Results 91 to 100 of about 14,410 (259)

Ictal but not interictal epileptic discharges activate astrocyte endfeet and elicit cerebral arteriole responses.

Frontiers in Cellular Neuroscience, 2011
Activation of astrocytes by neuronal signals plays a central role in the control of neuronal activity-dependent blood flow changes in the normal brain.
Marta eGomez-Gonzalo, Gabriele eLosi, Marco eBrondi, Marco eBrondi, Marco eBrondi, Laura eUva, Sebastian eSulis-Sato, Sebastian eSulis-Sato, Sebastian eSulis-Sato, Marco eDe Curtis, Gian Michele eRatto, Giorgio eCarmignoto   +11 more
doaj   +1 more source

Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain

Epilepsia, EarlyView.
Abstract Objective Spreading depolarization (SD) is a phenomenon underlying various neurological conditions, including epilepsy. Researchers have suspected that local tissue oxygenation breakdown induces spontaneous SD. In this study, we investigated the relationship between spontaneous epileptic seizures and SD, with a focus on the role of local ...
Jiayang Liu, Bruce J. Gluckman
wiley   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

Outcomes and Innervation of Gracilis for Pediatric Facial Paralysis: A Systematic Review

The Laryngoscope, EarlyView.
This systematic review compares innervation techniques for gracilis free muscle transfer in pediatric facial paralysis. Masseteric innervation produced the greatest commissure excursion, cross‐facial nerve grafting enabled spontaneous smiles, and dual innervation balanced both with high satisfaction and low complication rates across techniques ...
Kaiwen Chen, Shaun A. Nguyen, Warren B. Chun, Charles M. Henry, Matthew H. Cheung, Cory Hyun‐su Kim, Michelle S. Hwang   +6 more
wiley   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

A time-synchronized multimodal monitoring system for general anesthesia

Medicine in Novel Technology and Devices
In clinical settings, different kinds of patient monitoring systems and depth of anesthesia monitoring (DoA) systems have been widely used to assess the depth of sedation and patient's state.
Zhenhu Liang, Guanwei Geng, Qifeng Song, Mengmeng Tang   +3 more
doaj   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Mathematical modeling of neurovascular coupling

, 2020
The brain is critically dependent on the continuous supply of oxygen and glucose, which is carried and delivered by blood.
openaire   +4 more sources

GBA1 Variants with Unknown Classification Are Modest Contributors to Parkinson's Disease Susceptibility

Movement Disorders, EarlyView.
Abstract Background GBA1 variants cause Gaucher's disease (GD) in biallelic forms and increase Parkinson's disease (PD) risk in heterozygous carriers. Carriers of mild or severe variants (causing GD type 1 or types 2–3) can enroll in clinical trials, whereas those with GBA1 variants classified as unknown are typically excluded.
Sitki Cem Parlar, Yoomin Lee, Ziv Gan‐Or   +2 more
wiley   +1 more source

Pallidal Evoked Resonant Neural Activity as a Candidate Biomarker for Deep Brain Stimulation in Dystonia

Movement Disorders, EarlyView.
Abstract Background Deep brain stimulation (DBS) targeted to the globus pallidus (GP) can effectively alleviate dystonia symptoms. However, identifying optimal therapeutic stimulation parameters is challenging due to the manual programming process and the paucity of acute effects of DBS on dystonia symptoms.
Kara A. Johnson, Patricia B. Coutinho, Filipe P. Sarmento, Elizabeth Vo, Joshua K. Wong, Justin D. Hilliard, Kelly D. Foote, Coralie de Hemptinne   +7 more
wiley   +1 more source