Results 131 to 140 of about 15,500 (253)

Gene Therapy for Amino Acid Decarboxylase Deficiency: Clinical and Imaging Outcomes in a French Cohort

Movement Disorders, EarlyView.
Abstract Background Intracerebral gene therapy is effective for amino acid decarboxylase (AADC) deficiency, but relationships between anatomical putaminal coverage, metabolic dynamics, and clinical recovery remain poorly understood. Objectives Assess safety, long‐term efficacy, and clinical–radiological correlations in a genetically diverse European ...
Clément Dunoyer, Gaëtan Poulen, Marie‐Céline François‐Heude, Eline Chauvet‐Piat, Bérénice Lecardonnel, Emmanuel Roze, Marie‐Ange Nguyen Morel, Domitille Gras, Adeline Quintard, Gaelle Baroux, Pierre Meyer, Philippe Coubes, Christophe Milesi, Julien Baleine, Chrystelle Sola, Vivien Szabo, Bénédicte Delye, Jana Haberlova, Mohamed Osman Eltahir Babiker, Mohammed Al Muqbil, Stéphanie Sanchez, Souad Touati, Nicolas Leboucq, Virginie Kouyoumdjian, Sylvia Sanquer, Denis Mariano‐Goulart, Thomas Roujeau, Agathe Roubertie   +27 more
wiley   +1 more source

Simultaneous In Vivo Electrophysiology, Two-Photon Imaging, and Optogenetics for Probing Neurovascular Coupling. [PDF]

Methods Protoc
Ahirwar D, Xie K, O'Herron P.
europepmc   +1 more source

Real‐World Evaluation of Bilateral Magnetic Resonance–Guided Focused Ultrasound Thalamotomy in Essential Tremor

Movement Disorders, EarlyView.
Abstract Background Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy is effective in treating essential tremor (ET) with an adequate safety profile. Objective The aim of the study was to evaluate the real‐world safety and efficacy of staged bilateral MRgFUS thalamotomy in ET and its impact on patient's quality of life (QoL) and patient‐
Dolores Vilas, Antonio Gonzalez, Manel Tardáguila, Lourdes Ispierto, Mireia Gea, José Antonio Pérez, Raquel García, Ramiro Álvarez, Jorge Muñoz   +8 more
wiley   +1 more source

Data-driven wavelet coherence approach to assess neurovascular coupling in neonatal hypoxic-ischemic encephalopathy. [PDF]

Neurophotonics
Kota S, Norasteh S, Liu H, Bhandari EJ, Liu YL, Zhang R, Chalak LF.   +6 more
europepmc   +1 more source

SPG4 Hereditary Spastic Paraplegia: From Etiology to Therapy

Movement Disorders, EarlyView.
Abstract Hereditary spastic paraplegias (HSPs) comprise a heterogeneous group of heritable neurodegenerative disorders resulting from mutations in a wide variety of genes. HSP locomotor symptoms include lower limb weakness and spasticity that arise from progressive degeneration of corticospinal axons projecting from the motor cortex to the distal ...
Emanuela Piermarini, Peter W. Baas
wiley   +1 more source

Capillary-Associated Microglia in Neurovascular Coupling: Localization, Mechanisms, and Disease Implications. [PDF]

J Neuroinflammation
Lu H, Zhang Y, Chen C, Xie H, Li Y, Qiu S.   +5 more
europepmc   +1 more source

Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications

Neuroprotection, EarlyView.
Circadian dysregulation contributes to Alzheimer's disease through sleep disruption, clock‐gene dysfunction, neuroinflammation, impaired proteostasis, and metabolic imbalance. These alterations promote cognitive decline and disease progression, while circadian biomarkers and chronotherapeutic interventions offer opportunities for precision diagnosis ...
Bivek Singh, Filippo Pigazzani, Roberto Manfredini   +2 more
wiley   +1 more source

Diurnal variation in neurovascular coupling and the impact of sleep quality: a UK Biobank study. [PDF]

Sleep
Yang S, Webb AJS.
europepmc   +1 more source

Hypercapnia dissociates neuronal and hemodynamic responses impairing neurovascular coupling and functional brain connectivity. [PDF]

Nat Commun
Gezginer I, Chen Y, Zerbi V, Chen Z, Razansky D.   +4 more
europepmc   +1 more source

Small‐Scale Magnetic Soft Robots for Medical Applications: From Laboratory to Clinical Use

SmartBot, EarlyView.
Small‐scale magnetic soft robots are emerging as promising platforms for minimally invasive diagnosis and therapy in complex in vivo environments. This review compares untethered and tethered medical magnetic robots in parallel across five translational stages, from basic performance testing to clinical evaluation.
Xingxing Ke, Shizhi Li, Tianrui Zhang, Yue Zhong, Songyang Li, Shuo Zhang, Zhiping Chai, Menghao Pu, Zisheng Zong, Haochen Yong, Xingxing Dong, Lanting Huang, Zhen Deng, Shuaizheng Yan, Yue Zhang, Zhaoju Zhu, Mingzhu Zhu, Linze Li, Ruiquan Chen, Shu Zhang, Chong Wu, Di Wu, Lei Yang, Rui Chen, Tongzhi Niu, Hongling Qin, Han Ding, Bingwei He, Siqi Wu, Zhigang Wu   +29 more
wiley   +1 more source