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Immuno-Colorimetric Neutralization Test: A Surrogate for Widely Used Plaque Reduction Neutralization Tests in Public Health Virology [PDF]

open access: yesViruses, 2023
Since their first documentation in 1952, plaque reduction neutralization tests (PRNTs) have become the choice of test for the measurement of neutralizing antibodies against a particular virus.
Sunil R. Vaidya
doaj   +2 more sources

Body Temperature Drop as a Humane Endpoint in Snake Venom-Lethality Neutralization Tests [PDF]

open access: yesToxins, 2023
Snake venom neutralization potency tests are required for quality control assessment by manufacturers and regulatory authorities. These assays require the use of large numbers of mice that manifest severe signs associated with pain and distress and long ...
Rosa De Jesus   +7 more
doaj   +2 more sources

Variation in dengue virus plaque reduction neutralization testing: Systematic review and pooled analysis [PDF]

open access: green, 2012
BackgroundThe plaque reduction neutralization test (PRNT) remains the gold standard for the detection of serologic immune responses to dengue virus (DENV).
Kaitlin Rainwater‐Lovett   +3 more
openalex   +5 more sources

Performance evaluation of four surrogate Virus Neutralization Tests (sVNTs) in comparison to the in vivo gold standard test

open access: goldFrontiers in Bioscience-Landmark, 2022
Background: Several commercial surrogate Virus Neutralization Tests (sVNTs) have been developed in the last year. Neutralizing anti-SARS-CoV-2 antibodies through interaction with Spike protein Receptor Binding Domain (S-RBD) can block the virus from ...
Massimo Pieri   +14 more
doaj   +2 more sources

Antibody Production after COVID-19 Vaccination in Patients with Inborn Errors of Immunity [PDF]

open access: yesIranian Journal of Immunology, 2023
Background: Few studies have evaluated COVID-19 vaccine efficacy in patients with inborn errors of immunity (IEI).Objective: To evaluate the levels of antibody (Ab) production and function after COVID-19 vaccination in IEI patients with phagocytic ...
Maryam Nourizadeh   +6 more
doaj   +1 more source

Evaluation of Two Serological Assays for Diagnosing Zika Virus Infection

open access: yesDiagnostics, 2021
Zika virus (ZIKV) emerged and spread rapidly in South American countries during 2015. Efforts to diagnose ZIKV infection using serological tools were challenging in dengue-endemic areas because of antigenic similarities between both viruses.
Steev Loyola   +7 more
doaj   +1 more source

SARS-CoV-2–Specific Antibodies in Domestic Cats during First COVID-19 Wave, Europe

open access: yesEmerging Infectious Diseases, 2021
We conducted a severe acute respiratory syndrome coronavirus 2 antibody seroprevalence study among >2,000 domestic cats from 4 countries during the first coronavirus disease wave in Europe.
Claudia Schulz   +10 more
doaj   +1 more source

Estimation of SARS-CoV-2 Neutralizing Activity and Protective Immunity in Different Vaccine Types Using Three Surrogate Virus Neutralization Test Assays and Two Semiquantitative Binding Assays Targeting the Receptor-Binding Domain

open access: yesMicrobiology Spectrum, 2022
Estimating neutralizing activity in vaccinees is crucial for predicting the protective effect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Beomki Lee   +22 more
doaj   +1 more source

Optimization of Flow-Cytometry Based Assay for Measuring Neutralizing Antibody Responses against Each of the Four Dengue Virus Serotypes

open access: yesVaccines, 2021
Dengue is an important public health problem worldwide, with India contributing nearly a third of global dengue disease burden. The measurement of neutralizing antibody responses is critical for understanding dengue pathophysiology, vaccine development ...
Pragati Sharma   +5 more
doaj   +1 more source

Comparison of virus neutralization activity and results of 10 different anti-SARS-CoV-2 serological tests in COVID-19 recovered plasma donors

open access: yesPractical Laboratory Medicine, 2021
Serological testing is a tool to predict protection against later infection. This potential heavily relies on antibody levels showing acceptable agreement with gold standard virus neutralization tests.
Zsófia Szabó   +12 more
doaj   +1 more source

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