Results 181 to 190 of about 47,357 (330)
AAV Assembled Capsids Are Produced in Cells Blocked From Cell Cycle Progression
Biotechnology and Bioengineering, Volume 123, Issue 2, Page 273-286, February 2026.ABSTRACT Adeno‐associated virus (AAV) is a promising delivery system for gene therapy. However, current manufacturing of AAV suffers from very low yields compared to other biotherapeutics. The AAV dose per patient ranges between 1011and 1015 viral genomes (vg), requiring an average of 10 to 30 L production/dose.
Alaka Mullick +8 more
wiley +1 more source
The Dark Side of the NGF Family: Neurotrophins in Neoplasias
, 2006 Alex Krüttgen +2 more
openalex +2 more sources
Expression of Neurotrophin-3 (NT-3) and Anterograde Axonal Transport of Endogenous NT-3 by Retinal Ganglion Cells in Chick Embryos [PDF]
, 2000 Christopher S. von Bartheld +1 more
openalex +1 more source
MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies
MedComm, Volume 7, Issue 2, February 2026.The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu +6 more
wiley +1 more source
Astrocyte Senescence Impairs Synaptogenesis due to Thrombospondin‐1 Loss
Aging Cell, Volume 25, Issue 2, February 2026.Senescent hippocampal astrocytes lose TSP secretion, impairing excitatory synaptogenesis via the α2δ‐1 pathway. Restoring TSP‐1 rescues synaptic formation, revealing the contribution of astrocyte senescence to age‐related hippocampal synaptic decline.
Stefano Ercoli +3 more
wiley +1 more source
Current State of the Neurotrophin-Based Pharmaceutics in the Treatment of Neurodegenerative Diseases and Neuroinflammation. [PDF]
Med Sci (Basel)Fedotcheva TA, Shimanovsky NL.
europepmc +1 more source
Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT To summarize the available evidence in the literature regarding the effects of exposure to an enriched environment (EE) on the modulation of apoptotic markers in central tissue of rodents under unfavorable conditions. Searches were conducted in three databases: PubMed/Medline (70 articles), Scopus (65 articles), and EMBASE (128 articles), all ...
Matheus Santos de Sousa Fernandes +7 more
wiley +1 more source
Expression of Neurotrophin Genes in the Hypothalamus of Stressed and Allopregnanolone-Infused Sheep. [PDF]
Int J Mol SciMłotkowska P +4 more
europepmc +1 more source