A Single Aplysia Neurotrophin Mediates Synaptic Facilitation via Differentially Processed Isoforms
Cell Reports, 2013 Neurotrophins control the development and adult plasticity of the vertebrate nervous system. Failure to identify invertebrate neurotrophin orthologs, however, has precluded studies in invertebrate models, limiting our understanding of fundamental aspects
Stefan R. Kassabov +5 more
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Nerve Growth Factor and Autoimmune Diseases
Current Issues in Molecular Biology, 2023 NGF plays a crucial immunomodulatory role and increased levels are found in numerous tissues during autoimmune states. NGF directly modulates innate and adaptive immune responses of B and T cells and causes the release of neuropeptides and ...
Sergio Terracina +10 more
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Mice with altered BDNF signaling as models for mood disorders and antidepressant effects
Frontiers in Behavioral Neuroscience, 2014 Brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase TrkB support neuronal survival during development and promote connectivity and plasticity in the adult brain.
Jesse Saku Olavi Lindholm +1 more
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Biomedicines, 2022 Alzheimer’s disease (AD) is a neurodegenerative disorder, comprising 70% of dementia diagnoses worldwide and affecting 1 in 9 people over the age of 65.
Grace Cunliffe +3 more
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Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]
, 2011 Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell +39 more
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eLife, 2016 Cerebellar granule cell progenitors (GCP) proliferate extensively in the external granule layer (EGL) of the developing cerebellum prior to differentiating and migrating.
Juan Pablo Zanin +2 more
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Nerves in the Tumor Microenvironment: Origin and Effects
Frontiers in Cell and Developmental Biology, 2020 Studies have reported the vital role of nerves in tumorigenesis and cancer progression. Nerves infiltrate the tumor microenvironment thereby enhancing cancer growth and metastasis.
Wenjun Wang +7 more
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mTOR Signaling in BDNF-Treated Guinea Pigs after Ototoxic Deafening
Biomedicines, 2022 The mammalian target of rapamycin (mTOR) signaling plays a critical role in cell homeostasis, growth and survival. Here, we investigated the localization of the main mTOR signaling proteins in the organ of Corti of normal-hearing and deafened guinea pigs,
Annamaria Tisi +4 more
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Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings [PDF]
Brazilian Journal of Psychiatry, 2020 Bipolar disorder (BD) is a chronic mental illness characterized by changes in mood that alternate between mania and hypomania or between depression and mixed states, often associated with functional impairment.
Giselli Scaini +6 more
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TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death [PDF]
, 1997 Newborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that trkB (¿/¿) mice have a significant
Alcántara Horrillo, Soledad +5 more
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