   +15 more
wiley   +1 more source

Glial Cell Line-derived Neurotrophic Factor and Retinoic Acid Synergy Unlocks Neurogenesis in Adult Myenteric Glia/Neural Progenitors. [PDF]

open access: yesCell Mol Gastroenterol Hepatol
Han CY   +11 more
europepmc   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

open access: yesBritish Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander   +5 more
wiley   +1 more source

Results from a Phase I Extension Study of Ciliary Neurotrophic Factor in Patients with Macular Telangiectasia Type 2. [PDF]

open access: yesOphthalmol Sci
Singerman LJ   +6 more
europepmc   +1 more source

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