Results 121 to 130 of about 72,847 (330)
Frontiers in Molecular Neuroscience, 2018 The p75 neurotrophin receptor (p75NTR), also known as low-affinity nerve growth factor, belongs to the tumor necrosis factor family of receptors. p75NTR is widely expressed in the nervous system during the development, as well as, in the neural crest ...
Sabine Wislet +3 more
doaj +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
p75NTR Promotes Circadian‐Driven Mineralization During Tooth Development via CK2/PER2 Pathway
Cell Proliferation, EarlyView.The diagram illustrates how the circadian rhythm regulates the p75NTR‐CK2‐PER2 axis, driving rhythmic biomineralisation during tooth development. ABSTRACT Circadian rhythm is an essential biological process that synchronises physiological activities with environmental light/dark cycles.
Manzhu Zhao +8 more
wiley +1 more source
Synthesis and Cytotoxic Profile of a Diphtheria Toxin‐Neurotrophin‐4 Chimera [PDF]
, 1997 Alessandro Negro, Stephen D. Skaper
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Neurotrophin and Neurotrophin Receptors in Human Fetal Kidney
Developmental Biology, 1996 Vertebrate kidney development involves a series of complex interactions between the ureteric bud and undifferentiated mesenchyme resulting in the production of the nephron unit. These interactions are thought to be dependent on a variety of locally derived soluble factors, including peptide growth factors and their receptors.
Huber, L.Julie +2 more
openaire +2 more sources
Diabetic kidney disease, biomarkers, and finerenone
Diabetes, Obesity and Metabolism, EarlyView.Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
wiley +1 more source
The p75 Neurotrophin Receptor Activates Akt (Protein Kinase B) through a Phosphatidylinositol 3-Kinase-dependent Pathway [PDF]
, 2001 Philippe P. Roux +3 more
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Epilepsia, EarlyView.Abstract Objective Despite decades of development in anti‐seizure medications, ~30% of individuals remain refractory to all treatments, and none of the existing therapies are disease modifying. Identifying targets outside the current preclinical paradigm is critically important.
Giovanna L. Durante +4 more
wiley +1 more source
Modulation of Small RNA Signatures in Schwann-Cell-Derived Extracellular Vesicles by the p75 Neurotrophin Receptor and Sortilin [PDF]
, 2020 Nádia Pereira Gonçalves +7 more
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