Results 111 to 120 of about 12,648,804 (372)
The GDNF-GFRα1 complex promotes the development of hippocampal dendritic arbors and spines via NCAM [PDF]
, 2016 The formation of synaptic connections during nervous system development requires the precise control of dendrite growth and synapse formation. Although glial cell line-derived neurotrophic factor (GDNF) and its receptor GFRα1 are expressed in the ...
Alsina, Fernando Cruz +5 more
core +2 more sources
The neurotrophic factor concept: a reexamination [PDF]
The Journal of Neuroscience, 1993 The neurotrophic factor concept in its basic form envisages that innervated tissues produce a signal for the innervating neurons for the selective limitation of neuronal death occurring during development (Purves, 1986; Oppenheim, 1991). This concept arose several decades ago on the basis of the observation that experimental manipulation of the amount ...
openaire +3 more sources
Advanced Science, EarlyView.The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi +15 more
wiley +1 more source
The systemic environment: at the interface of aging and adult neurogenesis. [PDF]
, 2017 Aging results in impaired neurogenesis in the two neurogenic niches of the adult mammalian brain, the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle.
Smith, Lucas K +2 more
core +1 more source
Evidence-Based Complementary and Alternative Medicine, 2013 Neurotrophic factors are playing vital roles in survival, growth, and function of neurons. Regulation of neurotrophic factors in the brain has been considered as one of the targets in developing drug or therapy against neuronal disorders.
S. L. Xu +6 more
semanticscholar +1 more source
Brain-Derived Neurotrophic Factor and Diabetes
International Journal of Molecular Sciences, 2020 Diabetes and its chronic complications still represent a great clinical problem, despite improvements made in the diagnosis and treatment of the disease.
Olga Różańska +2 more
semanticscholar +1 more source
Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation
Advanced Science, EarlyView.LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao +9 more
wiley +1 more source
Advanced Science, EarlyView.Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo +7 more
wiley +1 more source
The effect of neurotrophic factors in multiple sclerosis treatment: A review
مجله دانشگاه علوم پزشکی گرگان, 2019 Multiple sclerosis (MS) is a chronic and multiphasic autoimmune disease which affecting the nervous system. Recently, neurotrophic factor secreting cells have been proposed as one of the best sources for cell therapy in MS disease. Therefore, this review
Nazem Ghasemi
doaj
NEUROTROPHIC EFFECTS OF ETIFOXINE
Неврология, нейропсихиатрия, психосоматика, 2016 Higher anxiety results in the decreased levels of various neurotrophic factors and enkephalins and in impaired production of proinflammatory cytokines. The anxiolytic etifoxine is used to treat anxiety states and adjustment disorders. Etifoxine modulates
I. Yu. Torshin +4 more
doaj +1 more source