Results 11 to 20 of about 38,974 (303)

Neurotrophins and Neurotrophin Receptors in Adult Brain Plasticity [PDF]

Neural Plasticity, 1992
Franz Hefti, Dalia M. Araujo, Klaus D. Beck, Jonathan Day, Caleb E. Finch, Beat Knüsel, Paul A. Lapchak, Thomas H. McNeill   +7 more
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Crystals of the neurotrophins [PDF]

Protein Science, 1996
AbstractThe neurotrophins show a high degree of amino acid sequence homology, share similar solution properties, and display distinct but parallel functionalities. Here we report the crystallization and preliminary X‐ray characterization of three neurotrophins: brain‐derived neurotrophin, neurotrophin 3, and the heterodimer between brain‐derived ...
Robinson, R, Radziejewski, C, Stuart, D, Jones, E   +3 more
openaire   +3 more sources

Neurotrophins [PDF]

Neuron, 2002
The family of neurotrophic factors known as neurotrophins has yielded a series of surprises, both with regard to the broad extent of their functional roles and the remarkable complexity of their signaling mechanisms. The recent discovery that a neurotrophin precursor protein and its proteolytically processed products may differentially activate pro ...
Moses V. Chao, Mark Bothwell
openaire   +3 more sources

The Molecular Effects of BDNF Synthesis on Skeletal Muscle: A Mini-Review

Frontiers in Physiology, 2022
The brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family which is generated mainly by the brain. Its main role involve synaptic modulation, neurogenesis, neuron survival, immune regulation, myocardial contraction, and ...
I. Rentería, P. C. García-Suárez, P. C. García-Suárez, A. C. Fry, J. Moncada-Jiménez, J. P. Machado-Parra, B. M. Antunes, A. Jiménez-Maldonado   +7 more
doaj   +1 more source

Local Effect of Neurotrophin-3 in Neuronal Inflammation of Allergic Rhinitis: Preliminary Report

Balkan Medical Journal, 2015
Background: Allergic rhinitis is a common inflammatory nasal mucosal disease characterized by sneezing, watery nasal discharge, nasal obstruction and itching.
Onur İsmi, Cengiz Özcan, Yusuf Vayisoğlu, Kemal Görür, Tuba Karabacak, Gürbüz Polat, Taylan Güçlütürk   +6 more
doaj   +1 more source

Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity

Biomedicines, 2022
Neurotrophins are growth factors that exert important neuroprotective effects by preventing neuronal death and synaptic loss. Nerve Growth Factor (NGF) acts through the activation of its high-affinity, pro-survival TrkA and low-affinity, pro-apoptotic ...
Thanasis Rogdakis, Despoina Charou, Alessia Latorrata, Eleni Papadimitriou, Alexandros Tsengenes, Christina Athanasiou, Marianna Papadopoulou, Constantina Chalikiopoulou, Theodora Katsila, Isbaal Ramos, Kyriakos C. Prousis, Rebecca C. Wade, Kyriaki Sidiropoulou, Theodora Calogeropoulou, Achille Gravanis, Ioannis Charalampopoulos   +15 more
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Sustained Neurotrophin Release from Protein Nanoparticles Mediated by Matrix Metalloproteinases Induces the Alignment and Differentiation of Nerve Cells

Biomolecules, 2019
The spatial and temporal availability of cytokines, and the microenvironments this creates, is critical to tissue development and homeostasis. Creating concentration gradients in vitro using soluble proteins is challenging as they do not provide a self ...
Yuka Matsuzaki, Rina Maruta, Keiko Takaki, Eiji Kotani, Yasuko Kato, Ryoichi Yoshimura, Yasuhisa Endo, Ciara Whitty, Christian Pernstich, Raj Gandhi, Michael Jones, Hajime Mori   +11 more
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Regulation of Endosomal Trafficking by Rab7 and Its Effectors in Neurons: Clues from Charcot–Marie–Tooth 2B Disease

Biomolecules, 2023
Intracellular endosomal trafficking controls the balance between protein degradation and synthesis, i.e., proteostasis, but also many of the cellular signaling pathways that emanate from activated growth factor receptors after endocytosis.
Ryan J. Mulligan, Bettina Winckler
doaj   +1 more source

Oxytocin/Osteocalcin/IL-6 and NGF/BDNF mRNA Levels in Response to Cold Stress Challenge in Mice: Possible Oxytonic Brain-Bone-Muscle-Interaction

Frontiers in Physiology, 2019
Oxytocin (Oxt), osteocalcin (Ost), and NGF/BDNF have a role in bone homeostasis, reproduction, and cognition. Oxt/Ost is required for muscle repair. We investigated gene response of muscle and the inter-organ communication following cold stress (CS). The
Claudia Camerino, Elena Conte, Maria Rosaria Carratù, Adriano Fonzino, Marcello Diego Lograno, Domenico Tricarico   +5 more
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The Toll Route to Structural Brain Plasticity

Frontiers in Physiology, 2021
The human brain can change throughout life as we learn, adapt and age. A balance between structural brain plasticity and homeostasis characterizes the healthy brain, and the breakdown of this balance accompanies brain tumors, psychiatric disorders, and ...
Guiyi Li, Alicia Hidalgo
doaj   +1 more source