Results 61 to 70 of about 358,601 (360)

Testing for Neutrality in Samples With Sequencing Errors [PDF]

Genetics, 2008
AbstractMany data sets one could use for population genetics contain artifactual sites, i.e., sequencing errors. Here, we first explore the impact of such errors on several common summary statistics, assuming that sequencing errors are mostly singletons. We thus show that in the presence of those errors, estimators of θ can be strongly biased.
openaire   +3 more sources

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Overview of Serological Techniques for Influenza Vaccine Evaluation: Past, Present and Future [PDF]

, 2014
Serological techniques commonly used to quantify influenza-specific antibodies include the Haemagglutination Inhibition (HI), Single Radial Haemolysis (SRH) and Virus Neutralization (VN) assays.
Callow, Calza, Chan, Cosma, De Jong, Farrohi, Ferrara, Fox, Frank, Fulton, Gross, Halloran, Harmon, Hierholzer, Johansson, Johansson, Kendal, Kilbourne, Montomoli, Okuno, O’Neill, Powers, Probert, Rowe, Schild, Schulman, Schulman, Scott, Sylte, Van Assen, Yewdell   +30 more
core   +3 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Multiplex evaluation of influenza neutralizing antibodies with potential applicability to in-field serological studies [PDF]

, 2014
The increased number of outbreaks of H5 and H7 LPAI and HPAI viruses in poultry has major public and animal health implications. The continuous rapid evolution of these subtypes and the emergence of new variants influence the ability to undertake ...
Cattoli, G., Cattoli, G., Molesti, E., Molesti, E., Rahman, R., Rahman, R., Temperton, N.J., Temperton, N.J., Terregino, C., Terregino, C., Wright, E., Wright, E.   +11 more
core   +6 more sources

Progress in the ITER neutral beam test facility [PDF]

Nuclear Fusion, 2019
Heating neutral beam (HNB) injectors, necessary to achieve burning conditions and to control plasma instabilities in ITER, are characterized by such demanding parameters that a neutral beam test facility (NBTF) dedicated to their development and optimization is being realized in Padua (Italy) with direct contributions from the Italian government ...
Toigo V, Dal Bello S, Bigi M, Boldrin M, Chitarin G, Grando L, Luchetta A, Marcuzzi D, Pasqualotto R, Pomaro N, Serianni G, Zaccaria P, Zanotto L, Agostinetti P, Agostini M, Antoni V, Aprile D, Barbisan M, Battistella M, Brombin M, Cavazzana R, Dalla Palma M, Dan M, Denizeau S, De Lorenzi A, Delogu R, De Muri M, Fadone M, Fellin F, Ferro A, Fiorentin A, Gaio E, Gambetta G, Gasparini F, Gnesotto F, Jain P, Maistrello A, Manduchi G, Manfrin S, Marchiori G, Marconato N, Moresco M, Ocello E, Patton T, Pavei M, Peruzzo S, Pilan N, Pimazzoni A, Piovan R, Poggi C, Recchia M, Rizzolo A, Rostagni G, Sartori E, Siragusa M, Sonato P, Sottocornola A, Spada E, Spagnolo S, Spolaore M, Taliercio C, Tinti P, Ugoletti M, Valente M, Zamengo A, Zaniol B, Zaupa M, Boilson D, Rotti C, Veltri P, Chareyre J, Decamps H, Dremel M, Graceffa J, Geli F, Schunke B, Svensson L, Urbani M, Bonicelli T, Agarici G, Garbuglia A, Masiello A, Paolucci F, Simon M, BadlyMaitre L, Bragulat E, Gomez G, Gutierrez D, Labate C, Mico G, Moreno J F, Pilard V, Kouzmenko G, Rousseau A, Kashiwagi M, Tobari H, Watanabe K, Maejima T, Kojima A, Umeda N, Sasaki S, Chakraborty A, Baruah U, Patel H, Singh N P, Patel A, Dhola H, Raval B, Gupta V, Fantz U, Heinemann B, Kraus W, Cavenago M, Hanke S, Ochoa S, Blatchford P, Chuilon B, Xue Y, Croct G, Gorini G, Muraro A, Rebai M, Tardocchi M, D'Arienzo M, Sandri S, Tonti A, Panin F   +126 more
openaire   +2 more sources

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Studies of bacteriophages induced from Streptococcus cremoris strain R1 : is R1 a double Lysogen? : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University, New Zealand [PDF]

, 1979
Early studies on Streptococcus cremoris strain R₁ suggested that it was polylysogenic. Later, it was reported that its induced lysates contained bacteriophages (phages) of two types which were believed to differ in their morphology, buoyant densities ...
Phua, Sin Hen
core  

On tests of local realism by CP-violation parameters of K^0 mesons [PDF]

Eur.Phys.J.C42:25-28,2005, 2005
Recently various papers have proposed to test local realism (LR) by considering electroweak CP-violation parameters values in neutral pseudoscalar meson systems. Considering the large interest for a conclusive test of LR and the experimental accessibility to these tests, in this paper we critically consider these results showing how they, albeit very ...
arxiv   +1 more source