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Science, 1985
In addition to nerve growth factor (NGF), many proteins present in soluble tissue extracts and in the extracellular matrix influence the survival and development of cultured neurons. The structure, synthesis, and mechanism of action of NGF as a neurotrophic factor are considered along with the experiments on the new putative trophic molecules.
H, Thoenen, D, Edgar
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In addition to nerve growth factor (NGF), many proteins present in soluble tissue extracts and in the extracellular matrix influence the survival and development of cultured neurons. The structure, synthesis, and mechanism of action of NGF as a neurotrophic factor are considered along with the experiments on the new putative trophic molecules.
H, Thoenen, D, Edgar
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Trends in Neurosciences, 1999
Publisher Summary This chapter discusses several classes of nervous system growth factors focusing on neurotrophic factors. In the peripheral nervous system (PNS), neurotrophic factors are survival factors for several classes of neurons. The availability of limited quantities of nerve growth factor (NGF) in a target-derived manner is essential for the
Gerta Vrbová +2 more
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Publisher Summary This chapter discusses several classes of nervous system growth factors focusing on neurotrophic factors. In the peripheral nervous system (PNS), neurotrophic factors are survival factors for several classes of neurons. The availability of limited quantities of nerve growth factor (NGF) in a target-derived manner is essential for the
Gerta Vrbová +2 more
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Neurotrophic factors and their receptors
Annals of Neurology, 1994Development of the nervous system depends on signals that instruct neurons when to divide, differentiate, survive, or die. There are now two known distinct classes of factors noted for their neurotrophic activities-the family of factors collectively known as the neurotrophins, and ciliary neurotrophic factor.
Ip, Nancy Yuk-Yu LIFS +1 more
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Neuroprotection mediated via neurotrophic factors and induction of neurotrophic factors
Brain Research Reviews, 1999Neurotrophins and other neurotrophic factors have been shown to support the survival and differentiation of many neuronal populations of the central and peripheral nervous system. Therefore, administering neurotrophic factors could represent an alternative strategy for the treatment of acute and chronic brain disorders.
Irina Semkova, Josef Krieglstein
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The Clinical Journal of Pain, 2000
Neurotrophic factors have been shown to play significant roles in the transmission of physiologic and pathologic pain. Nerve growth factor appears to be particularly important. It is crucial for the development of sympathetic and small fiber sensory neurons that serve as nociceptors. It stimulates the expression and release of neuropeptides involved in
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Neurotrophic factors have been shown to play significant roles in the transmission of physiologic and pathologic pain. Nerve growth factor appears to be particularly important. It is crucial for the development of sympathetic and small fiber sensory neurons that serve as nociceptors. It stimulates the expression and release of neuropeptides involved in
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PHARMACOLOGY OF NEUROTROPHIC FACTORS
Annual Review of Pharmacology and Toxicology, 1997▪ Abstract The field of neurotrophic factor pharmacology emerged during the past decade with the discovery that these proteins can counteract neuronal atrophy and death in the adult nervous system. These concepts are being tested in clinical trials. Therapeutic use of neurotrophic proteins seems practical for diseases of the peripheral nervous system
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Neurotrophic factors and status epilepticus
Epilepsia, 2018SummaryBecause of their strong effects on cell survival and on synaptic function, neurotrophic factors (NTFs) have been hypothesized to be involved in some aspects of status epilepticus (SE) and in its possible consequences. This hypothesis has been explored mainly for 2 NTFs, namely fibroblast growth factor 2 (FGF‐2) and brain‐derived neurotrophic ...
Michele Simonato, Michele Simonato
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PEDF: a multifaceted neurotrophic factor [PDF]
Nature Reviews Neuroscience, 2003 Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor that protects neurons in many regions of the central nervous system against insults such as glutamate excitotoxicity and oxidative damage. Since the crystal structure of PEDF was solved, its biological actions have begun to be mapped to specific structural ...
Colin J. Barnstable, Joyce Tombran-Tink
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