Results 91 to 100 of about 17,591 (285)

Neurovascular and Neurometabolic Derailment in Aging and Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2015
The functional and structural integrity of the brain requires local adjustment of blood flow and regulated delivery of metabolic substrates to meet the metabolic demands imposed by neuronal activation.
Cátia eLourenço, Ana eLedo, Cândida eDias, Rui M Barbosa, João eLaranjinha   +4 more
doaj   +1 more source

Neurovascular coupling in early stage dementia: a case-control study

, 2023
Cerebral amyloid angiopathy (CAA) is frequently found post mortem in Alzheimer’s dementia, but often undetected during life especially since in vivo hallmarks of CAA and its vascular damage become overt relatively late in the disease process.
Drenth, N., Blauw, G.J., Dijk, S.E. van, Rooden, S. van, Witjes-Ane, M.N.W., Grond, J. van der, Hafkemeijer, A., Labadie, G., Rombouts, S.A.   +8 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Is There a Persistent Dysfunction of Neurovascular Coupling in Migraine? [PDF]

BioMed Research International, 2015
Changes in cerebral blood flow are one of the main features of migraine attack and have inspired the vascular theory of migraine. This traditional view has been reshaped with recent experimental data, which gave rise to the neural theory of migraine. In this review, we speculate that there might be an important link between the two theories, that is ...
Andrej Fabjan, Marjan Zaletel, Bojana Žvan   +2 more
openaire   +2 more sources

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Insulin regulates neurovascular coupling through astrocytes.

, 2022
Mice with insulin receptor (IR)-deficient astrocytes (GFAP-IR knockout [KO] mice) show blunted responses to insulin and reduced brain glucose uptake, whereas IR-deficient astrocytes show disturbed mitochondrial responses to glucose.
Iglesias, T., Gutierrez, A., García-Cáceres, C., Torres Aleman, I., Tschöp, M.H., Navarrete, M., Palenzuela, R., Mostany, R., Pose-Utrilla, J., Pignatelli, J., Davila, J.C., Viedma-Moreno, E., Fernandez, A.M., Guerra-Cantera, S., de Ceballos, M.L., Martinez-Rachadell, L., Diaz-Pacheco, S., Ruiz de Martin Esteban, S.   +17 more
core   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

The neurovascular basis of processing speed differences in humans: A model-systems approach using multiple sclerosis

NeuroImage, 2020
Behavioral studies investigating fundamental cognitive abilities provide evidence that processing speed accounts for large proportions of performance variability between individuals.
Dinesh K. Sivakolundu, Kathryn L. West, Mark Zuppichini, Monroe P. Turner, Dema Abdelkarim, Yuguang Zhao, Jeffrey S. Spence, Hanzhang Lu, Darin T. Okuda, Bart Rypma   +9 more
doaj   +1 more source

Mechanisms Underlying Neurovascular Interactions: Blood-Brain Barrier and Neurovascular Coupling

, 2020
To continuously compute neural activity for perception, motor movements and cognition, the central nervous system (CNS) requires a homeostatic microenvironment that is not only enriched in nutrients to meet its high metabolic demands but also devoid of ...
Chow, Brian Wai
core