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Neurotrophins and neurodegeneration
Neuropathology and Applied Neurobiology, 2003There is growing evidence that reduced neurotrophic support is a significant factor in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). In this review we discuss the structure and functions of neurotrophins such as nerve growth factor, and the role of ...
Dawbarn, D, Allen, SJ
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Functional Interactions of Neurotrophins and Neurotrophin Receptors
Annual Review of Neuroscience, 1995Hypothesis Programmed neuronal cell death is a prominent feature of vertebrate embryonic development. Timing and extent of cell death are dependent on the influence of the targets those neurons innervate, The number of neurons in the adult nervous system and the density of innervation of their targets are determined by a competitive process in which ...
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Neurotrophin and Neurotrophin Receptors in Islet Cells
Hormone and Metabolic Research, 1997A large number of proteins are found specifically in insulin-producing cells and in neuronal cells. The function of neurotrophins in beta cells and the molecular mechanism leading to their expression include the expression of functional receptors for different neurotrophins.
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Autonomic Neuroscience, 2010
The aim of this review is to report recent findings and ongoing studies on the effects of acupuncture on endogenous biological mediators, in particular on neurotrophins such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). Acupuncture is a therapeutic technique and is a part of Traditional Chinese Medicine (TCM).
Luigi Manni +4 more
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The aim of this review is to report recent findings and ongoing studies on the effects of acupuncture on endogenous biological mediators, in particular on neurotrophins such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). Acupuncture is a therapeutic technique and is a part of Traditional Chinese Medicine (TCM).
Luigi Manni +4 more
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2014
There is ample evidence suggesting that neurotrophins in particular nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) regulate pain processing as the modulators. NGF released from local tissue and dorsal root ganglia (DRG) binds to tropomyosin-related kinase (Trk) A receptors and regulates many membrane receptors, ion channels, and
Ru-Ping Dai, Xin-Fu Zhou
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There is ample evidence suggesting that neurotrophins in particular nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) regulate pain processing as the modulators. NGF released from local tissue and dorsal root ganglia (DRG) binds to tropomyosin-related kinase (Trk) A receptors and regulates many membrane receptors, ion channels, and
Ru-Ping Dai, Xin-Fu Zhou
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Physiology of the Neurotrophins
Annual Review of Neuroscience, 1996The neurotrophins are a small group of dimeric proteins that profoundly affect the development of the nervous system of vertebrates. Recent studies have established clear correlations between the survival requirements for different neurotrophins of functionally distinct subsets of sensory neurons.
Lewin, G. R., Barde, Y. A.
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2017
Neurotrophins (NTs) have been implicated in generation and modulation of nociceptive pathways. Change in NTs levels is associated with painful conditions and neurological diseases such as migraine. Currently, it is generally recognized that migraine headaches result from the activation and sensitization of trigeminal sensory afferent fibers leading to ...
L B, Martins +2 more
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Neurotrophins (NTs) have been implicated in generation and modulation of nociceptive pathways. Change in NTs levels is associated with painful conditions and neurological diseases such as migraine. Currently, it is generally recognized that migraine headaches result from the activation and sensitization of trigeminal sensory afferent fibers leading to ...
L B, Martins +2 more
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Trends in Pharmacological Sciences, 1999
Exogenous delivery of the neurotrophic factors, brain-derived neurotrophic factor (BDNF) or neurotrophin-3 (NT-3), promotes the function, sprouting and regrowth of 5-HT-containing neurones in the brains of adult rats. Similar infusions of BDNF into the dorsal raphe nucleus produce an antidepressant effect, as evaluated by several 'learned helplessness'
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Exogenous delivery of the neurotrophic factors, brain-derived neurotrophic factor (BDNF) or neurotrophin-3 (NT-3), promotes the function, sprouting and regrowth of 5-HT-containing neurones in the brains of adult rats. Similar infusions of BDNF into the dorsal raphe nucleus produce an antidepressant effect, as evaluated by several 'learned helplessness'
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Current Opinion in Neurobiology, 1994
The neurotrophins act through their signalling competent trk tyrosine kinase receptors (trkA, trkB and trkC), and, in addition, they share a common low-affinity receptor, p75. Acting alone, trk kinases can mediate neurotrophin action, including survival, fiber outgrowth, differentiation and proliferation.
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The neurotrophins act through their signalling competent trk tyrosine kinase receptors (trkA, trkB and trkC), and, in addition, they share a common low-affinity receptor, p75. Acting alone, trk kinases can mediate neurotrophin action, including survival, fiber outgrowth, differentiation and proliferation.
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Alterations in neurotrophins and neurotrophin receptors in Alzheimer’s disease
2000We demonstrated that nerve growth factor (NGF) levels were increased in hippocampus and cortical areas, as well as in cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD). Such increases may, at least in part, be due to a decreased expression of the NGF high affinity receptor trkA.
C H, Hock +6 more
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