Characterization of a glial cell line persistently infected with borna disease virus (BDV): influence of neurotrophic factors on BDV protein and RNA expression [PDF]
, 1993 Kathryn M. Carbone +3 more
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PAR1 activation induces the release by Schwann cells of factors promoting cell survival and neuritogenesis [PDF]
, 2017 Protease-activated receptor 1 (PAR1) is a member of a family of four G-protein-coupled receptors which are activated by proteolytic cleavage of their N-terminal extracellular domain.
Artico, M. +7 more
core
Advanced Science, EarlyView.Glioblastoma (GBM) is an aggressive brain cancer that often recurs and resists chemotherapy. This study found that a chemical called PGE2 causes surrounding brain cells (neurons) to become over‐excited, which makes GBM cells resistant to treatment. Researchers developed a new drug, “Compound 11,” which can cross into the brain and effectively block ...
Chih‐Jie Shen +14 more
wiley +1 more source
Advanced Science, EarlyView.This study shows that diabetes damages sensory nerve fibers, especially CGRP‐positive ones, in the periodontium and disrupts autophagy in trigeminal ganglion neurons, affecting bone homeostasis by inhibiting type H vessel formation. To address this, CGRP@PVA/tsPBA hydrogels are developed to release CGRP in response to ROS, which binds to endothelial ...
Chaoning Zhan +7 more
wiley +1 more source
Diet transition to a high-fat diet for 3 weeks reduces brain omega-3-fatty acid levels, alters BDNF signaling and induces anxiety & depression-like behavior in adult rats [PDF]
, 2012 Background: The consumption of diets high in calories and low in nutrient value is becoming increasingly common in modern society, which can lead to metabolic disorders like diabetes and obesity, and potentially to psychiatric disorders.
Fernando Gomez-Pinilla +2 more
core +1 more source
Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity
Advanced Science, EarlyView.This review proposes a conceptual framework for understanding glioma intratumoral heterogeneity shaped by neuro‐cancer interactions: functional patterns and transcriptional states. Functional patterns manifest as three major neural‐like adaptations with spatial and potentially hierarchical relationships, including neurogliomal synapses, glioma networks,
Tong Wu +8 more
wiley +1 more source
Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy
Advanced Science, EarlyView.This review highlights the pivotal role of the nervous system in cancer progression, emphasizing how neural–tumor interactions—via synaptic signaling, neurotransmitters, and paracrine factors—reshape the tumor microenvironment. It introduces cancer neuroscience as an emerging field and proposes integrating advanced tools such as AI and optogenetics to ...
Mengyu Yuan +4 more
wiley +1 more source
Peripheral nerve regeneration and neurotrophic factors [PDF]
, 1999 Giorgio Terenghi
openalex +1 more source
Recent Developments in Nanoparticle‐Hydrogel Hybrid Materials for Controlled Release
Advanced Science, EarlyView.This review highlights recent advances in nanoparticle–hydrogel hybrid materials for controlled drug delivery. It explores diverse nanocarrier–hydrogel combinations, drug loading strategies, release mechanisms, and stimuli‐responsive behaviors. Emphasis is placed on the molecular interactions driving hybrid material performance, offering insights into ...
Yiping Fan +8 more
wiley +1 more source
The Physiologic Basis of Molecular Therapeutics for Peripheral Nerve Injury: A Primer
Journal of Hand Surgery Global OnlinePeripheral nerve injuries affect a significant number of patients who experience trauma affecting the hand and upper extremity. Improving unsatisfactory outcomes from repair of these injuries remains a clinical challenge despite advancements in ...
Marie C. Spezia, MSc +2 more
doaj +1 more source