Results 111 to 120 of about 53,997 (300)
Propofol Neurotoxicity Is Mediated by p75 Neurotrophin Receptor Activation
Anesthesiology, 2012 Background: Propofol exposure to neurons during synaptogenesis results in apoptosis, leading to cognitive dysfunction in adulthood. Previous work from our laboratory showed that isoflurane neurotoxicity occurs through p75 neurotrophin receptor (p75NTR ...
Matthew L. Pearn +8 more
semanticscholar +1 more source
The human colon: Evidence for degenerative changes during aging and the physiological consequences
Neurogastroenterology &Motility, EarlyView.Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley +1 more source
BiologyStress is an important risk factor for the onset of anxiety and depression. The ability to cope with stressful events varies among different subjects, probably depending on different genetic variants, sex and previous life experiences.
Fernando Antonio Costa Xavier +3 more
doaj +1 more source
Frontiers in Physiology, 2017 Brain-derived neurotrophic factor (BDNF) is a major orchestrator of exercise-induced brain plasticity and circulating (peripheral) BDNF may have central effects.
Jeremy J. Walsh +3 more
doaj +1 more source
Serum Biomarkers and Their Clinical Correlates in Traumatic Trigeminal Neuropathy: A Pilot Study
Oral Diseases, EarlyView.ABSTRACT Objectives This study aims to investigate the serum biomarker levels in patients with painful post‐traumatic trigeminal neuropathy (PPTTN) and explore the associations between these biomarkers and the clinical and psychological characteristics of the patients. Materials and Methods A total of 32 patients with PPTTN were included.
Hye‐Kyoung Kim +2 more
wiley +1 more source
Neurotrophin receptor genes are expressed in distinct patterns in developing dorsal root ganglia [PDF]
, 1993 Xiaojun Mu +3 more
openalex +1 more source
Journal of Experimental Medicine, 2012 The neurotrophin receptor TrkB is up-regulated on astrocytes in white matter lesions from multiple sclerosis patients, and mice lacking TrkB specifically in astrocytes are more resistant to experimental autoimmune encephalomyelitis–induced ...
E. Colombo +9 more
semanticscholar +1 more source
Neurotrophins and Psychiatric Disorders
, 2014 Increasing number of studies has during the last decade linked neurotrophic factors with the pathophysiology of neuropsychiatric disorders and with the mechanisms of action of drugs used for the treatment of these disorders. In particular, brain-derived neurotrophic factor BDNF and its receptor TrkB have been connected with the pathophysiology in mood ...
Eero Castrén, Eero Castrén
openaire +4 more sources
Experimental Physiology, EarlyView.Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti +6 more
wiley +1 more source
K‐252 Compounds: Modulators of Neurotrophin Signal Transduction [PDF]
, 1992 Beat Knüsel, Franz Hefti
openalex +1 more source