Results 31 to 40 of about 26,439 (246)

Alternative Pharmacological Strategies for the Treatment of Alzheimer’s Disease: Focus on Neuromodulator Function

Biomedicines, 2022
Alzheimer’s disease (AD) is a neurodegenerative disorder, comprising 70% of dementia diagnoses worldwide and affecting 1 in 9 people over the age of 65.
Grace Cunliffe, Yi Tang Lim, Woori Chae, Sangyong Jung   +3 more
doaj   +1 more source

Neurotrophins and B-cell malignancies

, 2016
Neurotrophins and their receptors act as important proliferative and pro-survival factors in a variety of cell types. Neurotrophins are produced by multiple cell types in both pro and mature forms, and can act in an autocrine or paracrine fashion.
Hillis, Jennifer, Michael O’Dwyer, Jennifer Hillis, O\u27Dwyer, Michael, Adrienne M. Gorman, Gorman, Adrienne   +5 more
core   +2 more sources

Proneurotrophin-3 promotes cell cycle withdrawal of developing cerebellar granule cell progenitors via the p75 neurotrophin receptor

eLife, 2016
Cerebellar granule cell progenitors (GCP) proliferate extensively in the external granule layer (EGL) of the developing cerebellum prior to differentiating and migrating.
Juan Pablo Zanin, Elizabeth Abercrombie, Wilma J Friedman   +2 more
doaj   +1 more source

Nerves in the Tumor Microenvironment: Origin and Effects

Frontiers in Cell and Developmental Biology, 2020
Studies have reported the vital role of nerves in tumorigenesis and cancer progression. Nerves infiltrate the tumor microenvironment thereby enhancing cancer growth and metastasis.
Wenjun Wang, Lingyu Li, Naifei Chen, Chao Niu, Zhi Li, Jifan Hu, Jifan Hu, Jiuwei Cui   +7 more
doaj   +1 more source

mTOR Signaling in BDNF-Treated Guinea Pigs after Ototoxic Deafening

Biomedicines, 2022
The mammalian target of rapamycin (mTOR) signaling plays a critical role in cell homeostasis, growth and survival. Here, we investigated the localization of the main mTOR signaling proteins in the organ of Corti of normal-hearing and deafened guinea pigs,
Annamaria Tisi, Dyan Ramekers, Vincenzo Flati, Huib Versnel, Rita Maccarone   +4 more
doaj   +1 more source

Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings [PDF]

Brazilian Journal of Psychiatry, 2020
Bipolar disorder (BD) is a chronic mental illness characterized by changes in mood that alternate between mania and hypomania or between depression and mixed states, often associated with functional impairment.
Giselli Scaini, Samira S. Valvassori, Alexandre P. Diaz, Camila N. Lima, Deborah Benevenuto, Gabriel R. Fries, Joao Quevedo   +6 more
doaj   +1 more source

Biomimetic Approaches for Separated Regeneration of Sensory and Motor Fibers in Amputee People: Necessary Conditions for Functional Integration of Sensory–Motor Prostheses With the Peripheral Nerves

Frontiers in Bioengineering and Biotechnology, 2020
The regenerative capacity of the peripheral nervous system after an injury is limited, and a complete function is not recovered, mainly due to the loss of nerve tissue after the injury that causes a separation between the nerve ends and to the ...
Atocha Guedan-Duran, Atocha Guedan-Duran, Atocha Guedan-Duran, Nahla Jemni-Damer, Nahla Jemni-Damer, Irune Orueta-Zenarruzabeitia, Irune Orueta-Zenarruzabeitia, Gustavo Víctor Guinea, Gustavo Víctor Guinea, Gustavo Víctor Guinea, Gustavo Víctor Guinea, José Perez-Rigueiro, José Perez-Rigueiro, José Perez-Rigueiro, José Perez-Rigueiro, Daniel Gonzalez-Nieto, Daniel Gonzalez-Nieto, Daniel Gonzalez-Nieto, Fivos Panetsos, Fivos Panetsos, Fivos Panetsos   +20 more
doaj   +1 more source

The Effects of Nordic Walking With Poles With an Integrated Resistance Shock Absorber on Cognitive Abilities and Cardiopulmonary Efficiency in Postmenopausal Women

Frontiers in Aging Neuroscience, 2020
Late adulthood is associated with atrophy of brain areas, which contribute to cognitive deterioration and increase the risk of depression. On the other hand, aerobic exercise can improve learning and memory function, ameliorate mood, and prevent ...
Katarzyna Domaszewska, Magdalena Koper, Krystian Wochna, Urszula Czerniak, Katarzyna Marciniak, Maciej Wilski, Dorota Bukowska   +6 more
doaj   +1 more source

Neurotrophins and Neurotrophin Receptors in Proliferative Diabetic Retinopathy

PLoS ONE, 2013
Neurotrophins (NTs) are emerging as important mediators of angiogenesis and fibrosis. We investigated the expression of the NTs nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) and their receptors TrkA, TrkB, and TrkC in proliferative diabetic retinopathy (PDR).
Abu El-Asrar, Ahmed M., Mohammad, Ghulam, De Hertogh, Gert, Nawaz, Mohd Imtiaz, Van Den Eynde, Kathleen, Siddiquei, Mohammad Mairaj, Struyf, Sofie, Opdenakker, Ghislain, Geboes, Karel   +8 more
openaire   +4 more sources

Long-Term Consequences of Developmental Alcohol Exposure on Brain Structure and Function: Therapeutic Benefits of Physical Activity

Brain Sciences, 2012
Developmental alcohol exposure both early in life and during adolescence can have a devastating impact on normal brain structure and functioning, leading to behavioral and cognitive impairments that persist throughout the lifespan.
Gillian F. Hamilton, Anna Y. Klintsova, Karen E. Boschen   +2 more
doaj   +1 more source